scholarly journals Polymorphic System I

Author(s):  
Cristian F. Sottile ◽  
Alejandro Díaz-Caro ◽  
Pablo E. Martínez López
Keyword(s):  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali H. Ad’hiah ◽  
Risala H. Allami ◽  
Raghdan H. Mohsin ◽  
Maha H. Abdullah ◽  
Ali J. R. AL-Sa’ady ◽  
...  

Abstract Background Susceptibility to the pandemic coronavirus disease 2019 (COVID-19) has recently been associated with ABO blood groups in patients of different ethnicities. This study sought to understand the genetic association of this polymorphic system with risk of disease in Iraqi patients. Two outcomes of COVID-19, recovery and death, were also explored. ABO blood groups were determined in 300 hospitalized COVID-19 Iraqi patients (159 under therapy, 104 recovered, and 37 deceased) and 595 healthy blood donors. The detection kit for 2019 novel coronavirus (2019-nCoV) RNA (PCR-Fluorescence Probing) was used in the diagnosis of disease. Results Mean age was significantly increased in patients compared to controls (49.8 ± 11.7 vs. 28.9 ± 6.6 years; p < 0.001). A similar observation was made in recovered (42.1 ± 10.4 vs. 28.9 ± 6.6 years; p < 0.001) and deceased (53.6 ± 9.7 vs. 28.9 ± 6.6 years; p < 0.001) cases. The mean age was also significantly increased in deceased cases compared to recovered cases (53.6 ± 9.7 vs. 42.1 ± 10.4 years; p < 0.001). There were gender-dependent differences in COVID-19 prevalence. The percentage of COVID-19 was higher in males than in females (all cases: 59.7 vs. 40.3%; recovered cases: 55.8 vs. 44.2%). Such male-gender preponderance was more pronounced in deceased cases (67.6 vs. 32.4%). Logistic regression analysis revealed that groups AB and B + AB were significantly associated with increased risk to develop COVID-19 (OR = 3.10; 95% CI 1.59–6.05; pc = 0.007 and OR = 2.16; 95% CI 1.28–3.63; pc = 0.028, respectively). No ABO-associated risk was observed in recovered cases. On the contrary, groups A (OR = 14.60; 95% CI 2.85–74.88; pc = 0.007), AB (OR = 12.92; 95% CI 2.11–79.29; pc = 0.042), A + AB (OR = 14.67; 95% CI 2.98–72.33; pc = 0.007), and A + B + AB (OR = 9.67; 95% CI 2.02–46.24; pc = 0.035) were associated with increased risk of death in deceased cases. Conclusions The findings of this study suggest that group AB may be a susceptibility biomarker for COVID-19, while group A may be associated with increased risk of death.


Hereditas ◽  
2009 ◽  
Vol 75 (1) ◽  
pp. 153-155 ◽  
Author(s):  
I. Gustavsson ◽  
M. Hageltorn ◽  
L. Zech ◽  
S. Reiland

Author(s):  
Joel Bernstein

The intimate connection between structure and properties is particularly acute in establishing the effectiveness and safety of high energy materials based on molecular compounds: chemical and physical stability, shelf-life, sensitivity to shock, pressure, and temperature. Compared to other classes of compounds treated in the book for which the polymorphs with less suitable properties are not chosen for use, and thus relegated to lower importance, for high energy materials the risks and dangers of lack of familiarity and control of the polymorphic system can entail considerable long-term risks. The chapter is divided into two major sections distinguishing between aliphatic materials and the aromatic materials, commonly known by their alphabetic moniker. Throughout the chapter the history of the development of many of these materials is provided, including some rather obscure references culled from formerly classified government research reports. A detailed discussion of the classic enigmatic polymorphism of trinitrotoluene (TNT) is presented.


2008 ◽  
Vol 32 (10) ◽  
pp. 1747 ◽  
Author(s):  
Inna Barsky ◽  
Joel Bernstein ◽  
Peter W. Stephens ◽  
Kevin H. Stone

2015 ◽  
Vol 119 (19) ◽  
pp. 10178-10188 ◽  
Author(s):  
Xiao Tan ◽  
Kai Wang ◽  
Tingting Yan ◽  
Xiaodong Li ◽  
Jing Liu ◽  
...  

2018 ◽  
Vol 27 (5) ◽  
pp. 625-638
Author(s):  
Gilda Ferreira ◽  
Vasco T Vasconcelos

AbstractWe show that the number-theoretic functions definable in the atomic polymorphic system (${\mathbf{F}}_{\mathbf{at}}$) are exactly the extended polynomials. Two proofs of the above result are presented: one, reducing the functions’ definability problem in ${\mathbf{F}}_{\mathbf{at}}$ to definability in the simply typed lambda calculus ($\lambda ^{\rightarrow }$) and the other, directly adapting Helmut Schwichtenberg’s strategy for definability in $\lambda ^{\rightarrow }$ to the atomic polymorphic setting. The uniformity granted in the polymorphic system, when compared with the simply typed lambda calculus, is emphasized.


2013 ◽  
Vol 78 (1) ◽  
pp. 260-274 ◽  
Author(s):  
Fernando Ferreira ◽  
Gilda Ferreira

AbstractIt has been known for six years that the restriction of Girard's polymorphic system F to atomic universal instantiations interprets the full fragment of the intuitionistic propositional calculus. We firstly observe that Tait's method of “convertibility” applies quite naturally to the proof of strong normalization of the restricted Girard system. We then show that each β-reduction step of the full intuitionistic propositional calculus translates into one or more βη-reduction steps in the restricted Girard system. As a consequence, we obtain a novel and perspicuous proof of the strong normalization property for the full intuitionistic propositional calculus. It is noticed that this novel proof bestows a crucial role to η-conversions.


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