scholarly journals Electropermanent magnet actuation for droplet ferromicrofluidics

TECHNOLOGY ◽  
2016 ◽  
Vol 04 (02) ◽  
pp. 110-119 ◽  
Author(s):  
José I. Padovani ◽  
Stefanie S. Jeffrey ◽  
Roger T. Howe
Keyword(s):  
Magnetic Fields ◽  
Water Droplet ◽  
Continuous Flow ◽  
Microfluidic System ◽  
Flow Conditions ◽  
Microfluidic Systems ◽  
Electromagnetic Actuation ◽  
On Demand ◽  
Current Pulses ◽  
Droplet Sorting

Droplet actuation is an essential mechanism for droplet-based microfluidic systems. On-demand electromagnetic actuation is used in a ferrofluid-based microfluidic system for water droplet displacement. Electropermanent magnets (EPMs) are used to induce 50 mT magnetic fields in a ferrofluid filled microchannel with gradients up to 6.4 × 104 kA/m2. Short 50 µs current pulses activate the electropermanent magnets and generate negative magnetophoretic forces that range from 10 to 70 nN on 40 to 80 µm water-in-ferrofluid droplets. Maximum droplet displacement velocities of up to 300 µm/s are obtained under flow and no-flow conditions. Electropermanent magnet-activated droplet sorting under continuous flow is demonstrated using a split-junction microfluidic design.

scholarly journals On-Demand Electrochemical Synthesis of copper(I) Triflate and Its Application in the Aerobic Oxidation of Alcohols

2021 ◽  
Author(s):  
Thomas P. Nicholls ◽  
Richard A. Bourne ◽  
Bao N. Nguyen ◽  
Nikil Kapur ◽  
Charlotte Willans
Keyword(s):  
Catalytic Oxidation ◽  
Electrochemical Synthesis ◽  
Continuous Flow ◽  
Aerobic Oxidation ◽  
Hydrogen Gas ◽  
Flow Conditions ◽  
On Demand ◽  
Major Benefit ◽  
Oxidation Of Alcohols ◽  
Work Up

<p>An on-demand electrochemical synthesis of copper(I) triflate under both batch and continuous flow conditions has been developed. A major benefit of the electrochemical methodology is that the only by-product of the reaction is hydrogen gas which obviates the need for work-up and purification, and water is not incorporated into the product. Upon completion of the electrochemical synthesis, solutions are directly transferred or dispensed into reaction mixtures for the catalytic oxidation of alcohols with no requirement for work-up or purification. </p>

scholarly journals High-Efficiency and High-Throughput On-Chip Exchange of the Continuous Phase in Droplet Microfluidic Systems

2017 ◽  
Vol 22 (5) ◽  
pp. 529-535 ◽  
Author(s):  
Minkyu Kim ◽  
Chia Min Leong ◽  
Ming Pan ◽  
Lucas R. Blauch ◽  
Sindy K. Y. Tang
Keyword(s):  
High Throughput ◽  
Continuous Flow ◽  
High Efficiency ◽  
Scale Up ◽  
Continuous Phase ◽  
Microfluidic System ◽  
Droplet Surface ◽  
Generation Process ◽  
Microfluidic Systems ◽  
On Chip

This article describes an integrated platform for the on-chip exchange of the continuous phase in droplet microfluidic systems. The drops used in this work are stabilized by amphiphilic nanoparticles. For some characterizations and applications of these nanoparticle-stabilized drops, including the measurement of adsorption dynamics of nanoparticles to the droplet surface, it is necessary to change the composition of the continuous phase from that used during the droplet generation process. Thus far, no work has reported the exchange of the continuous phase for a large number (>1 million) of drops in a microfluidic system. This article describes the design and characterization of a high-efficiency and high-throughput on-chip exchanger of the continuous phase in a continuous-flow droplet microfluidic system. The efficiency of exchange was higher than 97%. The throughput was greater than 1 million drops/min, and this can be increased further by increasing the number of parallel exchangers used. Because drops are injected into the exchanger in a continuous-flow manner, the method is directly compatible with automation to further increase its reliability and potential scale-up.

scholarly journals On-Demand Electrochemical Synthesis of copper(I) Triflate and Its Application in the Aerobic Oxidation of Alcohols

2021 ◽  
Author(s):  
Thomas P. Nicholls ◽  
Richard A. Bourne ◽  
Bao N. Nguyen ◽  
Nikil Kapur ◽  
Charlotte Willans
Keyword(s):  
Catalytic Oxidation ◽  
Electrochemical Synthesis ◽  
Continuous Flow ◽  
Aerobic Oxidation ◽  
Hydrogen Gas ◽  
Flow Conditions ◽  
On Demand ◽  
Major Benefit ◽  
Oxidation Of Alcohols ◽  
Work Up

<p>An on-demand electrochemical synthesis of copper(I) triflate under both batch and continuous flow conditions has been developed. A major benefit of the electrochemical methodology is that the only by-product of the reaction is hydrogen gas which obviates the need for work-up and purification, and water is not incorporated into the product. Upon completion of the electrochemical synthesis, solutions are directly transferred or dispensed into reaction mixtures for the catalytic oxidation of alcohols with no requirement for work-up or purification. </p>

On-demand synthesis of organozinc halides under continuous flow conditions

2018 ◽  
Vol 13 (2) ◽  
pp. 324-334 ◽  
Author(s):  
Mateo Berton ◽  
Lena Huck ◽  
Jesús Alcázar
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
On Demand

Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions

2019 ◽  
Vol 23 (3) ◽  
pp. 334-341 ◽  
Author(s):  
Zinia Jaman ◽  
Tiago J. P. Sobreira ◽  
Ahmed Mufti ◽  
Christina R. Ferreira ◽  
R. Graham Cooks ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
On Demand

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

scholarly journals Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

Tetrahedron ◽  
2021 ◽  
pp. 132305
Author(s):  
Harry R. Smallman ◽  
Jamie A. Leitch ◽  
Tom McBride ◽  
Steven V. Ley ◽  
Duncan L. Browne
Keyword(s):  
Continuous Flow ◽  
Flow Conditions

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

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