Variation in the gene Tas1r3 reveals complex temporal properties of mouse brainstem taste responses to sweeteners

2021 ◽  
Author(s):  
Stuart A. McCaughey
Keyword(s):  
Sweet Taste ◽  
Current Data ◽  
Burst Firing ◽  
Group Differences ◽  
Solitary Tract ◽  
Neural Responses ◽  
Phasic Response ◽  
Temporal Properties ◽  
Spatio Temporal ◽  
Activity Dependent

The gene Tas1r3 codes for the protein T1R3, which dimerizes with T1R2 to form a sweetener-binding receptor in taste cells. Tas1r3 influences sweetener preferences in mice, as shown by work with a 129.B6-Tas1r3 segregating congenic strain on a 129P3/J (129) genetic background; members of this strain vary in whether they do or do not have one copy of a donor fragment with the C57BL/6ByJ (B6) allele for Tas1r3 (B6/129 and 129/129 mice, respectively). Taste-evoked neural responses were measured in the nucleus of the solitary tract (NST), the first central gustatory relay, in B6/129 and 129/129 littermates, in order to examine how the activity dependent on the T1R2/T1R3 receptor is distributed across neurons and over time. Responses to sucrose were larger in B6/129 than in 129/129 mice, but only during a later, tonic response portion (> 600 ms) sent to different cells than the earlier, phasic response. Similar results were found for artificial sweeteners, whose responses were best considered as complex spatio-temporal patterns. There were also group differences in burst firing of NST cells, with a significant positive correlation between bursting prevalence and sucrose response size in only the 129/129 group. The results indicate that sweetener transduction initially occurs through T1R3-independent mechanisms, after which the T1R2/T1R3 receptor initiates a separate, spatially-distinct response, with the later period dominating sweet taste perceptions and driving sugar preferences. Furthermore, the current data suggest that burst firing is distributed across NST neurons non-randomly and in a manner that may amplify weak incoming gustatory signals.

scholarly journals A spatio-temporal specification language and its completeness & decidability

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Tengfei Li ◽  
Jing Liu ◽  
Haiying Sun ◽  
Xiang Chen ◽  
Lipeng Zhang ◽  
...  
Keyword(s):  
Intelligent Transportation System ◽  
Cyber Physical Systems ◽  
Specification Language ◽  
Finite Model ◽  
Critical Systems ◽  
Physical Systems ◽  
Spatial Objects ◽  
Temporal Properties ◽  
Spatio Temporal ◽  
Temporal Specification

AbstractIn the past few years, significant progress has been made on spatio-temporal cyber-physical systems in achieving spatio-temporal properties on several long-standing tasks. With the broader specification of spatio-temporal properties on various applications, the concerns over their spatio-temporal logics have been raised in public, especially after the widely reported safety-critical systems involving self-driving cars, intelligent transportation system, image processing. In this paper, we present a spatio-temporal specification language, STSL PC, by combining Signal Temporal Logic (STL) with a spatial logic S4 u, to characterize spatio-temporal dynamic behaviors of cyber-physical systems. This language is highly expressive: it allows the description of quantitative signals, by expressing spatio-temporal traces over real valued signals in dense time, and Boolean signals, by constraining values of spatial objects across threshold predicates. STSL PC combines the power of temporal modalities and spatial operators, and enjoys important properties such as finite model property. We provide a Hilbert-style axiomatization for the proposed STSL PC and prove the soundness and completeness by the spatio-temporal extension of maximal consistent set and canonical model. Further, we demonstrate the decidability of STSL PC and analyze the complexity of STSL PC. Besides, we generalize STSL to the evolution of spatial objects over time, called STSL OC, and provide the proof of its axiomatization system and decidability.

Spatio-temporal visual properties in the ascending tectofugal system

2010 ◽  
Vol 5 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Alice Rokszin ◽  
Zita Márkus ◽  
Gábor Braunitzer ◽  
Antal Berényi ◽  
Marek Wypych ◽  
...  
Keyword(s):  
Visual Information ◽  
Frequency Tuning ◽  
Temporal Frequency ◽  
Neuronal Population ◽  
Neuronal Responses ◽  
Temporal Properties ◽  
Visual Receptive Field ◽  
Detailed Statistical Analysis ◽  
Spatio Temporal ◽  
Visual Properties

AbstractOur study compares the spatio-temporal visual receptive field properties of different subcortical stages of the ascending tectofugal visual system. Extracellular single-cell recordings were performed in the superficial (SCs) and intermediate (SCi) layers of the superior colliculus (SC), the suprageniculate nucleus (Sg) of the posterior thalamus and the caudate nucleus (CN) of halothane-anesthetized cats. Neuronal responses to drifting gratings of various spatial and temporal frequencies were recorded. The neurons of each structure responded optimally to low spatial and high temporal frequencies and displayed narrow spatial and temporal frequency tuning. The detailed statistical analysis revealed that according to its stimulus preferences the SCs has markedly different spatio-temporal properties from the homogeneous group formed by the SCi, Sg and CN. The SCs neurons preferred higher spatial and lower temporal frequencies and had broader spatial tuning than the other structures. In contrast to the SCs the visually active SCi, as well as the Sg and the CN neurons possessed consequently similar spatio-temporal preferences. These data support our hypothesis that the visually active SCi, Sg and CN neurons form a homogeneous neuronal population given a similar spatio-temporal frequency preference and a common function in processing of dynamic visual information.

Spatio-temporal properties of oculomotor activation by multiple, simultaneous peripheral stimuli

2021 ◽  
Vol 188 ◽  
pp. 251-261
Author(s):  
John Christie ◽  
Matthew D. Hilchey ◽  
Raymond M. Klein
Keyword(s):  
Temporal Properties ◽  
Spatio Temporal

Spatio-temporal properties of the pattern of evoked phantom sensations in a left index amputee patient.

1997 ◽  
Vol 111 (5) ◽  
pp. 867-872 ◽  
Author(s):  
Salvatore Aglioti ◽  
Nicola Smania ◽  
Andrea Atzei ◽  
Giovanni Berlucchi
Keyword(s):  
Temporal Properties ◽  
Spatio Temporal

scholarly journals Reduced influence of perceptual context in schizophrenia: behavioral and neurophysiological evidence

2019 ◽  
pp. 1-9 ◽  
Author(s):  
Victor J. Pokorny ◽  
Timothy J. Lano ◽  
Michael-Paul Schallmo ◽  
Cheryl A. Olman ◽  
Scott R. Sponheim
Keyword(s):  
Event Related Potentials ◽  
Contour Integration ◽  
Contour Detection ◽  
Group Differences ◽  
Neural Responses ◽  
Contour Perception ◽  
Accurate Perception ◽  
Visual Contour ◽  
Related Potentials ◽  
Intermediate Performance

Abstract Background Accurate perception of visual contours is essential for seeing and differentiating objects in the environment. Both the ability to detect visual contours and the influence of perceptual context created by surrounding stimuli are diminished in people with schizophrenia (SCZ). The central aim of the present study was to better understand the biological underpinnings of impaired contour integration and weakened effects of perceptual context. Additionally, we sought to determine whether visual perceptual abnormalities reflect genetic factors in SCZ and are present in other severe mental disorders. Methods We examined behavioral data and event-related potentials (ERPs) collected during the perception of simple linear contours embedded in similar background stimuli in 27 patients with SCZ, 23 patients with bipolar disorder (BP), 23 first-degree relatives of SCZ, and 37 controls. Results SCZ exhibited impaired visual contour detection while BP exhibited intermediate performance. The orientation of neighboring stimuli (i.e. flankers) relative to the contour modulated perception across all groups, but SCZ exhibited weakened suppression by the perceptual context created by flankers. Late visual (occipital P2) and cognitive (centroparietal P3) neural responses showed group differences and flanker orientation effects, unlike earlier ERPs (occipital P1 and N1). Moreover, behavioral effects of flanker context on contour perception were correlated with modulation in P2 & P3 amplitudes. Conclusion In addition to replicating and extending findings of abnormal contour integration and visual context modulation in SCZ, we provide novel evidence that the abnormal use of perceptual context is associated with higher-order sensory and cognitive processes.

scholarly journals Neural responses to peer rejection in anxious adolescents

2011 ◽  
Vol 36 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Jennifer Y. F. Lau ◽  
Amanda E. Guyer ◽  
Erin B. Tone ◽  
Jessica Jenness ◽  
Jessica M. Parrish ◽  
...  
Keyword(s):  
Negative Emotion ◽  
Peer Rejection ◽  
Group Differences ◽  
Neural Responses ◽  
Subjective Ratings ◽  
Social Feedback ◽  
Cognitive Differences ◽  
Adolescent Anxiety ◽  
Neuroimaging Data ◽  
Hippocampal Complex

Peer rejection powerfully predicts adolescent anxiety. While cognitive differences influence anxious responses to social feedback, little is known about neural contributions. Twelve anxious and twelve age-, gender- and IQ-matched, psychiatrically healthy adolescents received “not interested” and “interested” feedback from unknown peers during a chat room task administered in a neuroimaging scanner. No group differences emerged in subjective ratings to peer feedback, but all participants reported more negative emotion at being rejected (than accepted) by peers to whom they had assigned high-desirability ratings. Further highlighting the salience of such feedback, all adolescents, independently of anxiety levels, manifested elevated responses in the amygdala-hippocampal complex bilaterally, during the anticipation of feedback. However, anxious adolescents differed from healthy adolescents in their patterns of persistent amygdala-hippocampal activation following rejection. These data carry interesting implications for using neuroimaging data to inform psychotherapeutic approaches to social anxiety.

Exploiting Spatio-Temporal Properties of I/Q Signal Data using 3D Convolution for RF Transmitter Identification

2021 ◽  
pp. 1-1 ◽  
Author(s):  
Muthukumaran Ramasubramanian ◽  
Chaity Banerjee ◽  
Debashri Roy ◽  
Eduardo Pasiliao ◽  
Tathagata Mukherjee
Keyword(s):  
Temporal Properties ◽  
Rf Transmitter ◽  
Spatio Temporal

Exploring Intra-Urban Travel Mobility using Large-Scale Taxi Global Positioning System Trajectories

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Haixiao Wang ◽  
Fang Liu ◽  
Jinjun Tang
Keyword(s):  
Large Scale ◽  
Human Mobility ◽  
Central Business District ◽  
Operation Efficiency ◽  
Temporal Properties ◽  
Harbin City ◽  
Residential District ◽  
Spatio Temporal ◽  
Gps Devices ◽  
Business District

Using taxi GPS trajectories data is of very importance to explore Spatio-temporal features of human mobility in transportation designing and planning. The data were collected from taxi GPS devices in Harbin city during a week. The taxi trips are extracted from GPS data, and travel distance and time in occupied and vacant states are firstly used to investigate the human mobility. Then, the urban area is divided into 400 grids. Furthermore, travelling network corresponding to taxi trips are designed to further examine the dynamics of mobility, in which the grid are considered as nodes and edge weights are defined as total number of trips among nodes. We observe some basic statistical features of network: degree, edge weights, clustering coefficients and network structure entropy. We also use the correlation between strength and degree to analyze the significance of nodes. Based on network analysis, we select two grids, a central business district and a residential district with high degree and strength, to study the spatial and temporal properties of trips that start from and end at these two grids. Finally, the correlation between trip volume and operation efficiency is explored and we find that hourly trip volume express negative correlation with operation efficiency.

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