scholarly journals Positron emission particle tracking: A powerful technique for flow studies

2018 ◽  
Vol 48 ◽  
pp. 1860113 ◽  
Author(s):  
A. Buffler ◽  
K. Cole ◽  
T.W. Leadbeater ◽  
M.R. van Heerden
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Gamma Rays ◽  
Particle Tracking ◽  
Tracer Particle ◽  
Emission Tomography ◽  
Scanner Data ◽  
Nuclear Technique ◽  
Positron Emission

Positron emission particle tracking (PEPT) has developed into a flexible applied nuclear technique for measuring the trajectory of a single tracer particle moving in a system of granular or liquid flow or attached to a moving rigid body. The tracer particle is labelled with a radionuclide (such as [Formula: see text]F or [Formula: see text]Ga) that decays via positron emission. The nearly collinear 511 keV annihilation gamma rays are detected in coincidence by a modified positron emission tomography (PET) camera, which defines their line of response (LOR). The chronologically measured LORs may then be used to triangulate the position of the moving tracer particle. We present an introduction to PEPT and illustrate the quality of measurements possible with a high-resolution PET scanner. Data are presented and discussed with reference to a few fundamental measurement scenarios and a framework for the metrology of PEPT is introduced.

scholarly journals [18F]fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing’s syndrome

2005 ◽  
Vol 152 (4) ◽  
pp. 521-525 ◽  
Author(s):  
Athina Markou ◽  
Patrick Manning ◽  
Banu Kaya ◽  
Sam N Datta ◽  
Jamshed B Bomanji ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Carcinoid Tumor ◽  
Fdg Pet ◽  
Pet Scan ◽  
Emission Tomography ◽  
Thymic Carcinoid ◽  
Acth Secretion ◽  
Positron Emission ◽  
Thymic Carcinoid Tumor

We report a case of a young woman with Cushing’s syndrome (CS), in whom although endocrine investigations and negative pituitary imaging were suggestive of ectopic ACTH secretion, the results of inferior petrosal sinus (IPS) sampling after coricotropin-releasing hormone (CRH) stimulation were suggestive of pituitary ACTH hypersecretion. 111In-labelled octreotide and high-resolution computer tomography (CT) revealed a lesion possibly responsible for the ACTH source in the thymus. Thymectomy confirmed concomitant ectopic CRH and probable ACTH production by a thymic neuroendocrine carcinoma. After an 8-year remission period the patient developed a clinical and biochemical relapse. A high-resolution computed tomography (CT) scan of the thorax showed a 2-cm nodule in the thymic bed, which was positive on a [18F]fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography (PET) scan. However, a repeated thymectomy did not result in remission. A repeat [18F]FDG PET study showed persistent disease in the thymic bed and also uptake in the adrenals. The patient underwent bilateral adrenalectomy, which resulted in clinical remission. A further [18F]FDG PET scan 8 months later showed no progression of the thymic tumor and confirmed complete excision of the adrenals. This is a rare case of concomitant CRH and ACTH secretion from a thymic carcinoid tumor; the case illustrates the usefulness of functional imaging with [18F]FDG PET in the diagnosis, management and follow-up of neuroendocrine tumors.

Design Considerations of Phoswich Detectors for High Resolution Positron Emission Tomography

2009 ◽  
Vol 56 (1) ◽  
pp. 182-188 ◽  
Author(s):  
Lars Eriksson ◽  
Charles L. Melcher ◽  
Marita Eriksson ◽  
Harold Rothfuss ◽  
Ron Grazioso ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Emission Tomography ◽  
Design Considerations ◽  
Positron Emission ◽  
Phoswich Detectors

Dopamine D2/3 receptor availability and human cognitive impulsivity: a high-resolution positron emission tomography imaging study with [11C]raclopride

2013 ◽  
Vol 26 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Jong-Hoon Kim ◽  
Young-Don Son ◽  
Hang-Keun Kim ◽  
Sang-Yoon Lee ◽  
Young-Bo Kim ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Animal Studies ◽  
Critical Role ◽  
Positron Emission Tomography Imaging ◽  
Imaging Study ◽  
Emission Tomography ◽  
Positron Emission ◽  
Character Inventory ◽  
Behavioural Aspects

ObjectiveHuman impulsivity is a complex multidimensional construct encompassing cognitive, emotional, and behavioural aspects. Previous animal studies have suggested that striatal dopamine receptors play a critical role in impulsivity. In this study, we investigated the relationship between self-reported impulsiveness and dopamine D2/3 receptor availability in striatal subdivisions in healthy subjects using high-resolution positron emission tomography (PET) with [11C]raclopride.MethodsTwenty-one participants completed 3-T magnetic resonance imaging and high-resolution PET scans with [11C]raclopride. The trait of impulsiveness was measured using the Barratt Impulsiveness Scale (BIS-11). Partial correlation analysis was performed between BIS-11 scores and D2/3 receptor availability in striatal subregions, controlling for the confounding effects of temperament characteristics that are conceptually or empirically related to dopamine, which were measured by the Temperament and Character Inventory.ResultsThe analysis revealed that the non-planning (p = 0.004) and attentional (p = 0.007) impulsiveness subscale scores on the BIS-11 had significant positive correlations with D2/3 receptor availability in the pre-commissural dorsal caudate. There was a tendency towards positive correlation between non-planning impulsiveness score and D2/3 receptor availability in the post-commissural caudate.ConclusionThese results suggest that cognitive subtrait of impulsivity is associated with D2/3 receptor availability in the associative striatum that plays a critical role in cognitive processes involving attention to detail, judgement of alternative outcomes, and inhibitory control.

scholarly journals Texture Analysis in the Diagnosis of Primary Breast Cancer: Comparison of High-Resolution Dedicated Breast Positron Emission Tomography (dbPET) and Whole-Body PET/CT

2020 ◽  
Vol 7 ◽  
Author(s):  
Yoko Satoh ◽  
Kenji Hirata ◽  
Daiki Tamada ◽  
Satoshi Funayama ◽  
Hiroshi Onishi
Keyword(s):  
Breast Cancer ◽  
Positron Emission Tomography ◽  
High Resolution ◽  
Texture Analysis ◽  
Texture Features ◽  
Emission Tomography ◽  
Whole Body ◽  
Tumor Characteristics ◽  
Positron Emission ◽  
Pet Ct

Objective: This retrospective study aimed to compare the ability to classify tumor characteristics of breast cancer (BC) of positron emission tomography (PET)-derived texture features between dedicated breast PET (dbPET) and whole-body PET/computed tomography (CT).Methods: Forty-four BCs scanned by both high-resolution ring-shaped dbPET and whole-body PET/CT were analyzed. The primary BC was extracted with a standardized uptake value (SUV) threshold segmentation method. On both dbPET and PET/CT images, 38 texture features were computed; their ability to classify tumor characteristics such as tumor (T)-category, lymph node (N)-category, molecular subtype, and Ki67 levels was compared. The texture features were evaluated using univariate and multivariate analyses following principal component analysis (PCA). AUC values were used to evaluate the diagnostic power of the computed texture features to classify BC characteristics.Results: Some texture features of dbPET and PET/CT were different between Tis-1 and T2-4 and between Luminal A and other groups, respectively. No association with texture features was found in the N-category or Ki67 level. In contrast, receiver-operating characteristic analysis using texture features' principal components showed that the AUC for classification of any BC characteristics were equally good for both dbPET and whole-body PET/CT.Conclusions: PET-based texture analysis of dbPET and whole-body PET/CT may have equally good classification power for BC.

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