scholarly journals Hemihepatectomy and Replacement of The Afferent Hepatic Blood Supply in The Dog

HPB Surgery ◽  
1989 ◽  
Vol 1 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Egge J. Boerma ◽  
Herman H. M. de Boer ◽  
M. Niels van der Heyde ◽  
Urbain J. G. M. van Haelst
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Blood Supply ◽  
Liver Blood Flow ◽  
Total Liver

Hemihepatectomy along with portal vein or hepatic artery replacement in dogs was well tolerated, but combined with replacement of both vessels it was lethal because of outflow block and shock. Total liver blood flow should be kept as high as possible during such procedures in man.

Participation of adrenoceptors in liver blood flow regulation in anesthetized dogs

1987 ◽  
Vol 253 (5) ◽  
pp. H1053-H1058
Author(s):  
N. Terada ◽  
S. Koyama ◽  
J. Horiuchi ◽  
T. Takeuchi
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Vascular Resistance ◽  
Adrenergic Receptors ◽  
Liver Blood Flow ◽  
Arterial Blood Flow ◽  
Tissue Blood Flow ◽  
Intact Group ◽  
Arterial Blood

We evaluated involvement of adrenergic receptors in the responses of the hepatic vasculature to reduction either of portal venous flow or hepatic arterial inflow. Portal vein occlusion caused an increase in hepatic arterial blood flow (HAF) and decreases in hepatic arterial pressure (HAP) and hepatic arterial vascular resistance (HAR) in the intact group. After pretreatment with either yohimbine or prazosin, but not propranolol, occlusion of the portal vein produced a greater decrease in HAP as compared with that in the intact group. No significant changes in HAF, HAR, or hepatic tissue blood flow (HTF) occurred after the treatment. These results indicate that the compensatory response of the hepatic arterial vasculature to altered portal blood flow (PVF) is regulated independently of the intrahepatic adrenergic receptors. Hepatic arterial occlusion caused a significant decrease in portal venous pressure, PVF, and HTF. Portal venous vascular resistance (PVR) was reduced slightly, but not significantly. After pretreatment with either yohimbine or prazosin, but not propranolol, occlusion of the hepatic artery produced an opposite effect: to increase PVF and significantly decrease PVR. These results indicate that intrahepatic alpha-adrenoceptors participate in the regulation of portal vascular tone to maintain portal vein pressure at a steady level, when inflow from the hepatic artery is reduced.

Effect of stimulation of hepatic nerves on hepatic O2 uptake and blood flow

1977 ◽  
Vol 232 (6) ◽  
pp. H652-H656
Author(s):  
W. W. Lautt
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Venous Blood ◽  
Neurogenic Vasoconstriction ◽  
Pressure Changes ◽  
Hepatic Nerves ◽  
Stimulation Of

Acute denervation of the liver did not result in changes of oxygen uptake or hemodynamics in the intact liver of the cat. Stimulation of the hepatic nerves resulted in a marked reduction of vascular conductance of the hepatic artery and portal vein (intrahepatic) resulting in almost complete cessation of arterial flow and increased portal blood pressure. The hepatic artery showed a more complete escape from the neurogenic vasoconstriction than did the portal vein. During the stable "escape phase" oxygen delivery was 86% of control, but hepatic extraction of oxygen increased so that oxygen uptake was not altered from control values. The return of oxygen consumption to normal during nerve stimulation suggests that redistribution of hepatic blood flow did not occur. In spite of arterial and portal venous blood pressure changes and changes in gut conductance, oxygen extraction of the gut did not change.

Blocking of the Intrahepatic Blood Circulation. II

1956 ◽  
Vol 185 (1) ◽  
pp. 125-126
Author(s):  
H. L. Popper ◽  
N. C. Jefferson ◽  
H. Necheles
Keyword(s):  
Portal Vein ◽  
Hepatic Artery ◽  
Blood Supply ◽  
Blood Circulation ◽  
Plastic Medium ◽  
Arterial Blood Supply ◽  
Arterial Blood ◽  
Red Lead ◽  
The Media ◽  
Toxic Reactions

In previous work it was found that a relatively small collateral blood supply by the phrenic arteries mainly was adequate to maintain the liver following ligation of the hepatic artery and the portal vein. In order to demonstrate the pathways of the collaterals, normal dogs and dogs that had survived ligation of either the hepatic artery or the portal vein for some time were used. A plastic dissolved in acetone that gelled with water, or mineral oil, or red lead dye suspension, was used for injection. The acetone content of the plastic medium produced toxic reactions. The media were injected into branches of the intact portal vein or into the intact hepatic artery, or into the hepatic artery or the portal vein above the ligature. Blocking of the intrahepatic branches of the hepatic artery caused liver necrosis in every instance, while blocking of the intrahepatic branches of the portal vein was tolerated. Thus, blocking of branches of the hepatic artery demonstrates that the essential collateral arterial blood supply had been interrupted.

Changes Porto-hepatic Blood Flow in Patients with Cirrhosis of the Liver, Combined with Chronic Bronchitis

2016 ◽  
pp. 129-132
Author(s):  
Nataliia Virstyuk ◽  
Iryna Kobitovych ◽  
Olha Gerasymchuk
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Chronic Bronchitis ◽  
Hepatic Artery ◽  
Hepatic Blood Flow ◽  
Blood Flow Velocity ◽  
Splenic Artery ◽  
Splenic Vein ◽  
Resistance Index ◽  
Healthy Individuals

The objective: study the features of porto1hepatic blood flow in patients with alcoholic liver cirrhosis (ALC) in conjunction with chronic bronchitis (CB) according to Doppler ultrasound. Patients and methods. The study involved 60 patients who were hospitalized, 20 ALC patients in stage B according to Child-Pugh without CB (Ist group), 20 ALC patients in stage B according to Child-Pugh combined with CB in the acute phase (IInd group), 20 patients exacerbation of chronic bronchitis, for which there was no evidence of digestive system diseases (IIIrd group). All patients underwent a complex ultrasonic research techniques scanning in B-mode, the VD-mode, color duplex scanning using «Hitachi EUB 7000» ultrasonic scanner connected to the Doppler flourimetr was visualized main arterial and venous vessels of hepatic and splenic pools. Results. Changes porto-hepatic blood flow were most pronounced in patients with ALC in combination with CB when compared with patients of groups I and III (p<0,05) according to the obtained Doppler indices: diameter of the hepatic artery was 5,55±0,19 mm, portal vein – 12,60±0,17 mm, where increased by 159,12% and 53,56%, respectively (p<0,05) higher than those in healthy individuals. The diameter of the splenic artery and splenic vein at the ALC for combination with CB significantly increased compared with control on 31,13% and 35,67%, respectively (p<0,05). Linear and volumetric blood flow rate in portal vein decreased in this group of patients, 60,24% and 22,68%, respectively (p<0,05) compared with healthy individuals, the linear velocity of blood flow in the splenic vein also significantly slowed down compared to the control on 41,06% (p<0,05), and the volumetric blood flow velocity v. lienalis grew by 155,80% (p<0,05). Among the characteristics of the arterial blood flow hepato-splenic system Gosling pulsatility index (PI) and Pursello resistance index (RI) of hepatic artery also Pursello resistance index (RI) of splenic artery significantly grew in ALC patients in combination with CB 147,20%, 65,49% and 32,31%, respectively (p<0,05) compared with the control group. Maximal systolic velocity of blood flow in the hepatic artery of patients – grew by 8,95% (p<0,05). End diastolic blood flow velocity in the hepatic artery tended to decrease on 13,36% (p<0,05) compared with healthy individuals. Conclusion. Violation of porto-hepatic blood flow in patients with ALC is characterized by its redistribution in the veins of the portal system in the direction of the spleen with a decrease in the average linear and the volumetric velocity in the portal and hepatic veins, increasing the resistance index in the interlobar arteries.

Hepatic blood flow distribution: consideration of gravity, liver surface, and norepinephrine on regional heterogeneity

1993 ◽  
Vol 71 (2) ◽  
pp. 128-135 ◽  
Author(s):  
W. Wayne Lautt ◽  
Joshua Schafer ◽  
Dallas J. Legare
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Arterial Occlusion ◽  
Flow Distribution ◽  
Arterial Flow ◽  
Blood Flow Distribution ◽  
Hepatic Arterial Flow ◽  
Venous Flow ◽  
Core Samples

Blood flow distribution within the livers of cats and dogs was assessed using 15-μm microspheres injected into the hepatic artery and portal vein. Representative vertical core samples (n = 11–18) were taken from the thickest part of each liver. Heterogeneity was assessed in several ways. The difference in total flow to different lobes was greater in dogs than in cats, and in dogs, those lobes with highest portal venous flow had lowest hepatic arterial flow. Overall flow variance was very high in both species, with adjacent surface samples in a single lobe showing variance of 15–22% for both vessels. The ratio of highest to lowest flow within core samples averaged 2.1–3.4 for both vessels in both species. The hepatic arterial flow was highest to the surface 2 mm of the liver. Portal flow most often (31% of all samples) showed a pattern of highest flow to the top, graduating down to lowest flow to the bottom (dorsal side) of the vertical cores. However, this pattern appeared much more frequently in the most ventral liver lobes and very seldom in the lobes lying beneath the liver mass. Norepinephrine reduced heterogeneity. Hepatic arterial occlusion for 10 min produced minor and inconsistent reduction of heterogeneity. Rotating cats from back to front and again to back disrupted patterns of distribution but not in a way that could be interpreted as due to effects of gravity. Flow patterns changed with time. The heterogeneity of perfusion appears to be under dynamic and multiple interacting forces.Key words: blood flow distribution, blood flow heterogeneity, hepatic artery, portal vein, liver.

Parathyroid hormone and calcitonin may modulate hepatic IGF-I production in calves

1990 ◽  
Vol 123 (4) ◽  
pp. 471-475 ◽  
Author(s):  
Véronique Coxam ◽  
Marie-Jeanne Davicco ◽  
Denis Durand ◽  
Dominique Bauchart ◽  
Jean-Pierre Barlet
Keyword(s):  
Blood Flow ◽  
Parathyroid Hormone ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Latin Square ◽  
Inorganic Phosphorus ◽  
Hepatic Veins ◽  
Igf I ◽  
Plasma Gh ◽  
Synthetic Salmon Calcitonin

Abstract. Four young milk-fed calves were fitted with catheters chronically implanted in the mesenteric, portal and hepatic veins and in the hepatic artery, and with electromagnetic blood flow probes in the portal vein and hepatic artery, allowing continuous measurement of IGF-I hepatic production. According to a latin square design, these calves received iv mesenteric infusion of calcium (Ca2+; 5 mg/kg) or synthetic salmon calcitonin (sCT; 1 μg/kg), or synthetic bovine parathyroid hormone (1-34) (bPTH; 1 μg/kg), or solvent alone (1.2 ml/kg). Ca2+, sCT or bPTH had no significant effect on portal vein or hepatic artery blood flow. Hypercalcemia observed following Ca2+ infusion did not significantly modify hepatic IGF-I production. sCT decreased plasma Ca2+, inorganic phosphorus and GH concentrations and hepatic IGF-I production. bPTH induced a slight hypercalcemia and hypophosphatemia. It had no significant effect on plasma GH concentration, but increased significantly hepatic IGF-I production. Thus, the anabolic effects of PTH on bone may be partly mediated through an increase in hepatic IGF-I production.

Sign in / Sign up

Export Citation Format

Share Document