Endoscopic ultrasound-guided sampling and profiling of portal circulation in human patients for metabolic research studies and biomarker assessment

The technical aspects, feasibility, and safety of endoscopic ultrasound (EUS)-guided needle access for portal venous blood collection are presented in this technical report. Despite the very small diameter of the endoscopic needle, portal blood samples have the same quality as those collected from systemic circulation. As a proof of the concept and the utility of this technique in metabolic research and biomarker assessment and discovery, we present a pilot metabolite profiling study of portal venous blood in a small cohort of patients with cirrhosis and a comparison with a group without cirrhosis.

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Portal venous blood flow measurements by endoscopic ultrasound duplex scanning: validation against transit time ultrasound flowmetry

Clinical Physiology ◽

10.1046/j.1365-2281.1998.00004.x ◽

1998 ◽

Vol 18 (3) ◽

pp. 257-258

Author(s):

Hansen ◽

Becker ◽

Strandberg ◽

Højgård ◽

Madsen ◽

...

Keyword(s):

Blood Flow ◽

Transit Time ◽

Endoscopic Ultrasound ◽

Venous Blood ◽

Duplex Scanning ◽

Venous Blood Flow ◽

Flow Measurements ◽

Portal Venous Blood Flow ◽

Portal Venous Blood ◽

Blood Flow Measurements

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Comparison of a new device for blood sampling in cats with a vacuum tube collection system—Plasma biochemistry, haematology and practical usage assessment

Journal of Feline Medicine and Surgery ◽

10.1016/j.jfms.2007.03.006 ◽

2007 ◽

Vol 9 (5) ◽

pp. 382-386 ◽

Cited By ~ 10

Author(s):

Brice S Reynolds ◽

Karine G Boudet ◽

Mathieu R Faucher ◽

Claude Germain ◽

Anne Geffre ◽

...

Keyword(s):

Venous Blood ◽

Small Diameter ◽

Plasma Chemistry ◽

Blood Sampling ◽

Blood Collection ◽

Sampling Techniques ◽

Minimal Risk ◽

New Device ◽

Closed Systems ◽

Serious Injury

Using paediatric devices to collect venous blood from a cephalic vein in cats offers numerous practical advantages over traditional jugular venepuncture and vacuum closed systems: minimal restraint is required; there is minimal risk of serious injury to the cat; the discomfort associated with venepuncture is reduced by the use of small diameter (25 gauge) needles; very small volumes (200 μl) of blood are extracted; and the risk of vein collapse or haematoma is low. The aim of this study was to compare the haematological and plasma chemistry results obtained from six healthy cats using the two sampling techniques. Five plasma biochemical analytes were measured and a complete haematological examination was performed on each specimen. No clinically relevant difference between the two blood sampling techniques was observed for any variable, indicating that paediatric devices provide a useful alternative to vacuum tubes for venous blood collection in the cat.

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Endoscopic ultrasound-guided hepaticogastrostomy or hepaticojejunostomy without dilation using a stent with a thinner delivery system

Endoscopy International Open ◽

10.1055/a-1169-3749 ◽

2020 ◽

Vol 08 (08) ◽

pp. E1034-E1038

Author(s):

Kosuke Maehara ◽

Susumu Hijioka ◽

Yoshikuni Nagashio ◽

Akihiro Ohba ◽

Yuta Maruki ◽

...

Keyword(s):

Delivery System ◽

Endoscopic Ultrasound ◽

Clinical Success ◽

Small Diameter ◽

Stent Migration ◽

Metallic Stent ◽

Success Rates ◽

Ultrasound Guided ◽

Stent Occlusion ◽

Expandable Metallic Stent

Abstract Background and study aim Use of endoscopic ultrasound-guided biliary drainage (EUS-BD) has recently increased. In EUS-BD, after puncturing the bile duct, dilation is performed and the stent is deployed. Due to adverse events (AEs) such as unexpected displacement of the guidewire, simplified procedures are required. Currently, stents with small-diameter delivery systems are being rapidly developed, expanding the possibilities for of EUS-BD without dilation. In this retrospective study, we aimed to evaluate the success rates and AEs in patients who underwent EUS-guided hepaticogastrostomy (EUS-HGS) or EUS-guided hepaticojejunostomy (EUS-HJS) without dilation. Patients and methods Six consecutive patients with malignant biliary obstruction and failed transpapillary BD underwent EUS-HGS or EUS-HJS without dilation, deploying a 6-mm fully-covered self-expandable metallic stent with a 6-Fr delivery system. Results The technical and clinical success rates were 100 %. There was one case each of stent migration and stent occlusion, and no other AEs were noted. Conclusions EUS-HGS or EUS-HJS without dilation using a stent with a 6-Fr delivery system had high technical and clinical success rates; however, additional cases are required to validate the study findings.

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Transoral, transsphenoidal microsurgical exposure of the pituitary gland and infundibulum in the rhesus monkey

Journal of Neurosurgery ◽

10.3171/jns.1977.47.5.0663 ◽

1977 ◽

Vol 47 (5) ◽

pp. 663-669 ◽

Cited By ~ 3

Author(s):

George T. Tindall ◽

John Patton ◽

Jimmy D. Neill

Keyword(s):

Rhesus Monkey ◽

Venous Blood ◽

Practical Method ◽

Pituitary Stalk ◽

Blood Collection ◽

Posterior Lobe ◽

Content Type ◽

Microsurgical Technique ◽

Portal Venous Blood ◽

Fine Print

✓ A transoral, transsphenoidal microsurgical technique for exposing the pituitary stalk and gland of the rhesus monkey is described and illustrated. The technique has proved to be a safe and practical method for performing a variety of pituitary operations in a total of 37 animals. The procedures have included complete hypophysectomy, posterior lobe resection, pituitary stalk section, collection of portal venous blood, collection of pituitary venous blood, and placement of lesions in the organum vasculosum of the lamina terminalis.

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