Enchondroma with pathologic fracture

CASE HISTORY G.R. is a 7-year-old boy with spastic quadriplegia evident since birth and a seizure disorder for which he currently is being treated with phenobarbitol and phenytoin (diphenylhydantoin). His medical history includes a pathologic fracture of his right femur. At the time of his fracture, a radiograph of his femur was described as "markedly osteoporotic." He is currently being treated with 1200 IU of vitamin D. His diet as presented is balanced with respect to nutrients. Although spillage is not substantial, eating requires great effort, and each meal lasts approximately 1 hour. He is fed breakfast and supper at home by his mother and lunch in school. There is no history of pain with food intake, no vomiting, and no diarrhea. He weighs 14 kg (far below the 5th percentile), and his length is 112 (at the 5th percentile). His weight for height is far less than the 5th percentile. His mother is 157.5 cm (5 ft 2 in) tall and his father is 167.5 cm (5 ft 6 in) tall. His midarm circumference is 154 mm (less than the 5th percentile), his triceps skinfold is 5 mm (5th percentile), and his midarm muscle circumference is 138 mm (less than the 5th percentile).

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A Cliniral Experience of Quadratus Femoris Muscle Pedicle Bone Graft in Nonunion and PatHologic Fracture of the Neck of Femur

Journal of the Korean Fracture Society ◽

10.12671/jksf.1992.5.2.383 ◽

1992 ◽

Vol 5 (2) ◽

pp. 383

Author(s):

C U Choi ◽

S K Rah ◽

Y S Seo ◽

S Y Choi ◽

D Y Kim

Keyword(s):

Bone Graft ◽

Pathologic Fracture ◽

Neck Of Femur ◽

Femoris Muscle ◽

Quadratus Femoris

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Aneurysmal Bone Cyst Involving the Pisiform: A Case Report

Hand ◽

10.1177/1558944716670615 ◽

2016 ◽

Vol 12 (5) ◽

pp. NP55-NP57

Author(s):

Eduardo P. Zancolli ◽

John M. Ranson ◽

Sunil M. Thirkannad

Keyword(s):

Bone Cyst ◽

Pathologic Fracture ◽

Surgical Excision ◽

Subsequent Treatment ◽

Uneventful Recovery ◽

Bone Cysts ◽

Primary Bone Tumors ◽

Ulnar Nerve Compression ◽

Left Hand ◽

Aneurysmal Bone Cysts

Background: Aneurysmal bone cysts are an uncommon form of benign primary bone tumors; affection of the hand is very rare. Methods: A rigorous review of the literature showed that this type of tumor has not previously been described in the pisiform. In this article, we report the occurrence of an aneurysmal bone tumor in the pisiform of the left hand of a 19-year-old male. Results: This tumor was successfully treated through surgical excision with an uneventful recovery. We describe the process behind the diagnosis of the lesion and the subsequent treatment in an attempt to highlight the rare but possible occurrence of aneurysmal bone cysts in the pisiform. Conclusion: Appropriate treatment of aneurysmal bone cysts in this location is required, due to the anatomical nature of the pisiform itself with the risks of pathologic fracture and ulnar nerve compression.

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Pathologic Fracture of the Femur in Brown Tumor Induced in Parathyroid Carcinoma: A Case Report

Hip & Pelvis ◽

10.5371/hp.2016.28.3.173 ◽

2016 ◽

Vol 28 (3) ◽

pp. 173 ◽

Cited By ~ 3

Author(s):

Sang-Hyun Park ◽

Gyu-Min Kong ◽

Yong-Uk Kwon ◽

Jun-Ho Park

Keyword(s):

Case Report ◽

Parathyroid Carcinoma ◽

Pathologic Fracture ◽

Brown Tumor

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Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement

Journal of The Royal Society Interface ◽

10.1098/rsif.2013.0962 ◽

2014 ◽

Vol 11 (93) ◽

pp. 20130962 ◽

Cited By ~ 76

Author(s):

S. B. Goodman ◽

E. Gibon ◽

J. Pajarinen ◽

T.-H. Lin ◽

M. Keeney ◽

...

Keyword(s):

Pathologic Fracture ◽

Wear Particle ◽

Wear Particles ◽

Implant Loosening ◽

Orthopaedic Implants ◽

Periprosthetic Osteolysis ◽

Joint Replacements ◽

Local Inhibition ◽

Tissue Healing ◽

Chronic Inflammatory Reaction

Wear particles and by-products from joint replacements and other orthopaedic implants may result in a local chronic inflammatory and foreign body reaction. This may lead to persistent synovitis resulting in joint pain and swelling, periprosthetic osteolysis, implant loosening and pathologic fracture. Strategies to modulate the adverse effects of wear debris may improve the function and longevity of joint replacements and other orthopaedic implants, potentially delaying or avoiding complex revision surgical procedures. Three novel biological strategies to mitigate the chronic inflammatory reaction to orthopaedic wear particles are reported. These include (i) interference with systemic macrophage trafficking to the local implant site, (ii) modulation of macrophages from an M1 (pro-inflammatory) to an M2 (anti-inflammatory, pro-tissue healing) phenotype in the periprosthetic tissues, and (iii) local inhibition of the transcription factor nuclear factor kappa B (NF-κB) by delivery of an NF-κB decoy oligodeoxynucleotide, thereby interfering with the production of pro-inflammatory mediators. These three approaches have been shown to be viable strategies for mitigating the undesirable effects of wear particles in preclinical studies. Targeted local delivery of specific biologics may potentially extend the lifetime of orthopaedic implants.

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