Faculty Opinions recommendation of GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.

To evaluate the role of atrial natriuretic peptide (ANP) in exercise-related cardiovascular and hormonal adjustments in hypobaric conditions, 14 young athletes performed a maximal ergometer test in a hypobaric chamber adjusted to simulate the altitudes of sea level and 3,000 m. Plasma immunoreactive ANP levels rose from 5.89 to 35.1 pmol/l at sea level and rose significantly less (P less than 0.05), from 5.36 to 22.3 pmol/l, at simulated 3,000 m. Plasma immunoreactive amino-terminal peptide of proANP (NT-proANP) levels increased to the same extent at sea level and at simulated 3,000 m (from 240 to 481 pmol/l and from 257 to 539 pmol/l, respectively). Plasma immunoreactive aldosterone increased significantly less at simulated 3,000 m (P less than 0.05), but the changes in plasma renin were similar in both conditions. Plasma immunoreactive endothelin-1 and serum erythropoietin levels remained unchanged. In conclusion, we found a blunted ANP response to maximal exercise of ANP in acute hypobaric exposure compared with that in normobaric conditions, but no significant difference in the NT-proANP responses between the two conditions. The divergence may be due to stimulation of the elimination mechanism of ANP.

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Renin and atrial natriuretic peptide restriction fragment length polymorphisms: association with ethnicity and blood pressure

Journal of Hypertension ◽

10.1097/00004872-199111000-00003 ◽

1991 ◽

Vol 9 (11) ◽

pp. 993-996 ◽

Cited By ~ 59

Author(s):

Jacqueline Barley ◽

Nicholas D. Carter ◽

J Kennedy Cruickshank ◽

Stephen Jeffery ◽

Alberto Smith ◽

...

Keyword(s):

Blood Pressure ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Restriction Fragment ◽

Fragment Length ◽

Restriction Fragment Length Polymorphisms ◽

Length Polymorphisms ◽

Restriction Fragment Length ◽

Atrial Natriuretic

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Atrial natriuretic peptide and adaptation of sodium urinary excretion in patients with chronic renal failure

Clinical Science ◽

10.1042/cs0750243 ◽

1988 ◽

Vol 75 (3) ◽

pp. 243-249 ◽

Cited By ~ 10

Author(s):

Stanislas Czekalski ◽

Catherine Michel ◽

Jean-Claude Dussaule ◽

Philippe Touraine ◽

Francoise Mignon ◽

...

Keyword(s):

Blood Pressure ◽

Renal Failure ◽

Chronic Renal Failure ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Sodium Excretion ◽

Mean Blood Pressure ◽

Group Iii ◽

Sodium Load ◽

Atrial Natriuretic

1. In order to examine the potential role of endogenous atrial natriuretic peptide (ANP) in modulating the increased sodium excretion per nephron in chronic renal failure, we studied healthy subjects with normal renal function (group I) and patients with moderate (group II) or severe chronic renal failure (group III) before, during and after administration of an intravenous sodium load. All subjects had been on a controlled diet containing 120 mmol of sodium per day for 5 days before the study. 2. Under basal conditions, plasma ANP and fractional excretion of sodium (FENa) were highest in group III. Both parameters increased in response to the sodium load in the three groups studied (P < 0.001). Changes with time differed from group to group (P < 0.05), the more marked response for both parameters being observed in group III. After adjustment with respect to plasma ANP (analysis of covariance), FENa was no longer modified in response to the sodium load, whereas adjustment of FENa with respect to mean blood pressure was without consequence on the significance of its change with time. This demonstrates that plasma ANP, but not mean blood pressure, represents the main factor producing variation in FENa during and after the sodium load. 3. These results suggest an important role for plasma ANP in promoting adaptation of short-term sodium excretion in response to an acute sodium load in patients with chronic renal failure who ingest a normal sodium intake.

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