scholarly journals Primary Biliary Cirrhosis in HLA-Identical Twin Sisters

1994 ◽  
Vol 8 (2) ◽  
pp. 88-91 ◽  
Author(s):  
Hugh J Freeman ◽  
Robert J Bailey
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Human Leukocyte ◽  
Liver Disorder ◽  
Identical Twin ◽  
Biliary Cirrhosis ◽  
Leukocyte Antigen ◽  
Antimitochondrial Antibody ◽  
Abnormal Immune Response ◽  
History Of ◽  
Genetically Determined

Human leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary biliary cirrhosis. This report documents HLA-identical twins with primary biliary cirrhosis, providing added evidence for a genetically determined abnormal immune response in this liver disorder, possibly to a specific viral or other environmental factor.

scholarly journals Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis

Hepatology ◽  
2011 ◽  
Vol 55 (2) ◽  
pp. 506-511 ◽  
Author(s):  
Takeji Umemura ◽  
Satoru Joshita ◽  
Tetsuya Ichijo ◽  
Kaname Yoshizawa ◽  
Yoshihiko Katsuyama ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Japanese Patients ◽  
Class Ii ◽  
Biliary Cirrhosis ◽  
Leukocyte Antigen

Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis

2005 ◽  
Vol 65 (2) ◽  
pp. 199-205 ◽  
Author(s):  
M.E. Mullarkey ◽  
A.M. Stevens ◽  
W.M. McDonnell ◽  
L.S. Loubiere ◽  
J.A. Brackensick ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Class Ii ◽  
Biliary Cirrhosis ◽  
Leukocyte Antigen ◽  
Caucasian Women

scholarly journals Human leukocyte antigen polymorphisms in italian primary biliary cirrhosis: A multicenter study of 664 patients and 1992 healthy controls

Hepatology ◽  
2008 ◽  
Vol 48 (6) ◽  
pp. 1906-1912 ◽  
Author(s):  
Pietro Invernizzi ◽  
Carlo Selmi ◽  
Francesca Poli ◽  
Sara Frison ◽  
Annarosa Floreani ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Human Leukocyte Antigen ◽  
Multicenter Study ◽  
Human Leukocyte ◽  
Biliary Cirrhosis ◽  
Healthy Controls ◽  
Leukocyte Antigen

Association of primary biliary cirrhosis with human leukocyte antigen DPB1*0501 in Japanese patients

Hepatology ◽  
1993 ◽  
Vol 18 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Takeshi Seki ◽  
Kendo Kiyosawa ◽  
Masao Ota ◽  
Seiichi Furuta ◽  
Hirofumi Fukushima ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Japanese Patients ◽  
Biliary Cirrhosis ◽  
Leukocyte Antigen

Human leukocyte antigen associations in Finnish liver transplantations due to primary sclerosing cholangitis and primary biliary cirrhosis

Open Medicine ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 12-25
Author(s):  
Irma Matinlauri ◽  
Markku Nurminen ◽  
Krister Höckerstedt ◽  
Helena Isoniemi
Keyword(s):  
Liver Disease ◽  
Primary Biliary Cirrhosis ◽  
Human Leukocyte Antigen ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Human Leukocyte ◽  
Positive Association ◽  
Biliary Cirrhosis ◽  
Leukocyte Antigen ◽  
Hla Dr3

AbstractA genetic predisposition has been suggested in primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). The aim of the study was to evaluate human leukocyte antigen (HLA) frequencies and HLA associations in Finnish PSC and PBC patients. The relative frequencies of HLA-A,-B, and-DR antigens were compared between patients with PSC (n=50), or PBC (n=89), transplanted due to end-stage liver disease, and healthy members in the Finnish bone marrow donor registry (n=10000). Prevalence differences, prevalence ratios and the associated large-sample significance probabilities (2-sided P-values) and 95% confidence intervals were calculated.We found a strong positive association between PSC and HLA-B8 and-DR3, and a weak positive association between HLA-A1 and PSC. HLA-DR3 also had a weak positive association with PBC, and a weak negative association between HLA-DR5 and PBC was found. In conclusion, HLA-B8, and-DR3 are susceptible for progressive liver disease in PSC, and HLA-DR3 may also be susceptible for disease progression in PBC. HLA-DR5 may be protective against severe PBC.

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