scholarly journals Metaplasticity in human primary somatosensory cortex: effects on physiology and tactile perception

2016 ◽  
Vol 115 (5) ◽  
pp. 2681-2691 ◽  
Author(s):  
Christina B. Jones ◽  
Tea Lulic ◽  
Aaron Z. Bailey ◽  
Tanner N. Mackenzie ◽  
Yi Qun Mi ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Time Course ◽  
Primary Motor Cortex ◽  
Temporal Order Judgment ◽  
Intracortical Inhibition ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Median Nerve Stimulation ◽  
Pulse Ratio ◽  
Theta Burst

Theta-burst stimulation (TBS) over human primary motor cortex evokes plasticity and metaplasticity, the latter contributing to the homeostatic balance of excitation and inhibition. Our knowledge of TBS-induced effects on primary somatosensory cortex (SI) is limited, and it is unknown whether TBS induces metaplasticity within human SI. Sixteen right-handed participants (6 females, mean age 23 yr) received two TBS protocols [continuous TBS (cTBS) and intermittent TBS (iTBS)] delivered in six different combinations over SI in separate sessions. TBS protocols were delivered at 30 Hz and were as follows: a single cTBS protocol, a single iTBS protocol, cTBS followed by cTBS, iTBS followed by iTBS, cTBS followed by iTBS, and iTBS followed by cTBS. Measures included the amplitudes of the first and second somatosensory evoked potentials (SEPs) via median nerve stimulation, their paired-pulse ratio (PPR), and temporal order judgment (TOJ). Dependent measures were obtained before TBS and at 5, 25, 50, and 90 min following stimulation. Results indicate similar effects following cTBS and iTBS; increased amplitudes of the second SEP and PPR without amplitude changes to SEP 1, and impairments in TOJ. Metaplasticity was observed such that TOJ impairments following a single cTBS protocol were abolished following consecutive cTBS protocols. Additionally, consecutive iTBS protocols altered the time course of effects when compared with a single iTBS protocol. In conclusion, 30-Hz cTBS and iTBS protocols delivered in isolation induce effects consistent with a TBS-induced reduction in intracortical inhibition within SI. Furthermore, cTBS- and iTBS-induced metaplasticity appear to follow homeostatic and nonhomeostatic rules, respectively.

scholarly journals Persistent Elevation of Electrical Pain Threshold following Continuous Theta Burst Stimulation over Primary Somatosensory Cortex in Humans

2019 ◽  
Author(s):  
Nishant Rao ◽  
Yen-Ting Chen ◽  
Regan Ramirez ◽  
John Tran ◽  
Sheng Li ◽  
...  
Keyword(s):  
Young Adults ◽  
Somatosensory Cortex ◽  
Pain Threshold ◽  
Primary Motor Cortex ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation ◽  
Persistent Elevation

ABSTRACTBackgroundPrimary somatosensory cortex (S1) is involved in pain processing and thus its suppression using neuromodulatory techniques such as continuous theta burst stimulation (cTBS) might be a potential pain management strategy in patients with neuropathic pain. S1 cTBS is known to elevate pain threshold in young adults. However, the persistence of this effect is unknown.Objective/HypothesisWe hypothesized persistent elevation of pain threshold following cTBS over S1 in healthy, young adults.MethodsWe recruited ten subjects in a sham-controlled crossover design and recorded their electrical pain threshold (EPT) for 40 min following cTBS over S1. We assessed corticospinal excitability (CSE) to rule out the involvement of primary motor cortex due to spread of current.ResultscTBS over S1 elevated EPT without modulating CSE compared to sham stimulation. EPT was elevated for 40 min post-cTBS.ConclusionsS1 can be focally targeted using cTBS for a longer lasting pain relief in patients.

30 Hz Theta-burst Stimulation Over Primary Somatosensory Cortex Modulates Corticospinal Output to the Hand

2014 ◽  
Vol 7 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Mark F. Jacobs ◽  
Philemon Tsang ◽  
Kevin G.H. Lee ◽  
Michael J. Asmussen ◽  
Christopher M. Zapallow ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

scholarly journals Theta-Burst Stimulation-Induced Plasticity over Primary Somatosensory Cortex Changes Somatosensory Temporal Discrimination in Healthy Humans

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32979 ◽  
Author(s):  
Antonella Conte ◽  
Lorenzo Rocchi ◽  
Andrea Nardella ◽  
Sabrina Dispenza ◽  
Alessandra Scontrini ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Temporal Discrimination ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Healthy Humans ◽  
Theta Burst

scholarly journals Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9253
Author(s):  
Hai-Jiang Meng ◽  
Na Cao ◽  
Jian Zhang ◽  
Yan-Ling Pi
Keyword(s):  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Intracortical Inhibition ◽  
Corticospinal Excitability ◽  
Dorsal Premotor Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Intracortical Facilitation ◽  
Theta Burst

Background Motor information in the brain is transmitted from the dorsal premotor cortex (PMd) to the primary motor cortex (M1), where it is further processed and relayed to the spinal cord to eventually generate muscle movement. However, how information from the PMd affects M1 processing and the final output is unclear. Here, we applied intermittent theta burst stimulation (iTBS) to the PMd to alter cortical excitability not only at the application site but also at the PMd projection site of M1. We aimed to determine how PMd iTBS–altered information changed M1 processing and the corticospinal output. Methods In total, 16 young, healthy participants underwent PMd iTBS with 600 pulses (iTBS600) or sham-iTBS600. Corticospinal excitability, short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were measured using transcranial magnetic stimulation before and up to 60 min after stimulation. Results Corticospinal excitability in M1 was significantly greater 15 min after PMd iTBS600 than that after sham-iTBS600 (p = 0.012). Compared with that after sham-iTBS600, at 0 (p = 0.014) and 15 (p = 0.037) min after iTBS600, SICI in M1 was significantly decreased, whereas 15 min after iTBS600, ICF in M1 was significantly increased (p = 0.033). Conclusion Our results suggested that projections from the PMd to M1 facilitated M1 corticospinal output and that this facilitation may be attributable in part to decreased intracortical inhibition and increased intracortical facilitation in M1. Such a facilitatory network may inform future understanding of the allocation of resources to achieve optimal motion output.

scholarly journals Attenuation of N2 amplitude of laser-evoked potentials by theta burst stimulation of primary somatosensory cortex

2007 ◽  
Vol 185 (4) ◽  
pp. 611-621 ◽  
Author(s):  
Csaba Poreisz ◽  
Andrea Antal ◽  
Klára Boros ◽  
Nadine Brepohl ◽  
Gábor Csifcsák ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Laser Evoked Potentials ◽  
Theta Burst ◽  
Stimulation Of

Continuous theta-burst stimulation over the primary somatosensory cortex modulates interhemispheric inhibition

Neuroreport ◽  
2013 ◽  
Vol 24 (7) ◽  
pp. 394-398 ◽  
Author(s):  
Christopher M. Zapallow ◽  
Mark F. Jacobs ◽  
Kevin G.H. Lee ◽  
Michael J. Asmussen ◽  
Philemon Tsang ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Interhemispheric Inhibition ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation
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