LOCAL FIELD POTENTIAL AND SINGLE UNIT ACTIVITY IN THE RAT MEDIAL PREFRONTAL CORTEX AND ANTERIOR CINGULATE CORTEX DURING A SUSTAINED ATTENTION TASK

2010 ◽  
Vol 117 (2-3) ◽  
pp. 481
Author(s):  
Nelson K. Totah ◽  
Mark Jackson ◽  
Bita Moghaddam
2011 ◽  
Vol 21 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Shaomin Zhang ◽  
Bo Jiang ◽  
Junming Zhu ◽  
Qiaosheng Zhang ◽  
Weidong Chen ◽  
...  

2007 ◽  
Vol 2007 ◽  
pp. 1-9 ◽  
Author(s):  
Jinhwa Jang ◽  
Hee-Jin Ha ◽  
Yun Bok Kim ◽  
Young-Ki Chung ◽  
Min Whan Jung

To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.


2018 ◽  
Vol 14 ◽  
pp. 174480691878568 ◽  
Author(s):  
Bo Fu ◽  
Shao-nan Wen ◽  
Bin Wang ◽  
Kun Wang ◽  
Ji-yan Zhang ◽  
...  

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