The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
2011 ◽
Vol 2011
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pp. 1-6
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Keyword(s):
Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored. The role of inteleukin-6 classical and trans signalling pathways in SSc relevant phenomena such as chronic inflammation, autoimmunity, endothelial cell dysfunction, and fibrogenesis is discussed. The existing evidence that interventions designed to block interleukin-6 signalling are of therapeutic relevance in SSc is evaluated.
Keyword(s):
2016 ◽
Vol 6
(2)
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pp. 130-133
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2015 ◽
Vol 35
(4)
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pp. 1103-1108
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Keyword(s):
2018 ◽
Vol 77
(11)
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pp. 1665-1674
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Keyword(s):