Taste and Smell Functions in Long-term Survivors after Childhood Medulloblastoma/CNS-PNET

Purpose Our aim was to investigate taste and smell functions in survivors, with a minimum of 2 years follow-up time, after treatment of childhood medulloblastoma/CNS-PNET. Methods This cross-sectional study included 40 survivors treated ≤ 20 years of age. Taste strips with four concentrations of sweet, sour, salt, and bitter were used to assess taste function in all participants. Score from 0-16; ≥ 9 normogeusia, < 9 hypogeusia, and complete ageusia which equals no sensation. No sensation of a specific taste quality equals ageusia of that quality. Thirty-two participants conducted smell testing using three subtests of Sniffin’ sticks; threshold, discrimination, and identification. Together they yield a TDI-score from 1-48; functional anosmia ≤ 16.00, hyposmia >16.00 - < 30.75, normosmia ≥ 30.75 - < 41.50, and ≥ 41.50 super smeller. Results were compared with normative data. Survivors subjectively rated their taste and smell functions using a numerical rating scale (NRS) score 0-10. Results Forty survivors with a mean follow-up of 20.5 years, 13 (32.5 %) were diagnosed with hypogeusia, nine (22.5 %) of these being ageusic of one or more taste qualities. Seventeen (53 %) of 32 participants were diagnosed with hyposmia. Comparing survivors with hyposmia to those with normosmia, a significant difference (p<0.05) was found in TDI-score and in all the subtests. The mean NRS score of subjective ratings of functions were high.Conclusion Our study showed impaired taste and smell functions in long-term survivors of childhood MB/CNS-PNET using objective measurements. However, subjective ratings did not reflect objective findings.

Influence of game format and team strategy on physical and perceptual intensity in soccer small-sided games

The aim of the study was to compare internal and external load responses of different small-sided games, using balanced (5v5 Possession and small-sided games formats) and unbalanced (6v4) teams. Ten elite youth male soccer players were monitored at the start of the in-season period using global positioning system, heart rate and subjective ratings of intensity. Results showed higher physiological stress (>90% HRmax) in Possession and small-sided games formats when compared to the unbalanced teams (ES = 1.3–2.3). Total and high-intensity distance in small-sided games (28 ± 25 m) and Possession (67 ± 35 m) were greater compared to teams of 6 and 4 in the unbalanced scenario. Small-sided games format and team with six players had higher proportion of distance running at sub-maximal velocities (0–5.8 m/s2). Small-sided games format and team with four players saw greater mean acceleration effort (mean acceleration intensity in small-sided games 1.91 ± 0.27 vs. Possession 1.80 ± 0.20 m/s2, ES = 0.4 and Team 4 1.56 ± 0.24 vs. Team 6 1.44 ± .0.19 m/s2, ES = 1.3). Small-sided games format and team with 6 players had lower starting velocities prior to acceleration efforts (small-sided games 0.90 ± 0.08 and Team 6 1.11 ± 0.11 m/s2, ES = 1.5 and ES = 1.8), while velocity at the end of each acceleration effort was greater in the Possession format and Team 4 compared to small-sided games and Team 6 (Possession 3.54 ± 0.23 m/s2 and Team 4 3.13 ± 0.22 m/s2) compared to the small-sided games format (ES = 0.1) and the team with six players (ES = 2.3). These data demonstrate that using unbalanced teams can provide an additional form of training prescription to facilitate player specific training within a squad environment by providing different internal and external training responses within a combined drill.

Recognition of Affective Faces of Different Age Groups

It has been found that valence and arousal are the core affect dimensions in emotional structure. In this study, we hypothesized that there might be differences between different age groups in emotional structure using six facial expression stimuli (angry, disgusted, fearful, neutral, happy, and sad) of three age groups (young, middle-aged, and old). Unlike previous studies asking participants to rate subjective ratings or similarities between stimuli, participants in this study were required to determine whether stimulus pairs were the same or different emotions and reaction time and accuracy were measured for further analyses. We assumed that it would be harder when the stimulus pair is similar whereas it would be easier when the pair is different. The results showed that for the same emotion pair condition, the sad-sad pair had the lowest accuracy and the longest reaction time, while the happiness-happiness pair had the highest accuracy and the shortest reaction time. For the different emotion pairs, angry-disgusted and disgusted-sad was the lowest accuracy and the longest reaction time. For age of the stimuli effect, responses to the old faces had the lowest accuracy and the longest reaction time. The results suggest that identification of emotional stimuli might be affected by emotion category and age. Further study may need to recruit various age groups, because participants in the current study were mostly young adults.

User Behavioral Intentions toward a Scooter-Sharing Service: An Empirical Study

This paper proposes an innovative shared scooter service whereby scooter owners can authorize the rental of their scooters to others through a mobile service platform. It constitutes a public short-distance mobility service for travelers and increases the efficient utilization of each private scooter. The study examines the adoption of scooter-sharing services by travelers and adapts the unified theory of acceptance and use of technology, attitude, and user experience (UX) to investigate the factors that may influence traveler acceptance of scooter-sharing services. The data were collected from Taiwanese travelers who used the shared scooters provided in this study and completed pre- and post-use subjective ratings of the scooter-sharing service (n = 99), analyzed using a hierarchical multiple regression analysis. The results indicate that the model constructs of habit, social influence, and environmental protections may positively affect users’ behavioral intentions toward shared scooters, while performance expectancy and effort expectancy may negatively affect intention to use. Attitudes and UX had no direct effect on intention to use. In light of the findings, recommendations for improving the design of scooter-sharing services, implications for service providers, and a reference basis for the development of future shared micro-mobility services are provided.

Ethyl Loflazepate as a Treatment for Patients with Idiopathic and Psychogenic Taste Disorder

Ethyl loflazepate (EL) is a benzodiazepine derivative that has been reported to activate the gustatory cortex. Our department routinely uses EL as a first-line treatment for idiopathic and psychogenic taste disorders, although little has been reported in the literature with respect to patient outcomes, so we conducted a retrospective study examining its safety and efficacy. Between 2008 and 2020, 49 patients (14 males and 35 females; mean age, 62.1 years) were diagnosed with taste disorders and received EL as their only treatment for &amp;gt;14 days. Severity of taste disorder was evaluated using the paper disc method by Sakai et al [7], and treatment efficacy was evaluated using the Visual Analogue Scale, wherein patients gave subjective ratings for their symptoms (reductions by &amp;gt;50% after administration of EL for 4 weeks were defined as mprovements). Results showed that the improvement rates for patients with idiopathic and psychogenic taste disorders were 55% and 70%, respectively. Additionally, the majority (78%) improved within 2 weeks, and side effects were mild (seven cases of sleepiness and one case of dizziness). We conclude that EL is an appropriate first-line medication for patients with idiopathic and psychogenic taste disorders.

The surgical safety checklist: a quantitative study on attitudes and barriers among gynecological surgery teams

Background Implementation of the surgical safety checklist (SSC) plays a significant role in improving surgical patient safety, but levels of compliance to a SSC implementation by surgical team members vary significantly. We aimed to investigate the factors affecting satisfaction levels of gynecologists, anesthesiologists, and operating room registered nurses (OR-RNs) with SSC implementation. Methods We conducted a survey based on 267 questionnaires completed by 85 gynecologists from 14 gynecological surgery teams, 86 anesthesiologists, and 96 OR-RNs at a hospital in China from March 3 to March 16, 2020. The self-reported questionnaire was used to collect respondent’s demographic information, levels of satisfaction with overall implementation of the SSC and its implementation in each of the three phases of a surgery, namely sign-in, time-out, and sign-out, and reasons for not giving a satisfaction score of 10 to its implementation in all phases. Results The subjective ratings regarding the overall implementation of the SSC between the surgical team members were different significantly. “Too many operations to check” was the primary factor causing gynecologists and anesthesiologists not to assign a score of 10 to sign-in implementation. The OR-RNs gave the lowest score to time-out implementation and 82 (85.42%) did not assign a score of 10 to it. “Surgeon is eager to start for surgery” was recognized as a major factor ranking first by OR-RNs and ranking second by anesthesiologists, and 57 (69.51%) OR-RNs chose “Too many operations to check” as the reason for not giving a score of 10 to time-out implementation. “No one initiates” and “Surgeon is not present for ‘sign out’” were commonly cited as the reasons for not assigning a score of 10 to sign-out implementation. Conclusion Factors affecting satisfaction with SSC implementation were various. These factors might be essentially related to heavy workloads and lack of ability about SSC implementation. It is advisable to reduce surgical team members’ excessive workloads and enhance their understanding of importance of SSC implementation, thereby improving surgical team members’ satisfaction with SSC implementation and facilitating compliance of SSC completion.

Mapping Directional Mid-Air Unistroke Gestures to Interaction Commands: A User Elicitation and Evaluation Study

A stroke is the basic limb movement that both humans and animals naturally and repetitiously perform. Having been introduced into gestural interaction, mid-air stroke gestures saw a wide application range and quite intuitive use. In this paper, we present an approach for building command-to-gesture mapping that exploits the semantic association between interactive commands and the directions of mid-air unistroke gestures. Directional unistroke gestures make use of the symmetry of the semantics of commands, which makes a more systematic gesture set for users’ cognition and reduces the number of gestures users need to learn. However, the learnability of the directional unistroke gestures is varying with different commands. Through a user elicitation study, a gesture set containing eight directional mid-air unistroke gestures was selected by subjective ratings of the direction in respect to its association degree with the corresponding command. We evaluated this gesture set in a following study to investigate the learnability issue, and the directional mid-air unistroke gestures and user-preferred freehand gestures were compared. Our findings can offer preliminary evidence that “return”, “save”, “turn-off” and “mute” are the interaction commands more applicable to using directional mid-air unistrokes, which may have implication for the design of mid-air gestures in human–computer interaction.

Relationship Between Subjective Ratings of Answers and Behavioral and Autonomic Nervous Activities During Creative Problem-Solving via Online Conversation

Creative problem solving has been important for the advent of new technologies. In this study, we hypothesized that subjective ratings of answers should be useful for evaluating the answer quality in creative problem solving. To test this hypothesis and extract objective indicators of the subjective ratings of answers, we evaluated the relationship between subjective ratings of task performance and behavioral and autonomic nervous activities during a creative problem-solving task performed via online conversation. The task involved an answerer and a supporter, and in the experiment, each pair performed 10 trials. The trials were categorized as highly or lowly rated according to the answerer’s confidence in the answer. The task performance and behavioral and autonomic nervous activities were then compared between these categories of trials. Behavioral activity was evaluated via movements and speech activities, while for autonomic nervous activity, sympathetic nervous activity (SNA) was evaluated via skin conductance. The task performance was significantly better in the highly rated trials, whereas there were no significant differences in the behavioral activities between the highly and lowly rated trials. Moreover, in the highly rated trials, the skin conductance of the answerer was significantly high, whereas that of the supporter was significantly low. The results support the hypothesis and suggest that contrasting differences in SNA between an answerer and a supporter are indicators of the subjective ratings of answers in creative problem solving.

P096 Subjective ratings of medication strength of lemborexant over 6 months in subjects with moderate or severe insomnia

Introduction In Study 303 (SUNRISE-2), significantly more subjects reported a positive effect of lemborexant (LEM), a dual orexin receptor antagonist, versus placebo (PBO) on their sleep at 1mo, 3mo and 6mo, as assessed by items 1–3 of the Patient Global Impression–Insomnia (PGI-I). LEM-treated subjects also reported larger and statistically significant decreases in the Insomnia Severity Index (ISI) versus PBO. This analysis examined potential LEM tolerance via patient-reported ratings of medication strength on PGI-I item 4 in subjects with moderate/severe insomnia. Methods In this 12mo double-blind, PBO-controlled (first 6mo), phase 3 study, subjects ≥18y with insomnia disorder and ISI scores ≥15 were randomized to PBO (n=318) or LEM (5mg, [LEM5], n=316; 10mg, [LEM10], n=315). The ISI and PGI-I were administered at 1mo, 3mo and 6mo. Results The percentage of subjects with moderate (ISI=15–21; n=692) or severe (ISI=22–28; n=223) insomnia at baseline who rated LEM as “just right” increased from 1mo (moderate: LEM5=46.4%; LEM10=43.3%; PBO=31.3%; severe: LEM5=35.8%; LEM10=40.6%; PBO=15.0%) to 6mo (moderate: LEM5=56.5%; LEM10=53.9%; PBO=39.7%; severe: LEM5= 54.8%; LEM10=55.4%; PBO=21.6%). Ratings of “too weak” decreased over 6 months in both ISI severity groups. PBO group ratings of “too weak” always exceeded the LEM groups by &gt;15%. Ratings of “too strong” were low and stable over time. Conclusions Findings suggest that LEM tolerance does not occur over 6mo with either LEM dose since patient perceptions of LEM treatment being “too weak” did not increase over the study period. These data support the persistent efficacy of long-term LEM treatment for chronic insomnia.

Mental heartbeat tracking and rating of emotional pictures are not related

Our aim was to conceptually replicate the findings of previous empirical studies showing that people with higher cardiac interoceptive accuracy experience more intense emotions. Apart of the mental heartbeat tracking task of Schandry, Hungarian (n = 46, 76.0% female, mean age 22.28 ± 2.228) and Norwegian (n = 50, 60.0% female, mean age 24.66 ± 3.048) participants rated the arousal and valence evoked by positive, neutral and negative pictures. Multivariate repeated analysis of variance (applying both frequentist and Bayesian approaches) did not reveal any connection between heartbeat perception scores and the subjective ratings (i.e., arousal and valence) of the pictures in any of the two groups. The lack of the expected association between cardioceptive accuracy and arousal might partly be explained by the methodological differences between previous studies and this one; for example, we did not split or preselected the sample based on the performance on the Schandry task and applied a relatively strict instruction (i.e., by encouraging to count felt heartbeats only, and to report zero if no sensations were detected).