The characteristics of mesenteric adipose tissue attached to different intestinal segments and their roles in immune regulation

Background: Mesenteric adipose tissue (MAT) plays a critical role in the intestinal physiological ecosystems. Small and large intestines have evidently intrinsic and distinct characteristics. However, whether there exist any mesenteric differences adjacent to the small and large intestines (SMAT and LMAT) has not been properly characterized. We studied the important facets of these differences, such as morphology, gene expression, cell components and immune regulation of MATs, to characterize the mesenteric differences. Methods: The SMAT and LMAT of mice were utilized for comparison of tissue morphology. Paired mesenteric samples were analyzed by RNA-seq to clarify gene expression profiles. MAT partial excision models were constructed to illustrate the immune regulation roles of MATs, and 16S-seq was applied to detect the subsequent effect on microbiota. Results: Our data show that different segments of mesenteries have different morphological structures. SMAT not only has smaller adipocytes but also contains more fat-associated lymphoid clusters than LMAT. The gene expression profile is also discrepant between these two MATs in mice. B-cell markers were abundantly expressed in SMAT, while development-related genes were highly expressed in LMAT. Adipose-derived stem cells of LMAT exhibited higher adipogenic potential and lower proliferation rates than those of SMAT. In addition, SMAT and LMAT play different roles in immune regulation and subsequently affect microbiota components. Finally, our data clarified the described differences between SMAT and LMAT in humans. Conclusions: There were significant differences in cell morphology, gene expression profiles, cell components, biological characteristics, and immune and microbiota regulation roles between regional MATs.

Demystifying the Effect of Flow Experience for Mobile App-based E-Services

The purpose of this paper is to understand the consumer behavior by investigating the effect of flow experience and marketing mix on consumers continued intention to use e-services provided through mobile applications and subsequent effect on consumers loyalty. The study also tests through a moderated mediation approach, the mediation of continued intention to use between flow experience-marketing mix and consumers loyalty while considering the moderating role of e-trust and privacy concern with the application. An online survey was conducted to collect data from the consumers, obtaining 405 valid samples which were analyzed using multiple regression to test the conceptual model of this study. The findings support that flow experience in mobile apps increases consumes intention to use, which is a significant predictor for consumer loyalty for services availed through mobile apps. This study provides insights for the marketers to build the flow in the mobile apps with interactive features, aesthetic design and ease of use to drive for continued intention to use and loyalty.

An Intersectionality Perspective on Rural Adolescent Access to Digital Technology in South Africa

The recent COVID-19 pandemic has brought to the fore compounding disparities in the South African education system. The world at large has suddenly been faced with the challenge of blended learning given that COVID-19 has reconstituted the traditional form of education delivery. Much emphasis has been placed on global education, yet due to compounding inequalities stemming from the effects of apartheid, the South African education system has been left further entrenched in the digital divide. It is for this reason that the authors of this chapter illuminate the lack of digital technology, its subsequent effect on adolescents in rural areas, and how it impacts on their ability to learn and compete in the global education sphere. The perspective of Intersectionality theory highlighted in this chapter is used to address the inequalities perpetuated by digital technology on adolescents in rural areas.

Demystifying the Effect of Flow Experience for Mobile App-based E-Services

The purpose of this paper is to understand the consumer behavior by investigating the effect of flow experience and marketing mix on consumers continued intention to use e-services provided through mobile applications and subsequent effect on consumers loyalty. The study also tests through a moderated mediation approach, the mediation of continued intention to use between flow experience-marketing mix and consumers loyalty while considering the moderating role of e-trust and privacy concern with the application. An online survey was conducted to collect data from the consumers, obtaining 405 valid samples which were analyzed using multiple regression to test the conceptual model of this study. The findings support that flow experience in mobile apps increases consumes intention to use, which is a significant predictor for consumer loyalty for services availed through mobile apps. This study provides insights for the marketers to build the flow in the mobile apps with interactive features, aesthetic design and ease of use to drive for continued intention to use and loyalty.

Demystifying the Effect of Flow Experience for Mobile App-based E-Services

The purpose of this paper is to understand the consumer behavior by investigating the effect of flow experience and marketing mix on consumers continued intention to use e-services provided through mobile applications and subsequent effect on consumers loyalty. The study also tests through a moderated mediation approach, the mediation of continued intention to use between flow experience-marketing mix and consumers loyalty while considering the moderating role of e-trust and privacy concern with the application. An online survey was conducted to collect data from the consumers, obtaining 405 valid samples which were analyzed using multiple regression to test the conceptual model of this study. The findings support that flow experience in mobile apps increases consumes intention to use, which is a significant predictor for consumer loyalty for services availed through mobile apps. This study provides insights for the marketers to build the flow in the mobile apps with interactive features, aesthetic design and ease of use to drive for continued intention to use and loyalty.

Long-Term Observations of Schumann Resonances at Portishead (UK)

Constructive interference of lightning-generated signals in the extremely low frequency (ELF) below 100 Hz is the source of a global electromagnetic phenomenon in the Earth’s atmosphere known as Schumann Resonances (SR). SR are excited at frequencies of 7.8, 14, 20, 26, … Hz, and their diurnal and seasonal intensity variations are largely dependent on changes in the location and magnitude of the major lightning centres in Southeast Asia, Africa, and South America. In the last five decades, extensive research has focused on reconstructing the spatial and temporal evolution in global lighting activity using SR measurements, and more recently on analysing the links to climate change, transient luminous events (TLE), and biological systems. In this study, a quasi-electrostatic antenna, primarily designed as a thunderstorm warning system, is for the first time applied to measure background variability in the SR band at an urban site in Southwest England. Data collected continuously from June 2015 for a 5-year period are suitably filtered and analysed showing that SR is the dominant contribution to the fair-weather displacement current measured by the sensor in the band 10–45 Hz. Diurnal and seasonal signal amplitude variations have been found to be consistent with previous studies and show the African-European lightning centre to prevail due to the shorter source-observer distance. Also, it is shown that long-term global changes in the ocean and land temperature, and the subsequent effect on the major lightning hotspots, may be responsible for the inter-annual variability of SR intensity, indicating that the largest increase occurred during the 2015–2016 super El-Niño episode.

A Critical Appraisal of the Use and Properties of Nickel–Titanium Dental Alloys

Nickel–titanium (NiTi) archwires are used in dentistry for orthodontic treatment. NiTi alloys have favourable mechanical characteristics, such as superelasticity and shape memory, and are also known as a corrosion-resistant alloy. In specific cases, an archwire could be attacked by certain types of corrosion or wear degradation, which can cause the leaching of metal ions and a hypersensitive response due to increased concentrations of Ni in the human body. A systematic search of the literature retrieved 102 relevant studies. The review paper focuses on three main fields: (i) electrochemical properties of NiTi wires and the effect of different environments on the properties of NiTi wires (fluoride and low pH); (ii) tribocorrosion, a combination of chemical and mechanical wear of the material, and (iii) the biocompatibility of NiTi alloy and its subsequent effect on the human body. The review showed that corrosion properties are affected by microstructure, pH of saliva and the presence of fluorides. A high variation in published results should be, therefore, interpreted with care. The release of nickel ions was assessed using the same unit, showing that the vast majority of metal ions were released in the first few days of exposure, then a stable, steady state was reached. In tribocorrosion studies, the increased concentrations of Ni ions were reported.

Child Birth and its Effect on Functional Status of Women: A Review

Though highly satisfying motherhood comes with its own challenges. Often underestimated, the effect of child birth on maternal function is a huge and can invariably effect not only the individual but the society in general. Yet there seems to be an attitude of “its all part and parcel of motherhood” when it comes to the functional status of mothers. To improve the functional status of women one needs to quantify it and a scale for Indian mothers are not in existence yet. No matter the mode of delivery , the maternal function is compromised, its said that the physiological healing is complete at 6 weeks post delivery but the researchers are not able to come to terms regarding time needed to achieve the pre pregnancy functional status or in many cases if it ever returns. Hence the gravity of situation is dare and needs acknowledgment not only from the health care professionals but from the society in general. In this article, we are examining the different modes of delivery and its subsequent effect on physical functions of women.

Effect of Greenhouse Cladding Materials and Thermal Screen Configuration on Heating Energy and Strawberry (Fragaria ananassa var. “Seolhyang”) Yield in Winter

Strawberry cultivation depends on environmental factors, making its cultivation in the greenhouse a challenge in the winter. This study investigated the most appropriate greenhouse cladding material and thermal screen configuration for strawberry production in the winter by considering greenhouse air temperature, relative humidity (RH, vapor pressure deficit (VPD, and solar radiation (SR). Two gothic greenhouses with different cladding materials and thermal screen configurations, namely, the single-layer greenhouse and double-layer greenhouse, were used for strawberry cultivation. The greenhouse microclimate was controlled by natural ventilation aided with circulating fans and boilers. Strawberries were planted on 5 greenhouse benches, 660 stands per greenhouse. Daily environmental parameters were recorded and processed into daytime and nighttime. The impacts of cladding material-thermal screen configurations on temperature, RH, VPD, and SR, and the subsequent effect on strawberry yield in both greenhouse systems, were evaluated. Comparing the environmental parameters recorded in the single-layer and double-layer greenhouse showed that VPD and SR were significantly different in the daytime, whereas RH and VPD were significantly different in the nighttime. The post hoc test further showed that RH, VPD, and SR in both greenhouses were significantly different. The significant difference in RH and VPD can be attributed to the inner layer of polyethene in the double-layer greenhouse, which sealed up the pores of the thermal screen, resulting in humidity buildup, causing a lower VPD than in the single-layer greenhouse. The single-layer greenhouse yield was 14% greater than the double-layer greenhouse yield and can be attributed to the higher daytime VPD and lower RH achieved in the single-layer greenhouse at night. The study established that though the single-layer greenhouse system was cost-effective regarding construction, the operating cost of the single-layer greenhouse was higher than that of the double-layer greenhouse.