As the Fourth Industrial Revolution (I4.0) technologies continue to evolve and converge, the role of the managers needs to urgently adjust and change accordingly. While some are delighted with the promises of increased flexibility in industries in tandem with productivity and better quality, others are concerned with mass unemployment. This is a chilling vision of how robots will completely reshape industries and disrupt jobs, thus creating societal change of an unforeseen magnitude and speed. But one thing remains the same: management is the hinge on which the fate of every organization swings. Managers remain the key driver to build long-term success in organizations. In this context, managers need to deal with emerging challenges, opportunities, management practices brought about by the 4IR technologies. In this context, they have to address the six crucial transformations namely in technology, the pattern of work, business, society, lifelong learning, and leadership, and provide countermeasures to thrive within this brave new tech-driven and globalized business world.