scholarly journals Wegener Granulomatosis Revealed by Pleural Effusion

2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
Anne-Claire Toffart ◽  
François Arbib ◽  
Sylvie Lantuejoul ◽  
Jean-François Roux ◽  
Vincent Bland ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Clinical Manifestation ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Pleural Biopsy ◽  
Wegener Granulomatosis ◽  
Pleural Thickening ◽  
Open Lung ◽  
Granulomatous Vasculitis

Pulmonary signs are common in Wegener's granulomatosis (WG). However, an initial presentation including pleural effusion has not been described. We describe a case of WG in which pleural effusion was the first clinical manifestation. A 45-year-old man with dorsal pain presented with pleural thickening and effusion, and a visible nodule on a thoracic scan. A dense chronic inflammatory infiltrate was obtained by pleural biopsy and an open lung biopsy revealed necrotizing granulomatous vasculitis. Serologies were positive for antineutrophil cytoplasmic antibodies and antiproteinase 3 antibodies. A diagnosis of WG was conducted and the patient was started on cyclophosphamide and methylprednisolone as an initial treatment, with a favorable evolution. Although pleural effusion is rarely described in WG, this pathology must be considered in the presence of this clinical manifestation.

scholarly journals Investigating the Role of Open Lung Biopsy in Diagnosing the Type of Chronic Lung Disease in Children

2020 ◽  
pp. 1-6
Author(s):  
Ashjaei Bahar ◽  
Ashjaei Bahar ◽  
Modaresi Mohammadreza ◽  
Amiri Shakiba ◽  
Najdi Fatemeh ◽  
...  
Keyword(s):  
Side Effects ◽  
Pleural Effusion ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Lung Biopsy ◽  
Medical Center ◽  
Open Lung Biopsy ◽  
Thoracic Wall ◽  
Open Lung ◽  
Chronic Pulmonary Diseases

Objective: This study was conducted for the practical use of biopsy in the diagnosis of chronic lung disease and the guidance of risks and benefits. Design of Study: We studied 64 children with chronic lung disease who underwent open lung biopsy in 5 years at the Children's Medical Center . Results: Biopsy results were diagnostic in 57 cases (89.1%) and non-diagnostic in 7 cases (10.9%). The biopsy determined the type of mass in all cases where a possible diagnosis of lung mass or thoracic wall was made. In 37 cases (57.8%) the diagnosis was changed and the exact diagnosis was determined. The main side effects (including pneumothorax, hemothorax, pyothorax, and pleural effusion) were 50% (32 cases), the most common of which were pneumothorax and pleural effusion, with a total of more than 87% of these major complications. 22 patients (34.4%) required intubation. 24 patients (37.5%) were admitted to the ICU after surgery. The death occurred in only one case, who was a 3-month-old boy with a disorder of INR and suffering from acute respiratory distress syndrome. There was no mortality that could be directly related to surgery. Conclusion: Open lung biopsy is a gold standard for the histological diagnosis of chronic pulmonary disease in children and plays an important role in the treatment of children with chronic pulmonary diseases. However, serious and common side effects of this method should be considered

Open lung biopsy in patients on mechanical ventilation with suspected diffuse lung disease

2009 ◽  
Vol 15 (4) ◽  
pp. 597-611
Author(s):  
Natália Melo ◽  
Sandra Figueiredo ◽  
António Morais ◽  
Conceição Souto Moura ◽  
Paulo Pinho ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Diffuse Lung Disease ◽  
Open Lung ◽  
Diffuse Lung

Diagnostic Open Lung Biopsy in the Critically Ill Child

PEDIATRICS ◽  
1973 ◽  
Vol 52 (4) ◽  
pp. 605-608
Author(s):  
Stacy A. Roback ◽  
William H. Weintraub ◽  
Mark Nesbit ◽  
Panayiotis K. Spanos ◽  
Barbara Burke ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Critically Ill ◽  
Lung Tissue ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
University Of Minnesota ◽  
Biopsy Technique ◽  
Open Lung ◽  
Critically Ill Child ◽  
The University

Forty-six open biopsies in 40 acutely ill children with rapidly decreasing pulmonary reserve were performed at the University of Minnesota Hospitals between January 1, 1970, and January 1, 1972. Tissue obtained was adequate in all patients and no serious complications ensued. Information obtained resulted in the change in treatment in 30 patients. This procedure is recommended over closed biopsy when the magnitude of the patient's illness and degree of pulmonary function do not allow acceptance of the risks known to occur with a closed biopsy technique and when histologic examination of lung tissue is required.

Open lung biopsy in patients with acute leukemia

1985 ◽  
Vol 78 (4) ◽  
pp. 609-616 ◽  
Author(s):  
Robert E. McCabe ◽  
Robert G. Brooks ◽  
James B.D. Mark ◽  
Jack S. Remington
Keyword(s):  
Acute Leukemia ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Open Lung

scholarly journals Open Lung Biopsy for Diffuse Pulmonary Lesions

BMJ ◽  
1960 ◽  
Vol 1 (5165) ◽  
pp. 17-21 ◽  
Author(s):  
L. J. Grant ◽  
S. A. Trivedi
Keyword(s):  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Pulmonary Lesions ◽  
Open Lung

Pulmonary Fibrosis Induced by Cyclophosphamide

2001 ◽  
Vol 35 (7-8) ◽  
pp. 894-897 ◽  
Author(s):  
Angel Segura ◽  
Ana Yuste ◽  
Ana Cercos ◽  
Pedro López-Tendero ◽  
Regina Gironés ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulmonary Fibrosis ◽  
Lung Biopsy ◽  
Pulmonary Function Tests ◽  
Diagnostic Technique ◽  
Open Lung Biopsy ◽  
Pulmonary Insufficiency ◽  
Open Lung ◽  
Case Summary ◽  
High Doses

OBJECTIVE: To report a case of pulmonary fibrosis resulting from use of cyclophosphamide as chemotherapy to treat a patient with breast cancer. CASE SUMMARY: We describe the case of a 52-year-old woman with breast cancer who developed pulmonary fibrosis after four cycles of chemotherapy that included cyclophosphamide. Pulmonary function tests revealed the presence of a severe ventilatory restriction. The open lung biopsy revealed pulmonary fibrosis with vascular sclerosis and signs of pulmonary hypertension. DISCUSSION: Cyclophosphamide is an alkylating agent that has been associated with interstitial pneumonia and pulmonary fibrosis. The frequency of these unwanted effects is '1%. The clinical picture consists of the progressive appearance of dyspnea and a nonproductive cough that progresses to severe pulmonary insufficiency. The risk factors described for these complications have been the use of chemotherapy regimens that include other drugs with known pulmonary toxicities, the cumulative total dose, the addition of radiotherapy, and the use of high doses of cyclophosphamide. CONCLUSIONS: Even though the frequency of pulmonary fibrosis in patients treated with cyclophosphamide-based chemotherapy regimens is low, the presence of dyspnea and an interstitial pattern in a patient makes it necessary to consider that possible drug toxicity. The open lung biopsy is the most accurate diagnostic technique for these cases. The discontinuation of cyclophosphamide and treatment with corticosteroids is usually followed by clinical recovery in approximately 50% of patients and, in some cases, reversal of the lung injury.

Open Lung Biopsy

1981 ◽  
Vol 12 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Jerrold L. Abraham
Keyword(s):  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Open Lung
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