DISTRIBUTIONS OF LOCAL MANDELBROT-HURST EXPONENTS: MOTOR ACTIVITY IN FETAL RATS OF COCAINIZED MOTHERS AND MANIC-DEPRESSIVE PATIENTS

Fractals ◽  
1995 ◽  
Vol 03 (04) ◽  
pp. 893-904 ◽  
Author(s):  
KAREN A. SELZ ◽  
ARNOLD J. MANDELL ◽  
CARL M. ANDERSON ◽  
WILLIAM P. SMOTHERMAN ◽  
MARTIN H. TEICHER
Keyword(s):  
Time Series ◽  
Motor Activity ◽  
Motor Behavior ◽  
Pregnant Rats ◽  
Behavioral Systems ◽  
Statistical Indices ◽  
Manic Depressive ◽  
The One ◽  
Depressive Patients ◽  
Hurst Exponents

Intermittency, in which the normalized weight of large fluctuations grows for increasingly longer statistical samples, is seen as irregular bursting activity in time and is characteristic of the behavior of many brain and behavioral systems. This pattern has been related to the brain-stabilizing interplay of the general mechanisms of silence-evoked sensitization and activity-evoked desensitization, which can be found at most levels of neurobiological function and which vary more smoothly and at much longer times than the phasic observables. We use both the global Mandelbrot-Hurst exponent and the distribution of local Mandelbrot-Hurst exponents, in combination with dynamical entropies, to quantitate the property of nonuniform persistence which we treat as both deterministically expansive and statistically diffusive. For example, varying the parameter of the one-dimensional, Manneville-Pomeau intermittency map generated time series which demonstrated systematic changes in these statistical indices of persistence. Relatively small doses of cocaine administered to pregnant rats increased statistical indices of expansiveness and persistence in fetal motor behavior. These techniques also model and characterize a breakdown of statistical scaling in 72-hour time series of the amount of motor activity in some hospitalized manic-depressive patients.

Decreased serotonin transporter binding in unaffected relatives of manic depressive patients

1999 ◽  
Vol 46 (12) ◽  
pp. 1703-1706 ◽  
Author(s):  
Marion Leboyer ◽  
Philippe Quintin ◽  
Philippe Manivet ◽  
Odile Varoquaux ◽  
Jean-François Allilaire ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Manic Depressive ◽  
Depressive Patients

Eysenck Personality Inventory as a Mood Test with Manic-Depressive Patients

1970 ◽  
Vol 27 (3) ◽  
pp. 947-952 ◽  
Author(s):  
S. R. Platman ◽  
R. Plutchik
Keyword(s):  
Normal State ◽  
Depressive Mood ◽  
Personality Inventory ◽  
Eysenck Personality Inventory ◽  
Manic State ◽  
Manic Depressive ◽  
Depressive Patients

The Eysenck Personality Inventory was used as a mood indicator instead of as a trait test with a group of manic-depressive patients associated with a research ward. Some patients completed the EPI while in a normal state, some while in a depressed or manic state, and some in two or more clinically defined states. Results showed that depression was associated with a significant decrease in extraversion and a significant increase in neuroticism. The manic state however, was not clearly differentiated from the normal one. It appears that the inventory may be a useful indicator of depressive mood.

Prediction of clinical course of bipolar manic depressive illness treated with lithium

1980 ◽  
Vol 10 (2) ◽  
pp. 329-334 ◽  
Author(s):  
B. B. Johnston ◽  
G. J. Naylor ◽  
E. G. Dick ◽  
S. E. Hopwood ◽  
D. A. T. Dick
Keyword(s):  
Atpase Activity ◽  
Clinical Response ◽  
Poor Prognosis ◽  
Clinical Course ◽  
Lithium Concentration ◽  
Good Prognosis ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Depressive Patients

SYNOPSISA group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na–K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na–K ATPase activity.

300. Activated lymphocytes in manic-depressive patients

2000 ◽  
Vol 47 (8) ◽  
pp. S91
Author(s):  
M.R. Issidorides ◽  
S. Havaki ◽  
M. Chrysanthou-Piterou ◽  
M. Michalopoulou ◽  
V. Alevizos ◽  
...  
Keyword(s):  
Activated Lymphocytes ◽  
Manic Depressive ◽  
Depressive Patients

PLASMA PROLACTIN AND PROGESTERONE RESPONSES TO MATING ARE ALTERED IN AGED RATS

1981 ◽  
Vol 90 (2) ◽  
pp. 179-191 ◽  
Author(s):  
S. HENDRICKS ◽  
C. A. BLAKE
Keyword(s):  
Plasma Concentrations ◽  
External Jugular Vein ◽  
Female Rats ◽  
Plasma Prolactin ◽  
Aged Rats ◽  
Pregnant Rats ◽  
Pregnant Rat ◽  
Plasma Progesterone ◽  
The One ◽  
The Right

The effects of varying amounts of copulatory stimulation on patterns of plasma concentrations of prolactin and progesterone were evaluated in 3- and 12-month-old female rats. The 12-month-old group included rats which still exhibited oestrous cycles and rats in persistent vaginal oestrus (PVO). The extent of copulatory stimulation was defined by the number of intromissions received during mating: ≤5,15 or > 50. Blood samples were drawn over the 8 days after mating through a cannula inserted into the right external jugular vein. Plasma from the samples was assayed for prolactin and progesterone. In aged but still cyclic rats, pregnancy rates were positively correlated with the number of intromissions received during mating. Only one rat in PVO became pregnant. All animals which became pregnant and rats in PVO which, after mating, exhibited a disruption of the pattern of PVO, showed the nocturnal surge of plasma prolactin characteristic of pregnant and pseudopregnant rats. While these surges persisted until day 8 after mating in pregnant animals, they were absent by this time in the rats in PVO. Prolactin surges were present in some but not all of the aged rats which did not become pregnant. Progesterone concentrations were raised in all pregnant animals except the one pregnant rat in PVO and, while not related to the number of intromissions, concentrations were higher 8 days after mating in young compared with those in aged pregnant rats. Plasma progesterone was low in rats in PVO regardless of disruption of the pattern of PVO. We have concluded that the failure of limited copulatory stimulation to induce pregnancy in older rats results, at least in part, from its failure to initiate nocturnal prolactin surges. Nevertheless, our data suggest that matings which are not experimentally limited should provide ample stimulation to establish such surges. Although reduced plasma concentrations of prolactin and progesterone at pro-oestrus and reduced plasma progesterone through part of gestation may contribute to decreasing fertility in aged rats, other unidentified factors appear to be involved in mediating the capacity of extensive copulatory stimulation to induce pregnancy in these animals.

ENDOCRINE EFFECTS OF LITHIUM:

1978 ◽  
Vol 88 (3) ◽  
pp. 528-534 ◽  
Author(s):  
C. Christiansen ◽  
P. C. Baastrup ◽  
P. Lindgreen ◽  
I. Transbøl
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Serum Calcium ◽  
Lithium Treatment ◽  
Serum Magnesium ◽  
Endocrine Effects ◽  
Manic Depressive ◽  
Depressive Patients ◽  
Immunoreactive Parathyroid Hormone

ABSTRACT Ninety-six manic-depressive patients were studied during long-term lithium treatment. Highly significant elevations were observed respecting the levels of serum immunoreactive parathyroid hormone (P < 0.001) as well as the protein-corrected levels of serum calcium (P < 0.001) and serum magnesium (P <0.001), thus indicating a state of 'primary' hyperparathyroidism. The patients as a group had normophosphataemia and normophosphatasia supporting the impression of a rather mild state of biochemical hyperparathyroidism.

Sign in / Sign up

Export Citation Format

Share Document