A quinoline-benzothiazole based chemosensor coupled with smart phone for rapid detection of In3+ ions

A newly designed quinoline-benzothiazole probe 2-((Z)-((E)-benzo[d]thiazol-2(3H)-ylidenehydrazono)methyl)quinolin-8-ol (L) was synthesized by reacting 8-hydroxy quinoline-2-carbaldehyde with 2-hydrazinobenzothiazole and structurally characterized by various spectroscopic techniques. Sensing ability of probe L was studied with...

Cloud Point Extraction with Liquid Ion Exchange for Separation and Determination Magnesium (II) as anion

Liquid Ion Exchange joined with Cloud point extraction methodology was used for the separation of Magnesium (II) from aqueous and determine whereas 10 mL aqueous solution that contains 50 µg Mg2+ ion is complex with 1×10-3M 8-Hydroxy quinoline (8-HQ) at a suitable basic medium it well give higher extraction efficiency at optimum conditions, needs heating the aqueous solution in suitable temperature degree for enough time to form a cloud point layer (CPL). Therefore, the optimum conditions that yielded the good CPL have a small aggregation volume which is appropriate for continuing the ion pair association Complex between Magnesium ion and 8-Hydroxy quinoline.

Effect of Floral Preservatives and Growth Regulators on Post Harvest Life of Gladiolus (Gladiolus grandiflorus L.) cv. American Beauty

A Postharvest experiment was conducted to maximize the vase life of gladiolus using different preservative solution in department of Horticulture, Kalasalingam School of Agriculture and Horticulture. In this experiment the treatment consisted of two preservative chemicals and two growth regulators viz., 8-Hydroxy quinoline sulphate @ 300 ppm Silver nitrate @ 50 ppm, Benzyl adenine @ 20,40,60 ppm and Gibberlic acid @ 10,25,40 ppm along with sucrose @ 4 per cent with distilled water as control. The results of this experiment revealed that the maximum water uptake, transpirational loss of water, water balance, fresh weight change, percentage of opened florets, floret diameter, longevity of floret, vase life was recorded in T2 (8-HQS @ 300 ppm + sucrose 4% + BA @ 40 ppm), when compared to control. Some parameters like optical density of vase solution, days taken for the basal floret to open in vase and the percentage of wilted florets were observed least in T2 (8-HQS @ 300 ppm + sucrose 4% + BA @ 40 ppm). T5 (8-HQS @ 300 ppm + Sucrose 4% + BA @ 40 ppm) solution was found best to extend the vase life of gladiolus.

Effect of Floral Preservatives on Post Harvest Life of Gladiolus (Gladiolus grandiflorus L.) cv. American Beauty

A Postharvest experiment was conducted to maximize the vase life of gladiolus using different preservative solution in Department of Horticulture, Faculty of Agriculture, Annamalai University. In this experiment the treatment consisted of two preservative chemicals viz., 8-hydroxy quinoline sulphate @ 150, 300, 450 ppm and silver nitrate @ 25, 50, 75 ppm along with sucrose @ 2 and 4 per cent along with control (distilled water). The results of this experiment revealed that the maximum water uptake, transpirational loss of water, water balance, fresh weight change, percentage of opened florets, floret diameter, longevity of floret, vase life was recorded in T5 (8-HQS @ 300 ppm + sucrose 4%), when compared to control. Some parameters like optical density of vase solution, days taken for the basal floret to open in vase and the percentage of wilted florets were observed least in T5 (8-HQS @ 300 ppm + sucrose 4%). T5 (8-HQS @ 300 ppm + Sucrose 4%) solution was found best to extend the vase life of gladiolus.

An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling

Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital lethality. It is evidenced that LPS, the major pathological component of the Gram-negative bacteria membrane, predominantly contributes to the pathogenesis of sepsis. Cytoplasmic lipopolysaccharide (LPS) can be sensed by the noncanonical inflammasome and triggers the oligomerization of caspase-11, resulting in pyroptosis and lethal immune responses in sepsis. A previous study has shown that hepatocyte-released high mobility group box 1 (HMGB1) mediates caspase-11–dependent lethality in sepsis by delivering extracellular LPS into the cytosol. Here, we established a phenotypic screening system using recombinant HMGB1 plus LPS in mouse peritoneal macrophages, identifying a novel 8-hydroxyquinoline derivative named 7-[phenyl (pyridin-2-ylamino) methyl] quinolin-8-ol (8-ol, NSC84094) that can specifically inhibit HMGB1-mediated caspase-11 signaling. 8-ol targets directly to HMGB1 and changes the secondary conformation, consequently disrupting the interaction between LPS and HMGB1 and inhibiting the HMGB1-mediated delivery of LPS into the cytosol. Intervention of 8-ol significantly reduced the release of IL-1α and IL-1β and protected against caspase-11–mediated organ injury and lethality in endotoxemic mice. Thus, this study clearly suggests that the HMGB1–caspase-11 pathway is a potential drug target in lethal immune disorders and might open a new avenue in the treatment of sepsis.