Cerebrospinal fluid acid-base balance during respiratory alkalosis in the panting animal

To test the passive transport hypothesis of cerebrospinal fluid (CSF) [H+] regulation, we altered the relationship between plasma [H+] and the electrical potential difference between CSF and blood (PD) by elevating plasma [K+] during 6-h systemic acid-base disturbances. In five groups of pentobarbital-anesthetized dogs, we increased plasma [K+] from 3.5 to an average of 7.8 meq/l. Hyperkalemia produced an increase in the PD of 6.3 mV by 6 h with normal plasma acid-base status (pHa 7.4), of 8.3 mV with isocapnic metabolic acidosis (pHa 7.2), of 5.3 mV with isocapnic metabolic alkalosis (pHa 7.6), of 9.2 mV with isobicarbonate respiratory acidosis (PaCO2 61 Torr) and of 5.7 mV with isobicarbonate respiratory alkalosis (PaCO2 25 Torr). The change in CSF [H+] at 6 h in each group was the same as that observed in normokalemic animals (Am. J. Physiol. 228: 1134-1154, 1975). This result is not consistent with the passive transport hypothesis. The CSF-blood PD is therefore not an important determinant of CSF [H+] CSF [H+] homeostasis must result from some form of active transport control.

Download Full-text

Acid-Base Balance in Cerebrospinal Fluid

Archives of Neurology ◽

10.1001/archneur.1965.00460290035006 ◽

1965 ◽

Vol 12 (5) ◽

pp. 479-496 ◽

Cited By ~ 104

Author(s):

J. B. POSNER ◽

A. G. SWANSON ◽

F. PLUM

Keyword(s):

Cerebrospinal Fluid ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance

Download Full-text

Practical Evaluation of Acid-Base Balance

Clinical Chemistry ◽

10.1093/clinchem/3.5.631 ◽

1957 ◽

Vol 3 (5) ◽

pp. 631-637

Author(s):

Herbert P Jacobi ◽

Anthony J Barak ◽

Meyer Beber

Keyword(s):

Respiratory Acidosis ◽

Respiratory Alkalosis ◽

Acid Base Balance ◽

Bicarbonate Concentration ◽

Acid Base ◽

Plasma Bicarbonate ◽

Practical Evaluation ◽

Base Balance

Abstract The Co2 combining power bears a variable relationship to the in vivo plasma bicarbonate concentration, depending upon the type and severity of acid-base distortion. In respiratory alkalosis and metabolic acidosis the Co2 combining power will usually be greater than the in vivo plasma bicarbonate concentration; whereas, in respiratory acidosis and metabolic alkalosis the Co2 combining power will usually be less. Co2 content, on the other hand, will always parallel the in vivo plasma bicarbonate concentration quite closely, being only slightly greater. These facts, together with other considerations which are discussed, recommend the abandonment of the determination of CO2 combining power.

Download Full-text

The effect of heat stress on respiratory alkalosis, blood acid base balance and insulin sensitivity in cinnamon supplemented pigs

Animal Production Science ◽

10.1071/anv57n12ab043 ◽

2017 ◽

Vol 57 (12) ◽

pp. 2415

Author(s):

J. J. Cottrell ◽

F. Liu ◽

S. Wan ◽

U. A. Wijesiriwardana ◽

K. DiGiacomo ◽

...

Keyword(s):

Heat Stress ◽

Insulin Sensitivity ◽

Respiratory Alkalosis ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance

Download Full-text

Mechanism of Erythropoietin Production by Cobaltous Chloride

Blood ◽

10.1182/blood.v44.3.339.339 ◽

1974 ◽

Vol 44 (3) ◽

pp. 339-346 ◽

Cited By ~ 6

Author(s):

Marilyn E. Miller ◽

Donald Howard ◽

Frederick Stohlman ◽

Patricia Flanagan

Keyword(s):

Respiratory Alkalosis ◽

Sprague Dawley ◽

Acid Base Balance ◽

Acid Base ◽

Erythropoietin Production ◽

Sprague Dawley Rats ◽

Base Balance ◽

Subsequent Effect ◽

Significant Measure ◽

Dose Levels

Abstract Normal and nephrectomized Sprague-Dawley rats were treated with CoCl2 at three dose levels, 10, 20, and 25 µm/ 100 g body weight. The effects of this drug on acid-base balance were related to the production of erythropoietin. Within 6 hr after the administration of CoCl2 to normal rats, a dose-related respiratory alkalosis occurred associated with an increase in the affinity of hemoglobin for oxygen. This was followed by an increase in the production of erythropoietin. Nephrectomy altered the acid-base balance of the animal such that a profound acidosis occurred after the administration of CoCl2 with an associated decrease in the affinity of hemoglobin for oxygen. Erythropoietin could not be detected in these nephrectomized rats given CoCl2. These findings demonstrate that the production of erythropoietin after the administration of CoCl2 is related in significant measure to changes in acid-base balance with its subsequent effect on the affinity of hemoglobin for oxygen.

Download Full-text