scholarly journals Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia

2021 ◽  
Author(s):  
Mada Ghanem ◽  
Méline Homps-Legrand ◽  
Marc Garnier ◽  
Lise Morer ◽  
Tiphaine Goletto ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Median Percentage ◽  
Icu Patients ◽  
Risk Of Death ◽  
Serum Amyloid P ◽  
Increased Risk ◽  
Fibrotic Lung Diseases ◽  
Amyloid P ◽  
Lung Ct ◽  
Circulating Fibrocytes

Increased blood fibrocytes are associated with a poor prognosis in fibrotic lung diseases. We aimed to determine whether the percentage of circulating fibrocytes could be predictive of severity and prognosis during Coronavirus disease 2019 (COVID-19) pneumonia. Blood fibrocytes were quantified by flow cytometry as CD45+/CD15-/CD34+/Collagen-1+cells in patients hospitalized for COVID-19 pneumonia. In a subgroup of patients admitted in ICU, fibrocytes were quantified in blood and broncho-alveolar lavage (BAL). Serum amyloid P (SAP), TGF-b1,CXCL12, CCL2, and FGF2 serum concentration were measured in serum. We included 57 patients in the Hospitalized group (median age 59 years [23-87]) and 16 Healthy controls. The median percentage of circulating fibrocytes was higher in patients compared to controls (3.6% [0.2-9.2] vs. 2.1% [0.9-5.1], p=0.04). Blood fibrocyte count was lower in the 6 patients who died compared to survivors (1.6% [0.2-4.4] vs. 3.7% [0.6-9.2], p=0.02). Initial fibrocyte count was higher in patients showing a complete lung CT resolution at 3 months. Circulating fibrocyte count was decreased in the ICU group (0.8% [0.1-2.0]) whereas BAL fibrocyte count was 6.7% [2.2-15.4]. Serum SAP and TGF-b1 concentrations were increased in Hospitalized patients. SAP was also increased in ICU patients. CXCL12 and CCL2 were increased in ICU patients, and negatively correlated with circulating fibrocyte count. We conclude that circulating fibrocytes were increased in patients hospitalized for COVID-19 pneumonia and a lower fibrocyte count was associated with an increased risk of death and a slower resolution of lung CT opacities.

scholarly journals The natural history of progressive fibrosing interstitial lung diseases

2020 ◽  
Vol 55 (6) ◽  
pp. 2000085 ◽  
Author(s):  
Kevin K. Brown ◽  
Fernando J. Martinez ◽  
Simon L.F. Walsh ◽  
Victor J. Thannickal ◽  
Antje Prasse ◽  
...  
Keyword(s):  
Natural History ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Hazard Ratio ◽  
P Value ◽  
Risk Of Death ◽  
Increased Risk ◽  
History Of ◽  
Relative Decline ◽  
Rate Of Decline

We used data from the INBUILD and INPULSIS trials to investigate the natural history of progressive fibrosing interstitial lung diseases (ILDs).Subjects in the two INPULSIS trials had a clinical diagnosis of idiopathic pulmonary fibrosis (IPF) while subjects in the INBUILD trial had a progressive fibrosing ILD other than IPF and met protocol-defined criteria for ILD progression despite management. Using data from the placebo groups, we compared the rate of decline in forced vital capacity (FVC) (mL·year−1) and mortality over 52 weeks in the INBUILD trial with pooled data from the INPULSIS trials.The adjusted mean annual rate of decline in FVC in the INBUILD trial (n=331) was similar to that observed in the INPULSIS trials (n=423) (−192.9 mL·year−1 and −221.0 mL·year−1, respectively; nominal p-value=0.19). The proportion of subjects who had a relative decline in FVC >10% predicted at Week 52 was 48.9% in the INBUILD trial and 48.7% in the INPULSIS trials, and the proportion who died over 52 weeks was 5.1% in the INBUILD trial and 7.8% in the INPULSIS trials. A relative decline in FVC >10% predicted was associated with an increased risk of death in the INBUILD trial (hazard ratio 3.64) and the INPULSIS trials (hazard ratio 3.95).These findings indicate that patients with fibrosing ILDs other than IPF, who are progressing despite management, have a subsequent clinical course similar to patients with untreated IPF, with a high risk of further ILD progression and early mortality.

scholarly journals Fluctuations in serum sodium level are associated with an increased risk of death in surgical ICU patients

Critical Care ◽  
2012 ◽  
Vol 16 (S1) ◽  
Author(s):  
Y Sakr ◽  
S Rother ◽  
AM Ferreira ◽  
C Ewald ◽  
P Dünich ◽  
...  
Keyword(s):  
Serum Sodium ◽  
Sodium Level ◽  
Serum Sodium Level ◽  
Icu Patients ◽  
Risk Of Death ◽  
Increased Risk ◽  
Surgical Icu

Fluctuations in Serum Sodium Level Are Associated With an Increased Risk of Death in Surgical ICU Patients*

2013 ◽  
Vol 41 (1) ◽  
pp. 133-142 ◽  
Author(s):  
Yasser Sakr ◽  
Steffen Rother ◽  
Alberto Mendonca Pires Ferreira ◽  
Christian Ewald ◽  
Pedro Dünisch ◽  
...  
Keyword(s):  
Serum Sodium ◽  
Sodium Level ◽  
Serum Sodium Level ◽  
Icu Patients ◽  
Risk Of Death ◽  
Increased Risk ◽  
Surgical Icu

scholarly journals First Identification of Resident and Circulating Fibrocytes in Dupuytren’s Disease Shown to Be Inhibited by Serum Amyloid P and Xiapex

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99967 ◽  
Author(s):  
Syed Amir Iqbal ◽  
Michael John Hayton ◽  
James Stewart Watson ◽  
Piotr Szczypa ◽  
Ardeshir Bayat
Keyword(s):  
Serum Amyloid ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Serum Amyloid P ◽  
Amyloid P ◽  
Circulating Fibrocytes

scholarly journals Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

Critical Care ◽  
2015 ◽  
Vol 19 (1) ◽  
Author(s):  
Pierre Kalfon ◽  
◽  
Yannick Le Manach ◽  
Carole Ichai ◽  
Nicolas Bréchot ◽  
...  
Keyword(s):  
Icu Patients ◽  
Risk Of Death ◽  
Increased Risk

scholarly journals Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252206
Author(s):  
Samuel H. Belok ◽  
Nicholas A. Bosch ◽  
Elizabeth S. Klings ◽  
Allan J. Walkey
Keyword(s):  
Organ Dysfunction ◽  
Medical Information ◽  
Small Subset ◽  
Icu Patients ◽  
Suspected Infection ◽  
Risk Of Death ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Multivariable Regression ◽  
Multivariable Regression Models

Background Although both leukocytosis and leukopenia have been considered Systemic Inflammatory Response Syndrome criteria, leukopenia is not generally considered a normal response to infection. We sought to evaluate the prognostic validity of leukopenia as a sign of sepsis-defining hematological organ dysfunction within the Sepsis-3 framework. We hypothesized that leukopenia is associated with higher risk of mortality than leukocytosis among patients with suspected infection. Methods We performed a retrospective cohort study using the Medical Information Mart v1.4 in Intensive Care-III database. Multivariable regression models were used to evaluate the association between leukopenia and mortality in patients with suspected infection defined by Sepsis-3. Results We identified 5,909 ICU patients with suspected infection; 250 (4.2%) had leukopenia. Leukopenia was associated with increased in-hospital mortality compared with leukocytosis (OR, 1.5; 95% CI 1.1–1.9). After adjusting for demographics and comorbidities in the Sepsis-3 consensus model, leukopenia remained associated with increased risk of mortality compared with leukocytosis (OR 1.6, 95% CI 1.2–2.2). Further adjustment for the platelet component of the SOFA attenuated the association between leukopenia and mortality (OR decreased from 1.5 to 1.1). However, 83 (1.4%) of patients had leukopenia without thrombocytopenia and 14 had leukopenia prior to thrombocytopenia. Conclusions Among ICU patients with suspected infection, leukopenia was associated with increased risk of death compared with leukocytosis. Due to correlation with thrombocytopenia, leukopenia did not independently improve the prognostic validity of SOFA; however, leukopenia may present as a sign of sepsis prior to thrombocytopenia in a small subset of patients.

Lung Function and Quality of Life in Workers with Chemical and Dust Exposure

2018 ◽  
Vol 69 (2) ◽  
pp. 346-349 ◽  
Author(s):  
Marina Ruxandra Otelea ◽  
Oana Cristina Arghir ◽  
Corina Zugravu ◽  
Eugenia Naghi ◽  
Sabina Antoniu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Occupational Exposure ◽  
Lung Function ◽  
Lung Diseases ◽  
Dust Exposure ◽  
Chronic Lung Diseases ◽  
Respiratory Exposure ◽  
Increased Risk ◽  
Occupational Settings

Regarding the widely distribution of respiratory exposure hazards in occupational settings, workers have an increased risk for chronic lung diseases. For assessing the quality of life and lung function in workers exposed to chemicals and dust, St George�s Respiratory Questionnaire (SGRQ) and spirometry were performed among 40 patients, admitted in Occupational Clinic Department of Colentina Hospital, Bucharest, Romania, during February, 2017. SGRQ showed different predictors for patients according to their occupational exposure and total symptoms score correlated better with decreased spirometric parameters in defining lung function deterioration. Quality of life is earlier affected than lung function deterioration and emphasises the need of more sensitive methods for an earlier identification and better evaluation of respiratory hazards in different workplaces.

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