scholarly journals Synthesis, Characterization and Antimicrobial Activity of 5-(4-Methyl piperazinyl methylene)-8-hydroxy quinoline and its Various Metal Chelates

2006 ◽  
Vol 3 (3) ◽  
pp. 110-116 ◽  
Author(s):  
I. J. Patel ◽  
I. M. Vohra
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Antifungal Activity ◽  
Sodium Bicarbonate ◽  
Antifungal Agents ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Transition Metal Chelates ◽  
Hydroxy Quinoline ◽  
Metal Ligand

5-Chloromethyl-8-quinolinol was condensed with 4-methyl piperazine in presence of sodium bicarbonate. The resulting 5-(4-methyl piper-azinylmethylene)-8-quinolinol (MPQ) was characterized by elemental analysis and spectral studies. The transition metal chelatesvizCu+2, Ni+2, Co+2, Mn+2, Zn+2, Cd+2, and Fe+3of MPQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of MPQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5-[4-Chloro phenyl(1, 3, 4)thiadiazol-2-ylamino methylene]-8-hydroxy quinoline

2009 ◽  
Vol 6 (4) ◽  
pp. 1017-1022 ◽  
Author(s):  
Divyesh K. Patel ◽  
Arun Singh
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Antifungal Activity ◽  
Sodium Bicarbonate ◽  
Antifungal Agents ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Transition Metal Chelates ◽  
Hydroxy Quinoline ◽  
Metal Ligand

5-Chloromethyl-8-quinolinol was condensed stoichiometrically with 5-(4-chlorophenyl)-(1,3,4) thiadiazol-2-ylamine in the presence of sodium bicarbonate. The resulting 5-[4-chlorophenyl-(1,3,4)thiadiazol-2-ylamino methylene]-8-quinolinol (CTAQ) was characterized by elemental analysis and spectral studies. The transition metal chelatesviz. Cu2+, Ni2+, Co2+, Mn2+and Zn2+of CTAQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of CTAQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5-[1(H)-Benzotriazole methylene]-8-quinolinol

2009 ◽  
Vol 6 (2) ◽  
pp. 371-376 ◽  
Author(s):  
H. S. Patel ◽  
K. K. Oza
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Antifungal Agents ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Transition Metal Chelates ◽  
Metal Ligand

5-Chloromethyl-8-quinolinol was condensed stoichiometrically with benzotriazole in presence of potassium carbonate. The resulting 5-[1(H)-benzo triazole methylene]-8-quinolinol (BTMQ) was characterized by elemental analysis and spectral studies. The transition metal chelatesviz. Cu2+, Ni2+, Co3+, Mn2+and Zn2+of BTMQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectral studies and magnetic properties. The antifungal activity of BTMQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5-(4-N, N-Diethylamino sulfonyl phenyl azo)-8-hydorxy quinoline

2009 ◽  
Vol 6 (4) ◽  
pp. 1247-1252 ◽  
Author(s):  
A. U. Patel
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Elemental Analysis ◽  
Antifungal Agents ◽  
Reflectance Spectroscopy ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Transition Metal Chelates ◽  
Anti Fungal ◽  
Metal Ligand

4-N,N-Diethylamino sulfonyl phenyl amine was synthesized by diazotization and coupled with 8-hydroxyquinoline. The resultant 5-(4-N,N-diethylamino sulfonyl phenyl azo)-8-hydorxy quinoline (DSAQ) was characterized by elemental analysis and spectral studies. The transition metal chelatesviz. Cu2+, Ni2+, Co2+, Mn2+and Zn2+of DSAQ were prepared and characterized by metal-ligand (M:L) ratio. IR and reflectance spectroscopy and magnetic properties. The anti fungal activity of DSAQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

scholarly journals Synthesis, Characterisation, Spectral and Microbial Studies of Transition Metal Complexes of the Drug, Secnidazole

2010 ◽  
Vol 7 (s1) ◽  
pp. S520-S526
Author(s):  
Aradhana Verma ◽  
S. A. Iqbal ◽  
Arun Singh ◽  
Liviu Mitu
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Transition Metal ◽  
Transition Metal Complexes ◽  
Potassium Carbonate ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Gram Negative ◽  
Transition Metal Chelates ◽  
Gram Negative Organisms

5-Chloromethyl-8-quinolinol hydrochloride was condensed with 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol in presence of potassium carbonate. The resulting 5-((1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yloxy)methyl)quinolin-8-ol was characterized by elemental analysis and spectral studies. The transition metal chelates of the same were prepared with Cu2+, Ni2+, Co2+, Mn2+and Zn2+and characterized by IR and electronic spectral studies and magnetic properties. The antimicrobial activity of ligand and its metal chelates were screened against various gram positive and gram negative organisms. The results show that all these samples are more or less active agents against various organisms.

scholarly journals Synthesis, characterization and chelating properties of tannin-8-hydroxy quinoline - formaldehyde polymer

2020 ◽  
Vol 5 (2) ◽  
pp. 019-023
Author(s):  
Sasikala T ◽  
Greeshma KP ◽  
Gnana Priya K ◽  
Muthulingam S ◽  
Nandhakumar C
Keyword(s):  
Antimicrobial Activity ◽  
Metal Chelate ◽  
Magnetic Moments ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Chelate Formation ◽  
Transition Metal Chelates ◽  
Uv Visible ◽  
Hydroxy Quinoline ◽  
Eucalyptus Plant

Tannin obtained from Eucalyptus plant, condensed with formaldehyde and then 8-hydroxy quinoline. The so called obtained polymer designated as TFQ was used for metal chelate formation. Thus Transition metal chelates of TFQ with Zn+2, Co+2, Cu+2, Ni+2 and Mn+2 metal ions were prepared. The ligand TFQ and its all five metal chelates were characterized by nitrogen content, IR, UV-Visible spectral studies, magnetic moments and thermogravimetry. The antimicrobial activity of all the samples has also been monitored against common microbes.

scholarly journals Synthesis, Characterization and Chelating Properties of 4-Butyrylsemicarbazone-1-phenyl-3-methyl-2-pyrazolin-5-one

2010 ◽  
Vol 7 (2) ◽  
pp. 357-362 ◽  
Author(s):  
J. D. Patel ◽  
P. J. Shah
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Elemental Analysis ◽  
Metal Chelates ◽  
Spectral Studies

4-Butyrylsemicarbazone-1-phenyl-3-methyl-2-pyrazolin-5-one (BUMP-SC) was prepared and its metal chelates of Cu2+, Ni2+, Co2+, Mn2+, Fe2+, Fe3+, Cr3+, UO2and OV were prepared. The ligands and its chelates were characterized by elemental analysis, metal:ligand (M:L) stoichiometry, IR-electronic spectral studies and magnetic properties. The compounds also were screened for their antimicrobial activity.

scholarly journals Synthesis Characterization and Antimicrobial Activity of Metal Chelates of 1, 7-Di (2-hydroxyphenyl) 1, 7 di (N-methyl) aza-1, 3, 5 heptarine-3-ol hydrochloride

2010 ◽  
Vol 7 (3) ◽  
pp. 775-778
Author(s):  
Nalin P. Patani ◽  
M. V. Hathi
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
Ir Reflectance ◽  
Amino Phenol ◽  
Metal Ligand

The Schiff base complexes derived from 2-furancarboxaldehyde and N-methyl-2-amino phenol have been prepared and characterized using several physical techniques, like elemental analysis, thermogravimetric analysis, magnetic moment measurements, infrared and resonance spectra.N-Methyl-2-amino phenol was condensed stoichiometrically with 2-furancarboxaldehyde in presence of methanol. The resulting 1,7-di(2-hydroxyphenyl) 1,7 di(N-methyl) aza-1,3,5 heptarine-3-ol hydrochloride was characterized by elemental analysis and spectral studies. The transition metal complexes of Cu2+, Zn2+, Ni2+, Co2+and Mn2+of the synthesized complexes were prepared. Metal ligand (M:L) ratio, IR, reflectance spectral studies, magnetic properties and antimicrobial activity of the synthesized complexes and its metal complexes were carried out.

scholarly journals Synthesis, antimicrobial and antimalarial activityof1, 4-benzothiazepine and pyrazolinederivatives incorporating carbazolemoiety

2019 ◽  
Vol 51 (2) ◽  
pp. 234-241
Author(s):  
V. A. Kadnor ◽  
S. N. Shelke
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
13C Nmr ◽  
Antimalarial Activity ◽  
Positive Control ◽  
Spectral Studies ◽  
Standard Drug ◽  
Mass Spectral ◽  
Ft Ir

A series of carbazole-based 1,4-benzothiazepine and pyrazoline derivatives were synthesized and the structures of the newly synthesized compounds were confirmed by FT-IR, 1H NMR, 13C NMR and mass spectral studies. All new derivatives 4(a-f) and 5(a-e) were screened for their in vitro antimicrobial activity, and also for their antimalarial activity. Compounds 4a, 4b, 4d, 5a, 5b and 5c exhibited promising antimicrobial and antimalarial activities as compared to positive control. Notably, compounds 4a, 4b and 4d showed excellent antifungal activity against Penicillium sp. comparable to that of a standard drug.

scholarly journals Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes

2009 ◽  
Vol 6 (s1) ◽  
pp. S445-S451
Author(s):  
R. T. Vashi ◽  
S. B. Patel
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Hydroxyl Groups ◽  
Tetrahedral Geometry ◽  
Distorted Octahedral ◽  
Metal Ligand ◽  
Methyl Phenyl

Novel ligands containing quinazoline-4-one-8-hydroxyquinoline (QQ) merged moieties were prepared and characterized. For this anthranilic acid and 5-bromoanthranilic acid were converted respectively into 2-chloromethyl–3-(4-methyl phenyl)-3(H)-quinazoline-4-one and 2-chloromethyl–3-(methyl phenyl)-6-bromo-3(H)-quinazoline-4-one. Both these compounds were condensed with 5-amino-8-hydroxyquinoline. The so called resulted compounds were named respectively as 2-[(8-hydroxy-quinolinyl) –5- amino methyl] -3-(4-methylphenyl)- 3(H)- quinazoline -4- one and 2-[(8-hydroxyquinolinyl)-5-aminomethyl] -3(methyl phenyl)-6-bromo-3(H)-quinazoline-4-one. Both the compounds were designated respectively as HL1and HL2ligands. The transition metal (Cu2+, Ni2+, Zn2+, Mn2+and Co2+) complexes of both these ligands were prepared. The ligands and their complexes as case may be were characterized by elemental analysis, spectral studies and number of hydroxyl groups. The stoichiometry of the complexes has been found to be 1:2 (metal: ligand). An octahedral geometry around Co2+, Ni2+and Mn2+, distorted octahedral geometry around Cu2+and tetrahedral geometry of around Zn2+have been proposed. These complexes also been tested for their antifungal activities.

scholarly journals Synthesis, Characterizations and Antimicrobial Activity of Metal Complexes of 2-(2-Furanylmethylaminocarbonyl)benzoic Acid

2011 ◽  
Vol 8 (1) ◽  
pp. 443-448 ◽  
Author(s):  
R. H. Patel ◽  
B. L. Hiran
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Transition Metal ◽  
Benzoic Acid ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moments ◽  
Thermal Studies ◽  
Spectral Studies

The ligand, 2-(2-furanylmethylaminocarbonyl)benzoic acid (FMBA) and it’s transition metal complexes have been synthesized and characterized by elemental analysis, spectral studies, magnetic moments and thermal studies. The antifungal activity of all the samples was monitored against common fungi.

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