CYTOKERATIN PROFILES OF CANINE ANAL SAC AND HEPATOID GLAND NEOPLASMS

2018 ◽  
Vol 44 (03) ◽  
pp. 119-123
Author(s):  
Adam W. Stern ◽  
Amanda J. Young ◽  
Jason B. Pieper
Keyword(s):  
Apocrine Gland ◽  
Cytokeratin 7 ◽  
Coordinate Expression ◽  
Anal Sac ◽  
Cytokeratin 14

Ten adenocarcinomas of the apocrine gland of the anal sac and 11 hepatoid gland neoplasms were studied to determine the coordinate expression of cytokeratin 7 (CK7) and cytokeratin 14 (CK14) using commercially available antibodies. Hepatoid gland neoplasms included hepatoid gland adenomas, carcinomas and a single epithelioma. All 10 (100%) adenocarcinomas of the apocrine gland of the anal sac had CK7[Formula: see text]/CK14[Formula: see text] immunophenotype, whereas all 11 (100%) of hepatoid neoplasms expressed CK7[Formula: see text]/CK14[Formula: see text] immunophenotype. Hepatoid gland adenomas, carcinomas, and epithelioma could not be differentiated based on the cytokeratin immunophenotype. Hepatoid gland neoplasms could be differentiated from adenocarcinomas of the apocrine gland of the anal sac by differences in the CK7/CK14 immunophenotypes with a [Formula: see text]-[Formula: see text]. The results of this study provide further support for the use of coordinate expression of CK7/CK14 to differentiate apocrine gland adenocarcinomas of the anal sac (CK7[Formula: see text]/CK14[Formula: see text]) from hepatoid gland neoplasms (CK7[Formula: see text]/CK14[Formula: see text]).

scholarly journals Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1649
Author(s):  
Emanuela Maria Morello ◽  
Marzia Cino ◽  
Davide Giacobino ◽  
Arturo Nicoletti ◽  
Selina Iussich ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Vascular Invasion ◽  
Apocrine Gland ◽  
Regional Lymph Nodes ◽  
Disease Free Interval ◽  
Lymph Nodes Metastasis ◽  
Free Interval ◽  
Histologic Pattern ◽  
Anal Sac ◽  
Disease Free

Apocrine gland anal sac adenocarcinoma (AGASACA) is locally aggressive and highly metastatic to regional lymph nodes. The aim of this study was to evaluate the prognostic significance of Ki67 in surgically excised AGASACA. Prognostic impact of size, regional lymph nodes metastasis, hypercalcemia, histologic pattern, mitotic count, necrosis, inflammatory and lympho-vascular invasion, anisokaryosis and anisocytosis was also evaluated. Thirty-five dogs were included, twenty-four of which also had metastatic lymph nodes. When the entire population was evaluated, only metastatic disease spread to regional lymph nodes, and necrosis and inflammatory infiltration were correlated to prognosis. When only dogs with metastatic disease were evaluated, size, solid histologic pattern, presence of lymphatic and vascular invasion showed influence on prognosis. Ki67 index was not associated with survival time and disease free interval in any case. The results of this study showed that lymph nodes metastasis at diagnosis reduced disease free interval. Moreover, tumor size greater than 5.25 cm, presence of lymphatic and vascular invasion and a solid histologic pattern were associated with a shorter survival time in dogs with metastasis to regional lymph nodes. Ki67 expression was not significantly associated with prognosis, therefore it could not be considered as a prognostic factor in this tumor type, while the role of hypercalcemia remained unclear.

Apocrine gland anal sac adenocarcinoma in cats: 30 cases (1994–2015)

2019 ◽  
Vol 254 (6) ◽  
pp. 716-722 ◽  
Author(s):  
Pierre M. Amsellem ◽  
Ryan P. Cavanaugh ◽  
Po-Yen Chou ◽  
Nicholas J. Bacon ◽  
Sandra P. Schallberger ◽  
...  
Keyword(s):  
Apocrine Gland ◽  
Anal Sac

Adherence to follow‐up recommendations for dogs with apocrine gland anal sac adenocarcinoma: A multicentre retrospective study

2020 ◽  
Vol 18 (4) ◽  
pp. 683-688
Author(s):  
Aidan R. Chambers ◽  
Owen T. Skinner ◽  
Megan A. Mickelson ◽  
Ariel N. Schlag ◽  
James Ryan Butler ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Apocrine Gland ◽  
Anal Sac ◽  
Multicentre Retrospective Study

Comparison of methods to determine primary tumour size in canine apocrine gland anal sac adenocarcinoma

2020 ◽  
Vol 61 (3) ◽  
pp. 185-189 ◽  
Author(s):  
A. N. Schlag ◽  
T. Johnson ◽  
A. Vinayak ◽  
A. Kuvaldina ◽  
O. T. Skinner ◽  
...  
Keyword(s):  
Tumour Size ◽  
Primary Tumour ◽  
Apocrine Gland ◽  
Comparison Of Methods ◽  
Anal Sac

Unilateral anal sacculectomy for anal sac apocrine gland adenocarcinoma with urethral involvement

2021 ◽  
Vol 12 (8) ◽  
pp. 380-385
Author(s):  
Hayleigh Robbins
Keyword(s):  
Urinary Catheter ◽  
Full Recovery ◽  
Nursing Interventions ◽  
Anal Gland ◽  
Apocrine Gland ◽  
Time Of Surgery ◽  
History Of ◽  
Anal Sac ◽  
Veterinary Hospital ◽  
Catheter Care

The patient presented to a veterinary hospital with a month-long history of ‘scooting’ and a right-sided anal gland mass. A diagnosis of a stage 2 anal sac apocrine gland adenocarcinoma was confirmed, and the patient underwent a right-sided anal sacculectomy. There was involvement of the urethra and adherence to the rectum and a subsequent urethral incision was necessary, which was surgically repaired at the time of surgery. The patient was hospitalised for several weeks postoperatively for urinary catheter care and further nursing interventions. The patient was discharged from hospital 3 weeks after surgery once the urethra had healed sufficiently enough to enable normal micturition and subsequently made a full recovery.

Expression of E-cadherin in Canine Anal Sac Apocrine Gland Adenocarcinoma and its Association with Survival

2005 ◽  
Vol 3 (1) ◽  
pp. 53-54
Author(s):  
G. A. Polton ◽  
V. Adams ◽  
L. M. Green ◽  
M. J. Brearley ◽  
T. J. Scase
Keyword(s):  
Apocrine Gland ◽  
Anal Sac ◽  
E Cadherin

scholarly journals Apocrine Gland Anal Sac Adenocarcinoma in Dogs: 22 Cases (2015-2020)

2021 ◽  
Author(s):  
A.K. Sahoo ◽  
I. Nath ◽  
S.B. Senapati ◽  
S.K. Panda ◽  
M.R. Das ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Regional Lymph Node ◽  
Clinical Signs ◽  
Clinical Staging ◽  
Apocrine Gland ◽  
Survival Times ◽  
Regional Lymph Nodes ◽  
Iliac Lymph Node ◽  
Anal Sac

Background: Apocrine gland anal sac adenocarcinoma (AGASACA) is a highly malignant disease mostly invading regional lymph nodes at the time of disease diagnosis.Methods: Twenty- two cases of Apocrine gland anal sac adenocarcinoma (AGASACA) were treated during five years. Contrast radiography with Iohexol and Lipidol were carried out to detect primary anal sac mass and regional lymph node through indirect lymphography technique. For clinical staging, ultrasonography, fine-needle aspiration cytology, histopathology of both primary tumor mass and regional lymph node were performed. Closed anal Sacculectomy was performed as curative therapy for anal sac adenocarcinoma.Result: The median age and weight of dogs at presentation were 8.4 years and 20.9 kg, respectively. Diagnostic radiology, histopathology and biochemical assay confirm twenty-two cases of anal sac adenocarcinoma and medial iliac lymph node to be sentinel lymph node. Carcinoma was of unilateral occurrence in all the dogs. Four (18%) dogs had hypercalcemia and twelve (54%) had metastases to the regional lymph nodes with clinical signs of tenesmus or constipation, polyuria -polydipsia and anorexia. Apocrine gland Adenocarcinoma of anal sac was found to initially metastasize to the medial iliac lymph node. Survival times of dogs treated with the surgical procedure only (8 out of 22 dogs) were appreciably longer than the dogs with therapeutic only. Animals with metastasis to regional lymph nodes or lymphadenopathy had poor prognosis.

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