Optical Coherence Tomography Findings of Retinal Folds in Nanophthalmos

Aim. To report the optical coherence tomography (OCT) findings in three members of the same family with nanophthalmos associated with elevated papillomacular retinal fold.Methods. Complete ophthalmic examination as well as ultrasonography and OCT was performed in all patients.Results. Axial lengths ranged from 16.75 mm to 17.48 mm and refractive errors ranged from +17.50 D to +20.50 D. Main fundus findings were the hyperopic crowded, cupless optic disc, and retinal fold through papillomacular region. Macular OCT scans revealed retinal fold with normal retinal pigment epithelium and choriocapillaris.Interpretation. It is presumed that the retinal folds in nanophthalmos result from a redundancy of the retinal layer caused by retarded growth of the scleral, choroidal, and retinal pigment epithelial layers. The anatomic information provided by the current study is consistent with this thesis.

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Retinal pigment epithelial detachment associated with retinal pigment epithelium thinning revealed by optical coherence tomography

Japanese Journal of Ophthalmology ◽

10.1007/s10384-015-0391-3 ◽

2015 ◽

Vol 59 (5) ◽

pp. 305-311 ◽

Cited By ~ 2

Author(s):

Satoko Notani ◽

Ryusaburo Mori ◽

Mitsuko Yuzawa ◽

Akiyuki Kawamura

Keyword(s):

Optical Coherence Tomography ◽

Retinal Pigment Epithelium ◽

Retinal Pigment Epithelial ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Pigment Epithelial Detachment ◽

Optical Coherence ◽

Retinal Pigment Epithelial Detachment ◽

Pigment Epithelial

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A Level Set Method with Region-Scalable Fitting Energy for Retinal Layer Segmentation in Spectral-Domain Optical Coherence Tomography Images

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2020.2905 ◽

2020 ◽

Vol 10 (2) ◽

pp. 326-335

Author(s):

Liming Liang ◽

Xiaoqi Sheng ◽

Bowen Liu ◽

Zhimin Lan

Keyword(s):

Optical Coherence Tomography ◽

Level Set ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Spectral Domain ◽

Retinal Layer ◽

Optical Coherence ◽

Retinal Layers ◽

Layer Segmentation ◽

Sd Oct

Retinal layer segmentation of spectral-domain optical coherence tomography images plays an important role during diagnosis and analysis of ophthalmic diseases. In this paper, a novel variational level set framework with region-scalable fitting energy is proposed for automated retinal layer segmentation in SD-OCT. To the best of our knowledge, it is the first time that level set based method succeeds in ten retinal layers segmentation. The proposed framework consists of three steps. First, an anisotropic nonlinear diffusion filter is applied for speckle noise reduction and ROI contrast enhancement. Second, Canny edge detectors are used to extract initial layers: nerve fiber layer, connecting cilia and retinal pigment epithelium. Finally, the rest retinal layers are segmented by means of level set model combined with prior knowledge of retinal thickness and morphology, for which the energy function consists of region-scalable fitting energy data term, area constraint term, regularization term and length penalty term. The proposed method was tested on 50 retinal SD-OCT B-scans from 50 normal subjects. The overall unsigned border position error is 5.92 ± 4.72 μm. The result showed that data terms with border weight terms can keep layer segmentation results in strong border while retaining its fitting capability in weak border. The proposed method achieves better segmentation result than other active contour models.

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Real-time Fully Automated Internal Layer Segmentation of Human Retina in Optical Coherence Tomography Images

International Journal of Engineering and Advanced Technology - Regular Issue ◽

10.35940/ijeat.c5632.029320 ◽

2020 ◽

Vol 9 (3) ◽

pp. 1951-1957

Keyword(s):

Optical Coherence Tomography ◽

Real Time ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Intensity Variation ◽

Frame Rate ◽

Retinal Layer ◽

Optical Coherence ◽

Retinal Layers ◽

Layer Segmentation

In the field of ophthalmology, optical coherence tomography (OCT) has proven to be a powerful imaging technique when it comes to diagnosing various eye-related diseases. This research article introduces a real-time automatic retinal layer segmentation algorithm based on intensity variation in the OCT images. The built algorithm is capable of detecting internal retinal layers like the internal limiting membrane (ILM), the retinal pigment epithelium (RPE) and the retinal nerve fiber layer (RNFL) with micrometer level precision, the algorithm uses openMP for parallelized computation for real-time visualization of the segmented retinal layers. The total execution time of the algorithm was evaluated using various image sizes and compared with the OCT frame rate to demonstrate the efficiency of real-time segmentation.

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Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Pharmaceutics ◽

10.3390/pharmaceutics13020217 ◽

2021 ◽

Vol 13 (2) ◽

pp. 217

Author(s):

Maria Jesus Rodrigo ◽

Amaya Pérez del Palomar ◽

Alberto Montolío ◽

Silvia Mendez-Martinez ◽

Manuel Subias ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Relative Intensity ◽

Therapeutic Option ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Aggregate Size ◽

Daily Practice ◽

Optical Coherence ◽

Non Invasive ◽

Invasive Method

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

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