PROBABILISTIC GENERALIZATION OF PENNA AGEING MODEL AND THE OLDEST OLD

1999 ◽  
Vol 10 (07) ◽  
pp. 1363-1365 ◽  
Author(s):  
D. STAUFFER
Keyword(s):  
Oldest Old ◽  
Demographic Data ◽  
Absolute Maximum ◽  
Maximum Life Span ◽  
Monte Carlo Data ◽  
Biological Ageing ◽  
Probabilistic Generalization ◽  
Ageing Model ◽  
Penna Model ◽  
Rich Countries

Using a 1995 method of Thoms et al., the traditional Penna model of biological ageing is modified such that there is no more absolute maximum life span; instead, our Monte Carlo data are similar to real demographic data collected by Thatcher et al., for rich countries.

Strategies of Reproduction and Longevity

1998 ◽  
Vol 09 (06) ◽  
pp. 787-791 ◽  
Author(s):  
M. Argollo de Menezes ◽  
A. Racco ◽  
T. J. P. Penna
Keyword(s):  
Computer Simulations ◽  
Mutation Accumulation ◽  
Biological Ageing ◽  
Penna Model

In this work we try to verify whether the increased lifespan of trees and some lobsters, like Homarus, whose fertility increases with advancing age, can be explained by the mutation accumulation theory of biological ageing. Computer simulations of the Penna model seems to support this hypothesis, showing that it is a robust strategy of reproduction.

scholarly journals Intravenous Thrombolytic Treatment in the Oldest Old

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Juan García-Caldentey ◽  
María Alonso de Leciñana ◽  
Patricia Simal ◽  
Blanca Fuentes ◽  
Gemma Reig ◽  
...  
Keyword(s):  
Intracranial Haemorrhage ◽  
Primary Outcome ◽  
Oldest Old ◽  
Demographic Data ◽  
Intravenous Thrombolysis ◽  
Modified Rankin Scale ◽  
Thrombolytic Treatment ◽  
Old Patients ◽  
Nihss Score ◽  
Tissue Plasminogen

Background and Purpose.Intravenous thrombolysis using tissue plasminogen activator is safe and probably effective in patients >80 years old. Nevertheless, its safety has not been specifically addressed for the oldest old patients (≥85 years old, OO). We assessed the safety and effectiveness of thrombolysis in this group of age.Methods.A prospective registry of patients treated with intravenous thrombolysis. Patients were divided in two groups (<85 years and the OO). Demographic data, stroke aetiology and baseline National Institute Health Stroke Scale (NIHSS) score were recorded. The primary outcome measures were the percentage of symptomatic intracranial haemorrhage (SICH) and functional outcome at 3 months (modified Rankin Scale, mRS).Results.A total of 1,505 patients were registered. 106 patients were OO [median 88, range 85–101]. Female sex, hypertension, elevated blood pressure at admission, cardioembolic strokes and higher basal NIHSS score were more frequent in the OO. SICH transformation rates were similar (3.1% versus 3.7%,P=1.00). The probability of independence at 3 months (mRS 0–2) was lower in the OO (40.2% versus 58.7%,P=0.001) but not after adjustment for confounding factors (adjusted OR, 0.82; 95% CI, 0.50 to 1.37;P=0.455). Three-month mortality was higher in the OO (28.0% versus 11.5%,P<0.001).Conclusion.Intravenous thrombolysis for stroke in OO patients did not increase the risk of SICH although mortality was higher in this group.

Biological ageing with birth rate controlled by mutations in the Penna model

2000 ◽  
Vol 119 (2) ◽  
pp. 139-144 ◽  
Author(s):  
M. Magdoń-Maksymowicz ◽  
A. Z. Maksymowicz ◽  
K. Kułakowski
Keyword(s):  
Birth Rate ◽  
Biological Ageing ◽  
Penna Model ◽  
Rate Controlled

VIRGINIA OPOSSUMS, MINIMUM REPRODUCTION AGE AND PREDATORS IN THE PENNA AGING MODEL

1999 ◽  
Vol 10 (04) ◽  
pp. 717-721 ◽  
Author(s):  
A. K. ALTEVOLMER
Keyword(s):  
Demographic Data ◽  
Stable State ◽  
Biological Aging ◽  
Aging Model ◽  
Penna Model

Age-specific predators are introduced into the Penna model of biological aging. It is shown that populations with a variable minimum reproduction age find a stable state with an earlier onset of reproduction, if older ages are eaten by the predators. This behavior agrees with the demographic data of the Virgina opossum.

scholarly journals DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ruth A. Sibbett ◽  
Drew M. Altschul ◽  
Riccardo E. Marioni ◽  
Ian J. Deary ◽  
John M. Starr ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Cohort ◽  
Oldest Old ◽  
Biological Ageing ◽  
Lothian Birth Cohort

AGE-OF-PARENT DEPENDENT MUTATION RATE AND WEAK CHILDREN IN THE PENNA MODEL IN BIOLOGICAL AGEING

1996 ◽  
Vol 07 (05) ◽  
pp. 731-737 ◽  
Author(s):  
K. NIKOLAJ BERNTSEN
Keyword(s):  
Mutation Rate ◽  
High Mortality ◽  
Biological Ageing ◽  
Age Dependent ◽  
Penna Model

We investigate the effect of an age-dependent mutation rate in the Penna model of ageing and then we observe that the high mortality for human babies can be reproduced by the model if one assumes babies to be weaker than adults.

scholarly journals Telomere Length in Cystic Fibrosis Patients – Are Patients with CF Ageing Too Quickly?

2021 ◽  
pp. 90
Author(s):  
Keyword(s):  
Cystic Fibrosis ◽  
Telomere Length ◽  
Peripheral Blood ◽  
Demographic Data ◽  
Repetitive Sequences ◽  
Annual Review ◽  
Healthy Population ◽  
Healthy Individuals ◽  
Blood Samples ◽  
Biological Ageing

Life expectancy for patients living with Cystic Fibrosis (CF) is increasing year on year and there is growing interest in the ageing process in CF. Telomeres are repetitive sequences of DNA that cap the ends of eukaryotic chromosomes and shorten with ongoing cell division, thus providing a marker of replicative history and biological ageing. We aimed to investigate whether telomere length as a function of age differs between patients with CF and healthy individuals and whether telomere length is associated with severity of the patient’s CF condition. Peripheral blood samples and demographic data were collected from 47 consenting patients (age 1 to 57 years) with CF attending their routine annual review appointment at the All Wales Adult CF Centre and Noah’s Ark Children’s’ Hospital in Cardiff, UK. Telomere length profiles were assessed from peripheral blood samples, using the high resolution single telomere length analysis technique (STELA) and compared to healthy control telomere length data. Patients with CF had significantly shorter telomere lengths than healthy individuals, when adjusting for age (p<0.001). Telomere length is decreasing 70% more quickly in the CF cohort than healthy controls. Telomere length does not appear to correlate with markers of disease severity. Telomere lengths are significantly shorter in individuals with CF than in the age-adjusted healthy population. This is suggestive of premature biological ageing of peripheral blood leukocytes in CF patients.

Sign in / Sign up

Export Citation Format

Share Document