Insulin-like growth factor-binding proteins and bone metabolism

2008 ◽  
Vol 294 (1) ◽  
pp. E10-E14 ◽  
Author(s):  
Cheryl A. Conover
Keyword(s):  
Cell Culture ◽  
Growth Factor ◽  
Bone Metabolism ◽  
Posttranslational Modifications ◽  
Clinical Studies ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Rodent Models ◽  
Factor Binding ◽  
Independent Effects

Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects. This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.

scholarly journals Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast.

1992 ◽  
Vol 267 (18) ◽  
pp. 12692-12699 ◽  
Author(s):  
M.C. Kiefer ◽  
C Schmid ◽  
M Waldvogel ◽  
I Schläpfer ◽  
E Futo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Insulin ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Recombinant Human Insulin ◽  
Factor Binding

Differential effects of thermal injury on circulating insulin-like growth factor binding proteins in burn patients

1994 ◽  
Vol 135 (2) ◽  
pp. 171-180 ◽  
Author(s):  
Aziz Ghahary ◽  
Stan Fu ◽  
You J. Shen ◽  
Heather A. Shankowsky ◽  
Edward E. Tredget
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Thermal Injury ◽  
Burn Patients ◽  
Insulin Like Growth Factor ◽  
Differential Effects ◽  
Factor Binding

scholarly journals Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes

2002 ◽  
Vol 62 (5) ◽  
pp. 1591-1600 ◽  
Author(s):  
Daniela Kiepe ◽  
Tim Ulinski ◽  
David R. Powell ◽  
Susan K. Durham ◽  
Otto Mehls ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Plate ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Growth Plate Chondrocytes ◽  
Differential Effects ◽  
Factor Binding

scholarly journals Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain

2005 ◽  
Vol 386 (1) ◽  
Author(s):  
Madhumita Ghosh ◽  
Sreejesh Shanker ◽  
Igor Siwanowicz ◽  
Karlheinz Mann ◽  
Werner Machleidt ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Purification and Characterization of Insulin-like Growth Factor Binding Proteins (IGF-BP) in Amniotic Fluid

1990 ◽  
Vol 66 (6) ◽  
pp. 636-648
Author(s):  
Mitsutoshi IWASHITA ◽  
Masako WATANABE ◽  
Tomoko ADACHI ◽  
Yoshihiko TAKEDA ◽  
Shoichi SAKAMOTO
Keyword(s):  
Growth Factor ◽  
Amniotic Fluid ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Purification And Characterization ◽  
Factor Binding
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