Successful Treatment of a Prosthetic Joint Infection due toMycobacterium abscessus

Prosthetic joint infection due toMycobacterium abscessusis uncommon and optimal therapy remains poorly defined. Following a two-stage revision, clinical and microbiological cure was achieved in a patient with aM abscessus-infected total hip arthroplasty. A prolonged course of directed antibacterial therapy comprising clarithromycin and cefoxitin coupled with the application of amikacin-impregnated cement likely contributed to the successful outcome.

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Proton-pump inhibitors are associated with increased risk of prosthetic joint infection in patients with total hip arthroplasty: a case-cohort study

Acta Orthopaedica ◽

10.1080/17453674.2021.1920687 ◽

2021 ◽

pp. 1-5

Author(s):

Maarten M Bruin ◽

Ruud L M Deijkers ◽

Roos Bazuin ◽

Erika P M Elzakker ◽

Bart G Pijls

Keyword(s):

Cohort Study ◽

Total Hip Arthroplasty ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Hip Arthroplasty ◽

Prosthetic Joint Infection ◽

Joint Infection ◽

Total Hip ◽

Prosthetic Joint ◽

Increased Risk

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Outcomes of repeat two-stage exchange hip arthroplasty for prosthetic joint infection

The Bone & Joint Journal ◽

10.1302/0301-620x.101b6.bjj-2018-1556.r1 ◽

2019 ◽

Vol 101-B (6_Supple_B) ◽

pp. 110-115 ◽

Cited By ~ 10

Author(s):

N. Khan ◽

D. Parmar ◽

M. S. Ibrahim ◽

B. Kayani ◽

F. S. Haddad

Keyword(s):

Hip Arthroplasty ◽

Prosthetic Joint Infection ◽

Joint Infection ◽

Antimicrobial Treatment ◽

Successful Outcome ◽

Two Stage ◽

Persistent Symptoms ◽

Prosthetic Joint ◽

Revision Tha

Aims The increasing infection burden after total hip arthroplasty (THA) has seen a rise in the use of two-stage exchange arthroplasty and the use of increasingly powerful antibiotics at the time of this procedure. As a result, there has been an increase in the number of failed two-stage revisions during the past decade. The aim of this study was to clarify the outcome of repeat two-stage revision THA following a failed two-stage exchange due to recurrent prosthetic joint infection (PJI). Patients and Methods We identified 42 patients who underwent a two-stage revision THA having already undergone at least one previous two stage procedure for infection, between 2000 and 2015. There were 23 women and 19 men. Their mean age was 69.3 years (48 to 81). The outcome was analyzed at a minimum follow-up of two years. Results A satisfactory control of infection and successful outcome was seen in 26 patients (57%). There therefore remained persistent symptoms that either required further surgery or chronic antibiotic suppression in 16 patients (38%). One-third of patients had died by the time of two years’ follow-up. Conclusion The rate of failure and complication rate of repeat two-stage exchange THA for PJI is high and new methods of treatment including host optimization, immunomodulation, longer periods between stages, and new and more powerful forms of antimicrobial treatment should be investigated. Cite this article: Bone Joint J 2019;101-B(6 Supple B):110–115.

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