Normal atrial natriuretic peptide release after acute and chronic stimuli in hypophysectomized rats

To test the hypothesis that the pituitary gland has a role in modulating the release of atrial natriuretic peptide (ANP) from atrial myocytes, we applied different stimuli of both acute and chronic nature to rats 8-10 days after hypophysectomy (Hypx). Acute rapid cardiac pacing at a rate of 500 beats/min in anesthetized rats caused a marked increase in plasma levels of ANP (from 76 +/- 7 to 237 +/- 60 pg/ml, P less than 0.05) despite a marked decrease of blood pressure. This response was similar to that of paced control rats, but because the basal levels were lower in Hypx rats, the relative increase in ANP was larger in the experimental group. Studies were also done in a chronic model of high-output congestive heart failure produced by an aortocaval fistula in hydrocortisone-supplemented rats. Although these rats had low blood pressure 2-3 days after surgery, there were marked increases in right atrial pressures associated with high plasma levels of ANP (194 +/- 24 pg/ml) that were not significantly different from controls (221 +/- 26 pg/ml, P greater than 0.05). These results indicate that the role of the pituitary in ANP release is indirect, and no specific hypophyseal factor is required for this response. Hemodynamic parameters are the important determinants of ANP secretion, even in hypophysectomized rats.

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High Plasma Levels of N-Terminal Pro-Atrial Natriuretic Peptide Associated With Low Anxiety in Severe Heart Failure

Psychosomatic Medicine ◽

10.1097/01.psy.0000073870.93003.c4 ◽

2003 ◽

Vol 65 (4) ◽

pp. 517-522 ◽

Cited By ~ 39

Author(s):

Christoph Herrmann-Lingen ◽

Lutz Binder ◽

Michael Klinge ◽

Julia Sander ◽

Wiebke Schenker ◽

...

Keyword(s):

Heart Failure ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Plasma Levels ◽

Severe Heart Failure ◽

High Plasma ◽

Atrial Natriuretic

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Paradoxical inhibition of atrial natriuretic peptide release during pacing-induced hypotension

Clinical Science ◽

10.1042/cs0730459 ◽

1987 ◽

Vol 73 (5) ◽

pp. 459-462 ◽

Cited By ~ 8

Author(s):

P. Erne ◽

A. E. G. Raine ◽

E. Burgisser ◽

E. Gradel ◽

F. Burkart ◽

...

Keyword(s):

Blood Pressure ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Plasma Catecholamines ◽

Cardiac Pacing ◽

Systemic Blood Pressure ◽

Atrial Pressure ◽

Ventricular Pacing ◽

Peptide Release ◽

Atrial Natriuretic

1. To determine the influence of loss of atrioventricular synchrony on release of atrial natriuretic peptide (ANP), plasma ANP concentrations were measured by radioreceptor assay in 16 patients during sequential and ventricular cardiac pacing at normal heart rates. 2. Ventricular pacing induced an increase in plasma ANP concentrations (means ± SEM) from 44 ± 3 to 104 ± 4 pmol/l (P < 0.01) in 11 patients in whom systemic blood pressure was maintained. 3. In contrast, when ventricular pacing was associated with a fall in blood pressure (five patients), ANP levels (means ± SEM) fell from 68 ± 6 to 14 ± 4 pmol/l (n = 5, P < 0.05) within 5 min, despite an increase in atrial pressure. Plasma catecholamines also rose significantly in these latter patients. 4. We conclude that when loss of atrioventricular synchrony is well tolerated haemodynamically, cardiac release of ANP is increased in keeping with elevation in atrial pressure. However, the fall in plasma ANP concentration observed when ventricular pacing produces a fall in blood pressure suggests that in addition to atrial pressure, ANP release may be influenced by negative feedback mechanisms, possibly involving the baroreflex and autonomic nervous system.

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Elevated angiotensin II and vasopressin in primary hyperparathyroidism. Angiotensin II infusion studies before and after removal of the parathyroid adenoma

Acta Endocrinologica ◽

10.1530/acta.0.1200362 ◽

1989 ◽

Vol 120 (3) ◽

pp. 362-368 ◽

Cited By ~ 9

Author(s):

B. Jespersen ◽

E. B. Pedersen ◽

P. Charles ◽

H. Danielsen ◽

H. Juhl

Keyword(s):

Blood Pressure ◽

Angiotensin Ii ◽

Primary Hyperparathyroidism ◽

Atrial Natriuretic Peptide ◽

Creatinine Clearance ◽

Natriuretic Peptide ◽

Arginine Vasopressin ◽

Plasma Levels ◽

Before And After ◽

Atrial Natriuretic

Abstract. In order to evaluate the role of calcium metabolism in blood pressure regulation, 15 patients with primary hyperparathyroidism and 9 healthy control subjects were studied before and during angiotensin II infusion. The patients were re-investigated 2–5 months after removal of the parathyroid adenoma. Blood pressure, plasma levels of angiotensin II, aldosterone, arginine vasopressin, and atrial natriuretic peptide, and creatinine clearance were determined. Blood pressure and the blood pressure response to angiotensin II infusion were both the same before and after the operation. Angiotensin II and arginine vasopressin during basal conditions were significantly higher before than after the operation (angiotensin II: 17 (median) to 10 pmol/l, P < 0.02; arginine vasopressin: 2.9 to 1.9 pmol/l, P < 0.01), whereas aldosterone, atrial natriuretic peptide, and creatinine clearance were unchanged. During angiotensin II infusion, aldosterone, arginine vasopressin, and atrial natriuretic peptide increased to approximately the same levels before and after the operation. Blood pressure was not correlated to any of the hormones measured. Thus, patients with primary hyperparathyroidism have elevated plasma levels of angiotensin II and arginine vasopressin which may be compensatory phenomena counteracting volume depletion owing to a decreased renal concentrating ability induced by hypercalcemia, and owing to PTH-induced inhibition of renal sodium reabsorption.

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Effects of Moxibustion on Blood Pressure and Renal Function in Spontaneously Hypertensive Rats

The American Journal of Chinese Medicine ◽

10.1142/s0192415x97000056 ◽

1997 ◽

Vol 25 (01) ◽

pp. 21-26 ◽

Cited By ~ 11

Author(s):

Ho Sub Lee ◽

Yun Cho Yu ◽

Seong Tae Kim ◽

Kyung Sik Kim

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Atrial Natriuretic Peptide ◽

Systolic Blood Pressure ◽

Natriuretic Peptide ◽

Plasma Levels ◽

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Atrial Natriuretic

The aim of this study was to investigate the effects of moxibustion at the meridian points BL-15 (Xin-shu) and BL-27 (Xiao-chang-shu) on renal function, systolic blood pressure, plasma levels of renin activity, aldosterone and atrial natriuretic peptide in spontaneously hypertensive rats. The results showed that urine volume increased significantly after moxibustion at the meridian points BL-15, but decreased at BL-27. Urinary excretion of Na + decreased after moxibustion at the meridian points BL-15 and BL-27. Systolic blood pressure decreased after moxibustion at the meridian point BL-15. No effect was observed at BL-27. Plasma levels of aldosterone and renin activity increased significantly, but the levels of atrial natriuretic peptide decreased significantly after moxibustion at BL-15. Plasma levels of aldosterone and atrial natriuretic peptide increased significantly after moxibustion at the meridian points BL-27. These results suggest that the meridian points BL-15 and BL-27 are related to the regulation of renal function and the secretion of hormone with body fluid metabolism.

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