Prediction of clinical course of bipolar manic depressive illness treated with lithium

1980 ◽  
Vol 10 (2) ◽  
pp. 329-334 ◽  
Author(s):  
B. B. Johnston ◽  
G. J. Naylor ◽  
E. G. Dick ◽  
S. E. Hopwood ◽  
D. A. T. Dick
Keyword(s):  
Atpase Activity ◽  
Clinical Response ◽  
Poor Prognosis ◽  
Clinical Course ◽  
Lithium Concentration ◽  
Good Prognosis ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Depressive Patients

SYNOPSISA group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na–K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na–K ATPase activity.

Did Manic–Depressive Patients Who Committed Suicide Receive Prophylactic or Continuation Treatment at the Time?

1988 ◽  
Vol 153 (3) ◽  
pp. 324-327 ◽  
Author(s):  
M. Schou ◽  
A. Weeke
Keyword(s):  
Suicide Prevention ◽  
Prophylactic Treatment ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Psychiatric Admission ◽  
Ongoing Treatment ◽  
Manic Depressive ◽  
Continuation Treatment ◽  
Adequate Dosage ◽  
Depressive Patients

Ninety-two Danish manic–depressive patients with a first psychiatric admission between 1969 and 1983, who committed suicide before 1 July 1986, were considered. Information on any prophylactic or continuation treatment at the time of the suicide was obtained. In 64 of the patients, every precaution seems to have been taken: 28 patients committed suicide during ongoing treatment; 10 while not receiving prophylactic treatment (not indicated); 7 while not in prophylactic treatment because the patients refused or did not tolerate such; and 19 while in prophylactic treatment with antidepressants (10), or lithium (6), or both (3), in usually adequate dosage. In 28 of the patients, suicide might have been obviated. Guidelines for improvement of suicide prevention in manic–depressive illness are presented.

Disturbance of Water and Sodium in a Manic-Depressive Illness

1986 ◽  
Vol 149 (3) ◽  
pp. 337-345 ◽  
Author(s):  
J. L. Crammer
Keyword(s):  
Mental Illness ◽  
Body Weight ◽  
Body Weight Gain ◽  
Depressive Illness ◽  
Bladder Function ◽  
Manic Depressive Illness ◽  
Aldosterone Secretion ◽  
Manic Depressive ◽  
Depressive Patients ◽  
Frequent Observation

Specific questioning and frequent observation of a 69 year-old woman with cyclic bipolar manic-depressive illness showed that she had disturbances of thirst, appetite, bowel and bladder function and dramatic changes in body weight, in association with different phases of her mental illness. Examination of one manic phase under constant diet and inpatient control showed cardiovascular changes, sodium retention, body weight gain, with raised aldosterone secretion but steady vasopressin. There appears to be a sub-group of manic-depressive patients with evidence of disturbed hypothalamic functions as part of their mental illness, as shown particularly by changes in water and electrolyte metabolism.

scholarly journals Revisiting Shimoda's “Shuuchaku-Kishitsu” (Statothymia): A Japanese View of Manic-Depressive Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
Hitoshi Tsuda
Keyword(s):  
Clinical Significance ◽  
Outer Space ◽  
Academic Research ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
The Past ◽  
Manic Depressive ◽  
Continental Origin ◽  
Personality Features ◽  
Depressive Patients

Although the empiric paradigm is now dominant in academic research, in Japan quite a few psychiatric clinicians still take phenomenological-anthropological approaches into consideration, especially when they address manic-depressive illness with typical endogenous features. This is because Shimoda's concept of “shuuchaku-kishitsu” (statothymia) has been widely accepted, together with other phenomenological views of continental origin. In the present paper the author first delineates Shimoda's concept which is based on observations of patients' personality features and the characteristics of their emotionality. He then attempts to refine this concept in spatiotemporal terms, presenting the view that in patients the past self tends to adhere to the present self (the term “shuuchaku” means “adhering to” or “preoccupied with”). He also considers that patients tend to incorporate “soto” (outer space) into “uchi” (inner space), where they believe that symbiotic relations are preserved. Finally, he argues the clinical significance of the presented views in the cultural milieu in which Japanese psychiatric practices are situated.

Follow-up of 53 Bipolar Manic-Depressive Patients

1974 ◽  
Vol 124 (579) ◽  
pp. 134-139 ◽  
Author(s):  
Gabrielle A. Carlson ◽  
Joel Kotin ◽  
Yolande B. Davenport ◽  
Marvin Adland
Keyword(s):  
Clinical Importance ◽  
Lithium Carbonate ◽  
Depressive Illness ◽  
National Institutes Of Health ◽  
Manic Depressive Illness ◽  
Level Of Functioning ◽  
Manic Depressive ◽  
Depressive Patients

Despite the monumental follow-up studies of patients with manic-depressive illness by Lundquist (1945), Rennie (1942), Hastings (1958), and more recently, Shobe (1971), the development of the concept of unipolar and bipolar forms of affective disorders with clinical (Brodie and Leff, 1971), genetic (Dunner et al., 1970; Winokur et al., 1969), and biologic differences (Buchsbaum et al., 1971; Cohn et al., 1970), has necessitated a revaluation of the question of outcome in this psychiatric illness. The availability of lithium carbonate for both acute and prophylactic treatment of mania (Schou, 1968; Coppen et al., 1971), and possibly depression (Goodwin et al., 1972), has also increased the clinical importance of the unipolar-bipolar distinction. The purpose of this study is to provide further information regarding the course of bipolar manic-depressive illness by reporting the level of functioning, recurrence of episodes, and quality of life at follow-up assessed in a group of patients formerly hospitalized for mania at the National Institutes of Health.

The effects of administering lithium carbonate on the balance of Na, K and water in manic-depressive patients

1976 ◽  
Vol 6 (3) ◽  
pp. 381-392 ◽  
Author(s):  
Brij M. Saran ◽  
Gerald F. M. Russell
Keyword(s):  
Early Stage ◽  
Isotonic Saline ◽  
Lithium Carbonate ◽  
Depressive Illness ◽  
Significant Alteration ◽  
Manic Depressive Illness ◽  
Short Term ◽  
Manic Depressive ◽  
Before And After ◽  
Depressive Patients

SynopsisEleven patients in remission from manic-depressive illness were studied by means of metabolic balances before and after the administration of lithium carbonate. Lithium caused a sharp diuresis of isotonic saline and a smaller excretion of potassium over the course of two days. During the subsequent two days there occurred a compensatory retention of Na, K and water. These short-term changes were not associated with any significant alteration in the patients' mood. There was no significant and systematic retention of Na, K or water over the 14 days of Li administration. The recovery of Li was measured simultaneously. During the first week only a proportion of the administered Li was recovered in the urine and faeces, suggesting that a gradual distribution of Li throughout its body space was occurring. After the first week, nearly all the administered Li was recovered, indicating an equilibrium with an even distribution of the ion throughout its body space. This equilibrium was more complete at this early stage in those patients who had been given a smaller dose of lithium carbonate.

LITHIUM RATIO AND CLINICAL RESPONSE IN MANIC-DEPRESSIVE ILLNESS

The Lancet ◽  
1977 ◽  
Vol 309 (8001) ◽  
pp. 41-42 ◽  
Author(s):  
J. Mendlewicz ◽  
P. Verbanck ◽  
D. Brunswick ◽  
A. Frazer ◽  
J. Mendels ◽  
...  
Keyword(s):  
Clinical Response ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive

Platelet Monoamine Oxidase in Schizophrenia and Manic-Depressive Illness

1976 ◽  
Vol 129 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Robert H. Belmaker ◽  
Kirsten Ebbesen ◽  
Richard Ebstein ◽  
Ranan Rimon
Keyword(s):  
Monoamine Oxidase ◽  
Health Centre ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Platelet Mao ◽  
Schizophrenic Patients ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Depressive Patients

SummaryMonoamine oxidase (MAO) is an important enzyme in the catabolism of brain biogenic amines. Platelet MAO has been reported to be moderately reduced in manic-depressive patients and markedly reduced in schizophrenic patients. This enzyme's activity has been shown to be under a large degree of genetic control and has been proposed as a ‘genetic marker’ in schizophrenia. A transcultural replication of the finding of low platelet MAO in schizophrenia and manic-depressive illness was carried out at the Jerusalem Mental Health Centre. Manic-depressive patients were found to have higher platelet MAO activity than schizophrenic patients, as reported previously, but control individuals were as low as the schizophrenic patients. It is unlikely that platelet MAO activity is a transculturally-valid marker for schizophrenia.

Lithium treatment in affective disorders: The significance of strongly elevated erythrocyte choline levels

1995 ◽  
Vol 7 (2) ◽  
pp. 67-69
Author(s):  
F. Flentge ◽  
C.J. Slooff
Keyword(s):  
Treatment Response ◽  
Erythrocyte Membrane ◽  
Affective Disorders ◽  
Lithium Treatment ◽  
Depressive Illness ◽  
Lithium Salts ◽  
Clinical Effects ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Depressive Patients

In manic-depressive patients treated with lithium salts the transport of choline over the erythrocyte membrane is strongly inhibited, resulting in dramatically increased erythrocyte choline levels (for review see ref. 1). Whether or not there is a relationship between this effect and treatment response is not clear. Data on this issue are scarce possibly because the measurement of treatment response in lithium prophylaxis is very difficult and time consuming. Also the effect on erythrocyte choline is specific for lithium and not for manic-depressive illness. We will address here the question of a possible relation between erythrocyte choline and clinical effects of lithium.

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