ULTRASTRUCTURE OF THE ABDOMINAL PLEXUS OF RATS DURING HERBICIDE INTOXICATION AND TREATMENT

As a result of the study, it was found that poisoning of rats with the herbicide 2,4 - DA for 4 weeks causes a decrease in the number of neurocytes in the celiac plexus, changes the protein synthesizing and energy systems of the cell, and accumulates residual structures in the form of lipofuscin. In the neuroplasm, the number of neurofilaments and neurotubules decreases, the organization of the myelin layer of fibers is disrupted. Changes affect the structure of the intima and media of blood vessels, leading to a violation of their transport function. When rats are treated with Taktivin, they show positive dynamics in the structure of the celiac plexus; the protein-synthesizing system is restored in the nuclei and neuroplasm of a number of cells. In the connective tissue stroma, the ultrastructure of collagen fibers improves, and the number of blood vessels increases.

Emergence agitation after intraoperative neurolytic celiac plexus block with alcohol: a case report

Background Emergence agitation after general anesthesia may cause several undesirable events in the clinic during patient anesthesia recovery, and acute alcohol intoxication, while rare in surgery, is one of the risk factors. Case presentation A 66-year-old male patient was found to have pancreatic tail neoplasm upon computed tomography (CT) examination. The surgeon planned to resect the pancreatic tail under general anesthesia. However, the surgeon found extensive tumor metastasis in the abdominal cavity, and thus performed a neurolytic celiac plexus block (NCPB) with 40 ml 95% ethyl alcohol and finished the surgery in approximately 1 h. Twenty minutes later, the patient was extubated and developed significant emergence agitation in the postoperative care unit, characterized by restlessness, uncontrollable movements, confusion and disorientation. The patient was flushed and febrile with an alcohol smell in his breath and was unable to follow commands. Patient symptoms were suspected to be due to acute alcohol intoxication. Thus, the patient was given 40 mg of propofol intravenously. Following treatment, the patient recovered with less confusion and disorientation after approximately 10 min. After treatment with propofol twice more, he regained consciousness, was calm and cooperative, had no pain, and could obey instructions approximately 1 h and 40 min following the last treatment. Following this treatment, the patient was transferred to the inpatient ward and felt well. Conclusions It is paramount to correctly identify the underlying cause of emergence agitation in order to successfully manage patient symptoms, since treatment plans vary between different etiological causes. Emergence agitation may be due to acute alcohol intoxication after intraoperative use of alcohol.