scholarly journals Human breast tissue characterisation with small-angle X-ray scattering

2004 ◽  
Vol 18 (2) ◽  
pp. 167-176 ◽  
Author(s):  
M. Fernández ◽  
J. Keyriläinen ◽  
M.-L. Karjalainen-Lindsberg ◽  
M. Leidenius ◽  
K. von Smitten ◽  
...  
Keyword(s):  
Small Angle ◽  
Breast Tissue ◽  
Lobular Carcinoma ◽  
Scattering Data ◽  
Model Parameters ◽  
Human Breast ◽  
Human Breast Tissue ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

Small-angle X-ray scattering (SAXS) patterns from breast tissue samples are compared with their histology. Formalin fixed human breast tissue specimens containing ductal and lobular carcinoma were studied. Histo-pathological information is compared with the scattering data, and there is a clear spatial correlation. Supra-molecular organisation of collagen fibrils is modelled and the model is used to create scattering maps. The model parameters include the axial periodicity (d-spacing), radius and packing of the fibrils, and these are derived from comparison with the experimental scattering patterns. Thed-spacing is to 0.5% larger in malignant zones of the tumours than in the healthy zones. There are also characteristic differences in the fibril diameter and packing.

Small-angle x-ray scattering studies of human breast tissue samples

2002 ◽  
Vol 47 (4) ◽  
pp. 577-592 ◽  
Author(s):  
M Fernández ◽  
J Keyriläinen ◽  
R Serimaa ◽  
M Torkkeli ◽  
M-L Karjalainen-Lindsberg ◽  
...  
Keyword(s):  
Small Angle ◽  
Breast Tissue ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Tissue Samples ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

scholarly journals Global Small-Angle X-ray Scattering Data Analysis of Triacylglycerols in the Molten State (Part I)

2018 ◽  
Vol 122 (45) ◽  
pp. 10320-10329 ◽  
Author(s):  
Amin Sadeghpour ◽  
Marjorie Ladd Parada ◽  
Josélio Vieira ◽  
Megan Povey ◽  
Michael Rappolt
Keyword(s):  
Data Analysis ◽  
Small Angle ◽  
Scattering Data ◽  
Molten State ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

scholarly journals Molecular Structure of Sphingomyelin in Fluid Phase Bilayers Determined by the Joint Analysis of Small-Angle Neutron and X-ray Scattering Data

2020 ◽  
Vol 124 (25) ◽  
pp. 5186-5200 ◽  
Author(s):  
Milka Doktorova ◽  
Norbert Kučerka ◽  
Jacob J. Kinnun ◽  
Jianjun Pan ◽  
Drew Marquardt ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Small Angle ◽  
Fluid Phase ◽  
Scattering Data ◽  
Joint Analysis ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

scholarly journals Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue

2005 ◽  
pp. 118-121 ◽  
Author(s):  
Vahid Changizi ◽  
Mohammad A. Oghabian ◽  
Robert Speller ◽  
Saeed Sarkar ◽  
Ali Arab Kheradmand
Keyword(s):  
Small Angle ◽  
Breast Tissue ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

Recent developments in small-angle X-ray scattering and hybrid method approaches for biomacromolecular solutions

2018 ◽  
Vol 2 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Martin A. Schroer ◽  
Dmitri I. Svergun
Keyword(s):  
Small Angle ◽  
Scattering Data ◽  
Quality Data ◽  
Biological Macromolecules ◽  
Ambient Conditions ◽  
X Ray ◽  
X Ray Scattering ◽  
Analysis Methods ◽  
Recent Developments ◽  
Ray Scattering

Small-angle X-ray scattering (SAXS) has become a streamline method to characterize biological macromolecules, from small peptides to supramolecular complexes, in near-native solutions. Modern SAXS requires limited amounts of purified material, without the need for labelling, crystallization, or freezing. Dedicated beamlines at modern synchrotron sources yield high-quality data within or below several milliseconds of exposure time and are highly automated, allowing for rapid structural screening under different solutions and ambient conditions but also for time-resolved studies of biological processes. The advanced data analysis methods allow one to meaningfully interpret the scattering data from monodisperse systems, from transient complexes as well as flexible and heterogeneous systems in terms of structural models. Especially powerful are hybrid approaches utilizing SAXS with high-resolution structural techniques, but also with biochemical, biophysical, and computational methods. Here, we review the recent developments in the experimental SAXS practice and in analysis methods with a specific focus on the joint use of SAXS with complementary methods.

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