scholarly journals Spectrophotometric Determination of Ezetimibe

2010 ◽  
Vol 7 (1) ◽  
pp. 101-104 ◽  
Author(s):  
P. Baby Sudha Lakshmi ◽  
D. Ramchandran ◽  
C. Rambabu
Keyword(s):  
Complex Formation ◽  
Spectrophotometric Determination ◽  
Ferric Chloride ◽  
Spectrophotometric Method ◽  
Pharmaceutical Formulations ◽  
Complex Formation Reaction ◽  
Formation Reaction ◽  
Bulk Drug

Two simple, sensitive, selective and accurate spectro-photometric methods (Method A and Method B) for the determination of eztimibe in bulk drug and pharmaceutical formulations (tablets) have been described. Method A and B are based on the redox/complex formation reaction of drug with 1,10-phenanthroline and hexacyano-ferrate(III) in presence of ferric chloride to form coloured chromogens exhibitingλmaxat 510 and 740 nm respectively. The results of analysis for the two methods have been validated statistically and by recovery studies. The results are compared with those obtained using UV spectrophotometric method in alcohol at 231.7 nm.

scholarly journals Development of Analytical Profile of Lamotrigine and its API Formulation

2021 ◽  
pp. 111-114
Author(s):  
VISHAL CHAUDHARY ◽  
VASUNDHARA SAXENA
Keyword(s):  
Spectrophotometric Method ◽  
Quantitative Estimation ◽  
Pharmaceutical Formulations ◽  
Hplc Method ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Rp Hplc ◽  
System Suitability ◽  
Bulk Drug

Objective: The objective of this review is to put a light on the development of lamotrigine and its active pharmaceutical ingredients formulation with proper demonstration. Method: In the present work, one of the most imperative spectrophotometric method which is RP-HPLC method has been developed for the quantitative estimation of lamotrigine in bulk and pharmaceutical formulations. UV spectrophotometric method which involves the determination of Lamotrigine in bulk and in bulk drug and pharmaceutical formulation has maximum absorption at 307.5nm in methanol. It obeys Beer’s and Lambert’s law in the concentration range of 5-45 µg/ml. A rapid and sensitive RP- HPLC Method with UV detection (270 nm) for routine analysis of Lamotrigine formulation was developed. Chromatography was performed with mobile phase containing a mixture of methanol and Phosphate buffer (65:35v/v) with flow rate 1.0 ml/min. In the range of 20-100 µg/ml, the linearity of lamotrigine shows a correlation co-efficient of 0.9998. The proposed method was validated by determining sensitivity and system suitability parameters.

Spectrophotometric Determination of Isocarboxazid Bulk Drug and Tablets by Reaction with/7-Dimethylaminocinnamaldehyde

1988 ◽  
Vol 71 (6) ◽  
pp. 1134-1136
Author(s):  
Michael E El-Kommos
Keyword(s):  
Regression Analysis ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Trichloroacetic Acid ◽  
Excellent Correlation ◽  
Electrophilic Attack ◽  
Reagent Ratio ◽  
Bulk Drug ◽  
Methanolic Medium

Abstract A Spectrophotometric Method Is Described For The Determination Of Isocarboxazid. The Method Is Based On The Reaction Of The Drug With p-Dimethylaminocinnamaldehyde In The Presence Of Trichloroacetic Acid In A Methanolic Medium To Produce A Very Intense Red Chromophore (ℷmax = 500 Nm, Emax= 1.05 X 105). The Reaction Is Proposed To Proceed Via Electrophilic Attack At The C-4 Position Of The Isoxazole Nucleus. Job's Plot Indicated A 1:1 Drug-To-Reagent Ratio. Regression Analysis Of Beer's Plot Showed Excellent Correlation (R = 0.9996) In The Concentration Range 0.25-2.10 Fig Isocarboxazid/Ml. The Developed Color Is Stable For At Least 12 H. Results Of Analyses Of Bulk Drug And Tablets By The Proposed Method Are Comparable To Those For Usp Xxi Methods.

scholarly journals Spectrophotometric Determination of Palladium(II) Ions Using a New Reagent: 4-(N’-(4-Imino-2-oxo-thiazolidine-5-ylidene)-hydrazino)-benzoic Acid (p-ITYBA)

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Oleksandr S. Tymoshuk ◽  
Orest S. Fedyshyn ◽  
Lesia V. Oleksiv ◽  
Petro V. Rydchuk ◽  
Vasyl S. Matiychuk
Keyword(s):  
Detection Limit ◽  
Complex Formation ◽  
Benzoic Acid ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Water Medium ◽  
Analytical Reagent ◽  
Optimal Ph

The simple, rapid spectrophotometric method for palladium(II) ions determination using a new analytical reagent is described. The interaction of Pd(II) ions with a reagent, of the class of azolidones, 4-(N′-(4-imino-2-oxo-thiazolidine-5-ylidene)-hydrazino)-benzoic acid, in water medium results in the formation of a complex. The Pd(II)-p-ITYBA complex shows maximum absorbance at a wavelength of 450 nm. The molar absorptivity is 4.30 × 103 L·mol−1·cm−1. The optimal pH for complex formation is 7.0. The developed method has a wide linearity range of 0.64–10.64 µg·mL−1 for Pd(II). The detection limit is 0.23 µg·mL−1. It was found that Co(II), Ni(II), Zn(II), Fe(III), Cu(II), Al(III), and many anions do not interfere with the Pd(II) determination. The proposed method was tested in the analysis of model solutions and successfully applied for the determination of palladium in catalyst. The obtained results show that this method can be used for serial determinations of palladium in various objects.

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