Effect of endurance training on beta-adrenergic system in three different skeletal muscles

1993 ◽  
Vol 74 (4) ◽  
pp. 1641-1646 ◽  
Author(s):  
G. Plourde ◽  
S. Rousseau-Migneron ◽  
A. Nadeau
Keyword(s):  
Adenylate Cyclase ◽  
Adrenergic Receptor ◽  
Skeletal Muscles ◽  
Vastus Lateralis ◽  
Treadmill Running ◽  
Adrenergic System ◽  
Vastus Lateralis Muscle ◽  
Receptor Density ◽  
Beta Adrenergic ◽  
Lateralis Muscle

The beta-adrenergic receptor density (Bmax) and adenylate cyclase (AC) activity in the soleus muscle and deep red and white superficial portions of the vastus lateralis muscle were evaluated in a group of rats submitted to a progressive 10-wk treadmill running program (n = 19) and compared with a group of rats kept sedentary (n = 17) during the same period of time.(ABSTRACT TRUNCATED AT 250 WORDS)

Decreased beta-adrenergic receptor density in mononuclear leukocytes from thyroidectomized patients

1983 ◽  
Vol 103 (1) ◽  
pp. 40-45 ◽  
Author(s):  
G. Cognini ◽  
L. Piantanelli ◽  
E. Paolinelli ◽  
P. Orlandoni ◽  
A. Pellegrini ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Surgical Stress ◽  
Serum Levels ◽  
Mononuclear Leukocytes ◽  
Adrenergic System ◽  
Receptor Density ◽  
Beta Adrenergic Receptor ◽  
Peripheral Blood Mononuclear ◽  
Beta Adrenergic ◽  
Before And After

Abstract. Beta-adrenergic receptor characteristics were investigated in peripheral blood mononuclear leukocytes taken from patients before and after partial thyroidectomy. In order to discriminate the effect of surgical stress per se from that of thyroidectomy, the analysis was also performed on patients before and after cholecystectomy. Receptor characteristics were determined by using dihydroalprenolol as ligand in direct equilibrium binding experiments. The binding affinity showed no changes either when two different surgical treatments were compared or when the same patient was analysed before and after the operation. On the contrary, a significant decrease in receptor density was found in thyroidectomized patients when compared pre- and post-operatively. This fall in receptor number seems to be linked with thyroid function since no statistically significant changes were observed in cholecystectomized patients in relation to surgical operation. This view is further supported by data on T3 serum levels, which show a significant fall after thyroidectomy but no statistically significant modifications after cholecystectomy. It is concluded that betaadrenoceptor modulation plays an important role in the relationship between thyroid and beta-adrenergic system.

Beta-receptors and adenylate cyclase: comparison of nonischemic, ischemic, and postmortem tissue

1990 ◽  
Vol 258 (1) ◽  
pp. H140-H144 ◽  
Author(s):  
D. E. Vatner ◽  
M. A. Young ◽  
D. R. Knight ◽  
S. F. Vatner
Keyword(s):  
Adenylate Cyclase ◽  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Striking Similarity ◽  
Receptor Density ◽  
Beta Adrenergic Receptors ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic

We compared the effects of myocardial ischemia and postmortem changes on beta-adrenergic receptors and their coupling to adenylate cyclase activity. The effects of 1 h of left circumflex coronary artery occlusion were examined in eight conscious calves, which were then anesthetized with pentobarbital sodium, and the left ventricle was divided into nonischemic and ischemic regions. A crude membrane fraction was prepared from each region and from the nonischemic tissue 1 h postmortem. beta-Adrenergic receptor density increased (152 +/- 55%) and decreases in basal (-21 +/- 6.1%), isoproterenol-stimulated (-25 +/- 8.0%), 5'-guanylylimidodiphosphate [Gpp(NH)p]-stimulated (-17 +/- 5.8%), fluoride-stimulated (-26 +/- 5.8%), and forskolin-stimulated (-31 +/- 8.4%) adenylate cyclase activities were observed in the ischemic myocardium compared with nonischemic myocardium. Similarly, in postmortem samples, beta-adrenergic receptor density rose 58 +/- 16%, whereas decreases in basal (-48 +/- 8.7%), isoproterenol-stimulated (-61 +/- 7.8%), Gpp(NH)p-stimulated (-58 +/- 7.0%), fluoride-stimulated (-64 +/- 6.1%), and forskolin-stimulated (-52 +/- 6.2%) adenylate cyclase activities were observed. Agonist-binding competition curves with isoproterenol were shifted, indicating that beta-adrenergic receptors were binding agonists with low affinity in both the ischemic and postmortem myocardium. The marked, but directionally opposite, changes in receptor density and adenylate cyclase that occur postmortem indicate the importance of prompt processing of tissues. The striking similarity in response of beta-adrenergic receptor agonist and antagonist binding and adenylate cyclase activity in ischemic and postmortem tissue raises the speculation that similar mechanisms may operate under both conditions.

Glucocorticoids modulate beta-adrenoceptor subtypes and adenylate cyclase in brown fat

1988 ◽  
Vol 255 (2) ◽  
pp. E153-E158 ◽  
Author(s):  
P. J. Scarpace ◽  
L. A. Baresi ◽  
J. E. Morley
Keyword(s):  
Adenylate Cyclase ◽  
Adrenergic Receptor ◽  
Weight Maintenance ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Receptor Subtype ◽  
Receptor Density ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Brown Adipose

Thermogenesis in brown adipose tissue (BAT) serves as a regulator of body temperature and weight maintenance. Thermogenesis can be stimulated by catecholamine activation of adenylate cyclase through the beta-adrenergic receptor. Glucocorticoids potentiate the action of catecholamines in some tissues by increasing the expression of beta-adrenergic receptors. Paradoxically, glucocorticoids suppress and adrenalectomy enhances BAT thermogenesis. To further study the reasons for this discrepancy, we assessed the effects of methylprednisolone administration, adrenalectomy, and adrenalectomy with corticosterone replacement on adenylate cyclase activity in BAT and on beta-adrenergic receptor density in lungs and BAT of rats. In lungs, the density of the beta 2-adrenergic receptor subtype increases after methylprednisolone administration and decreases after adrenalectomy. There was no change in BAT receptor density, but isoproterenol-, NaF-, and forskolin-stimulated adenylate cyclase activity was reduced by 20–35% after methylprednisolone treatment. There was a two- to threefold increase in adenylate cyclase activity after adrenalectomy, which was reversed by corticosterone administration. These data suggest that one mechanism by which glucocorticoids regulate BAT thermogenesis is by modulating the beta-adrenergic pathway at the level of adenylate cyclase activation.

Ayurvedic management of Myositis Ossificans of Vastus Lateralis Muscle (Urusthamba) - A Case Study

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Vishnu Mohan ◽  
Gopikrishna BJ ◽  
Avnish Pathak ◽  
Mahesh Kumar ES ◽  
Duradundi G
Keyword(s):  
Heterotopic Ossification ◽  
Myositis Ossificans ◽  
Vastus Lateralis ◽  
Treatment Protocol ◽  
Vastus Lateralis Muscle ◽  
Satisfactory Treatment ◽  
Lateralis Muscle ◽  
Ayurvedic Treatment

Myositis ossificansis characterized by heterotopic ossification (calcification) of muscle of various etiologies. It is most commonly affected in the quadriceps of the thighs. There are many tools available for diagnosis of Myositis ossificans, but lack of satisfactory treatment. So the development of a treatment protocol for Myositis ossificans is the need of today`s era. In Ayurveda, the same can be understood as Urusthamba. The present paper discusses a case of Myositis ossificans of right vastus lateralis muscle and its Ayurvedic treatment.

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