scholarly journals Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

2007 ◽  
Vol 2007 ◽  
pp. 1-9 ◽  
Author(s):  
Jinhwa Jang ◽  
Hee-Jin Ha ◽  
Yun Bok Kim ◽  
Young-Ki Chung ◽  
Min Whan Jung
Keyword(s):  
Prefrontal Cortex ◽  
Firing Rate ◽  
Medial Prefrontal Cortex ◽  
Unit Activity ◽  
Single Unit ◽  
Discharge Rate ◽  
Rate Change ◽  
Psychotic Symptoms ◽  
Single Unit Activity

To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.

Effects of ouabain on neuronal thermosensitivity in hypothalamic tissue slices

1989 ◽  
Vol 257 (1) ◽  
pp. R21-R28
Author(s):  
M. C. Curras ◽  
J. A. Boulant
Keyword(s):  
Firing Rate ◽  
Neuronal Activity ◽  
Unit Activity ◽  
Single Unit ◽  
Single Unit Activity ◽  
Tissue Slices ◽  
Temperature Changes ◽  
Cold Sensitive ◽  
Hypothalamic Tissue

To determine the role of the electrogenic Na+-K+ pump in neuronal thermosensitivity, single-unit activity was recorded in rat hypothalamic tissue slices before, during, and after perfusions containing 10(-5) or 10(-6) M ouabain, a specific pump inhibitor. Most neurons were recorded in the preoptic-anterior hypothalamus. Some neurons were also tested with high magnesium-low calcium perfusions to determine ouabain's effects on neuronal activity during synaptic blockade. When the neurons were characterized according to thermosensitivity, 24% were warm sensitive, 8% were cold sensitive, and 68% were temperature insensitive. Ouabain increased the firing rate of 60% of all neurons. Ouabain did not reduce the thermosensitivity of cold-sensitive and warm-sensitive neurons; however, temperature-insensitive neurons became more warm sensitive during ouabain perfusion. This increase in warm sensitivity did not occur with ouabain plus high Mg2+-low Ca2+ perfusion, suggesting that Ca2+ is important in this response. These results indicate that the Na-K pump is not responsible for the thermosensitivity of hypothalamic cold-sensitive or warm-sensitive neurons; however, this pump may be actively employed by many neurons that remain insensitive to temperature changes.

scholarly journals In Vivo Recording of Single-Unit Activity during Singing in Zebra Finches

2014 ◽  
Vol 2014 (12) ◽  
pp. pdb.prot084624 ◽  
Author(s):  
Tatsuo S. Okubo ◽  
Emily L. Mackevicius ◽  
Michale S. Fee
Keyword(s):  
Unit Activity ◽  
Single Unit ◽  
Zebra Finches ◽  
Single Unit Activity

Single unit activity during a Go/NoGo task in the “prefrontal cortex” of pigeons

1999 ◽  
Vol 839 (2) ◽  
pp. 263-278 ◽  
Author(s):  
T Kalt ◽  
B Diekamp ◽  
O Güntürkün
Keyword(s):  
Prefrontal Cortex ◽  
Unit Activity ◽  
Single Unit ◽  
Single Unit Activity
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