ADVANCED NANOHYBRID FORMULATION OF THE SPARINGLY SOLUBLE DRUG SULINDAC FOR CONTROLLED RELEASE STUDIES

We offered an advanced nanohybrid formulation system of Sulindac (SUL) based on layered double hydroxide (LDH) nanoparticles. The formulated materials were characterized by X-rays, Infrared and SEM techniques to confirm the nanohybrid structure. The drug incorporation ratio was determined to be 45%. The drug solubility was improved after the LDH nanohybrid formation. The anion-exchange mechanism of LDH supported the dissolution process for the intercalated SUL.

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Characterization, physiochemical, controlled release studies of zinc–aluminium layered double hydroxide and zinc layered hydroxide intercalated with salicylic acid

Bulletin of Materials Science ◽

10.1007/s12034-021-02452-z ◽

2021 ◽

Vol 44 (2) ◽

Author(s):

Nurain Adam ◽

Sheikh Ahmad Izaddin Sheikh Mohd Ghazali ◽

Nur Nadia Dzulkifli ◽

Cik Rohaida Che Hak

Keyword(s):

Salicylic Acid ◽

Controlled Release ◽

Layered Double Hydroxide ◽

Release Studies ◽

Zinc Layered Hydroxide ◽

Double Hydroxide

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Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

International Journal of Nanomedicine ◽

10.2147/ijn.s42718 ◽

2013 ◽

pp. 1975 ◽

Cited By ~ 27

Author(s):

Farahnaz Barahuie ◽

Mohd Zobir Hussein ◽

Samer Hussein-Al-Ali ◽

Palanisamy Arulselvan ◽

Sharida Fakurazi ◽

...

Keyword(s):

Controlled Release ◽

Layered Double Hydroxide ◽

Protocatechuic Acid ◽

Release Studies ◽

Double Hydroxide

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Bionanocomposites based on alginate and chitosan/layered double hydroxide with ciprofloxacin drug: Investigation of structure and controlled release properties

Polymer Composites ◽

10.1002/pc.23089 ◽

2014 ◽

Vol 36 (10) ◽

pp. 1819-1825 ◽

Cited By ~ 18

Author(s):

Zolfaghar Rezvani ◽

Malihe Shahbaei

Keyword(s):

Controlled Release ◽

Layered Double Hydroxide ◽

Drug Investigation ◽

Double Hydroxide

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Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite

International Journal of Nanomedicine ◽

10.2147/ijn.s30461 ◽

2012 ◽

pp. 2129 ◽

Cited By ~ 26

Author(s):

Samer Hussein Al Ali ◽

Muhammad Nazrul-Hakim ◽

Mothanna Al-Qubaisi ◽

Mohd Zobir Hussein ◽

Zulkarnain Zainal ◽

...

Keyword(s):

Controlled Release ◽

Angiotensin Converting Enzyme ◽

Enzyme Inhibition ◽

Layered Double Hydroxide ◽

Antihypertensive Drug ◽

Angiotensin Converting Enzyme Inhibition ◽

Converting Enzyme ◽

Perindopril Erbumine ◽

Converting Enzyme Inhibition ◽

Double Hydroxide

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Hierarchical coated metal hydroxide nanoconstructs as potential controlled release carriers of photosensitizer for skin melanoma

RSC Advances ◽

10.1039/c4ra16957c ◽

2015 ◽

Vol 5 (53) ◽

pp. 42666-42680 ◽

Cited By ~ 24

Author(s):

Ranjith Kumar Kankala ◽

Yaswanth Kuthati ◽

Chen-Lun Liu ◽

Chia-Hung Lee

Keyword(s):

Controlled Release ◽

Layered Double Hydroxide ◽

Metal Hydroxide ◽

Skin Melanoma ◽

Anionic Clay ◽

Coated Metal ◽

Clay Matrix ◽

Double Hydroxide

Inorganic nanostructured ensembles containing an anionic clay matrix with layered double hydroxide (LDH) were designed in nanooncology for photosensitizer delivery.

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