Clay Based Ionophore in PVC Membrane for their Application in Ion-Selective Electrodes

The fabrication and electrochemical evaluation of two PVC membrane-based Ion-Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril-phosphomolibdate and ramipril-tetraphenylborate ion-pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near-Nernestian response (sensitivity of53±0.5–54±0.5 mV/concentration decade) covering the concentration range of1.0×10-2–1.0×10-5 molL−1with a detection limit of3.0×10-6–4.0×10-6 molL−1. The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% (n=5).

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Validation of a Novel Potentiometric Method Based on a Polymeric PVC Membrane Sensor Integrated with Tailored Receptors for the Antileukemia Drug Cytarabine

Polymers ◽

10.3390/polym12061343 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1343 ◽

Cited By ~ 2

Author(s):

Ayman H. Kamel ◽

Abd El-Galil E. Amr ◽

Nashwa H. Ashmawy ◽

Hoda R. Galal ◽

Abdulrahman A. Almehizia ◽

...

Keyword(s):

Detection Limit ◽

Biological Fluid ◽

Pharmaceutical Formulations ◽

Assay Method ◽

Pvc Membrane ◽

Therapeutic Drug ◽

Ion Selective Electrodes ◽

Easy Method ◽

Potentiometric Response ◽

Sensory Element

A simple, rapid and easy method is proposed for the detection of a cytostatic therapeutic drug, cytarabine, in real samples. The method is based on potentiometric transduction using prepared and characterized new ion-selective electrodes for cytarabine. The electrodes were integrated with novel man-tailored imprinted polymers and used as a sensory element for recognition. The electrodes revealed a remarkable potentiometric response for cytarabine over the linearity range 1.0 × 10−6–1.0 × 10−3 M at pH 2.8–4 with a detection limit of 5.5 × 10−7 M. The potentiometric response was near-Nernstian, with average slopes of 52.3 ± 1.2 mV/decade. The effect of lipophilic salts and plasticizer types on the potentiometric response was also examined. The electrodes exhibited an enhanced selectivity towards cytarabine over various foreign common ions. Validation and verification of the presented assay method are demonstrated by evaluating the method ruggedness and calculating the detection limit, range of linearity, accuracy (trueness), precision, repeatability (within-day) and reproducibility (between-days). The proposed ion-selective electrodes revealed good performance characteristics and possible application of these electrodes for cytarabine monitoring in different matrices. The electrodes are successfully applied to cytarabine determination in spiked biological fluid samples and in pharmaceutical formulations.

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All-Solid-State, PVC Membrane, and Carbon Paste Ion-Selective Electrodes for Determination of Donepezil Hydrochloride in Pharmaceutical Formulation

Journal of AOAC International ◽

10.5740/jaoacint.16-0299 ◽

2017 ◽

Vol 100 (5) ◽

pp. 1414-1419

Author(s):

Nesreen Khamees ◽

Tagreed Abdel-Fattah Mohamed ◽

Abeer Rashad Derar ◽

Azza Aziz

Keyword(s):

Solid State ◽

Pharmaceutical Formulation ◽

Pvc Membrane ◽

Ion Selective Electrodes ◽

Carbon Paste ◽

Pharmaceutical Tablets ◽

Carbon Paste Electrodes ◽

Potentiometric Response ◽

Donepezil Hydrochloride

Abstract All-solid-state, polyvinyl chloride (PVC) membrane, and carbon paste potentiometric ion-selective electrodes (ISEs) were proposed for the determination of donepezil hydrochloride (DON) in the drug substance and a pharmaceutical formulation. The potentiometric response toward DON was based on the existence ofdonepezil-tetraphenyl borate (DON-TPB) in a PVC membrane or a carbon paste in the presence of dioctylphthalate. In contrast, the solid-state electrode was prepared by direct incorporation of DON-TPB into a commercial nail varnish without external additives. The electrodes exhibited Nernstian slopes of 55.0, 57.0, and 53.0 mV/decade over the concentration ranges of 1 × 10−5 to 1 × 10−3, 1 × 10−4 to 10−2, and 1 × 10−4 to 5 × 10−3 for the solid-state, PVC membrane, and carbon paste electrodes, respectively. The response of the electrodes is independent of pH in the range of 2–≤8. The electrodes showed good selectivity for DON with respect to a number of inorganic cations and amino acids. The electrodes were used for the determination of DON in pure solution and in pharmaceutical tablets with high accuracy (±2%) and precision (RSD ≤2%). The solid-state electrode is simple, economical, and rapid when compared to the PVC membrane and carbon paste electrodes.

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