Small-angle x-ray scattering studies of human breast tissue samples

Small-angle X-ray scattering (SAXS) patterns from breast tissue samples are compared with their histology. Formalin fixed human breast tissue specimens containing ductal and lobular carcinoma were studied. Histo-pathological information is compared with the scattering data, and there is a clear spatial correlation. Supra-molecular organisation of collagen fibrils is modelled and the model is used to create scattering maps. The model parameters include the axial periodicity (d-spacing), radius and packing of the fibrils, and these are derived from comparison with the experimental scattering patterns. Thed-spacing is to 0.5% larger in malignant zones of the tumours than in the healthy zones. There are also characteristic differences in the fibril diameter and packing.

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Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue

International Journal of Medical Sciences ◽

10.7150/ijms.2.118 ◽

2005 ◽

pp. 118-121 ◽

Cited By ~ 12

Author(s):

Vahid Changizi ◽

Mohammad A. Oghabian ◽

Robert Speller ◽

Saeed Sarkar ◽

Ali Arab Kheradmand

Keyword(s):

Small Angle ◽

Breast Tissue ◽

X Ray ◽

X Ray Scattering ◽

Ray Scattering

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Assessing lesion malignancy by scanning small-angle x-ray scattering of breast tissue with microcalcifications

Physics in Medicine and Biology ◽

10.1088/1361-6560/ab2c36 ◽

2019 ◽

Vol 64 (15) ◽

pp. 155010

Author(s):

C Arboleda ◽

V Lutz-Bueno ◽

Z Wang ◽

P Villanueva-Perez ◽

M Guizar-Sicairos ◽

...

Keyword(s):

Small Angle ◽

Breast Tissue ◽

X Ray ◽

X Ray Scattering ◽

Ray Scattering

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Elemental silicone analysis in human breast and capsular tissue surrounding prostheses and expanders

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100161795 ◽

1990 ◽

Vol 48 (3) ◽

pp. 846-847

Author(s):

Debby Jennings ◽

Michael Morykwas ◽

Anthony DeFranzo ◽

Louis Argenta

Keyword(s):

Breast Tissue ◽

Subcutaneous Tissue ◽

Capsular Contraction ◽

Human Breast ◽

Human Breast Tissue ◽

Double Lumen ◽

Tissue Samples ◽

Capsule Formation ◽

X Ray ◽

Single Lumen

polydimethylsiloxane is the most frequently used polymer for manufacture of breast prostheses and soft tissue expanders. The diffusion of lower molecular weight molecules and there lease of silicafiller from the outer shell have been speculated to cause capsular contraction (capsule formation is normal, capsular contraction is pathologic). Previous research has identified silicone in the tissue surrounding gel-filled implants. This preliminary project analyzed human breast tissue and capsular tissue from around expanders and implants for the presence of silicone by electron dispersive x-ray analysis (EDXA).Tissue samples were divided into four categories based on device: single lumen, standard bleed gel filled implant (n=2); single lumen, low bleed gel filled implant (n=2); double lumen (saline outer lumen) gel filled implant (n=3); and expander or inflatable prostheses (nogel) (n=4). Breast and subcutaneous tissue external to the capsules were used as controls (n=4).

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