scholarly journals Asymptomatic Malaria Correlates with Anaemia in Pregnant Women at Ouagadougou, Burkina Faso

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Zoenabo Douamba ◽  
Cyrille Bisseye ◽  
Florencia W. Djigma ◽  
Tegwinde R. Compaoré ◽  
Valérie Jean Telesphore Bazie ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Pregnant Women ◽  
Rapid Detection ◽  
Intermittent Preventive Treatment ◽  
Preventive Treatment ◽  
Asymptomatic Infection ◽  
Sub Saharan Africa ◽  
Asymptomatic Malaria ◽  
Low Levels ◽  
Sub Saharan

Sub-Saharan Africa records each year about thirty-two million pregnant women living in areas of high transmission ofPlasmodium falciparumcausing malaria. The aim of this study was to carve out the prevalence of asymptomatic malaria among pregnant women and to emphasize its influence on haematological markers. The prevalence ofPlasmodium falciparumasymptomatic infection among pregnant women was 30% and 24% with rapid detection test (RDT) and microscopy, respectively. The prevalence ofP. falciparumasymptomatic malaria was reduced among pregnant women using sulfadoxine-pyrimethamine's intermittent preventive treatment and 61% of them were anaemic. Anaemia was significantly more common in women infected withP. falciparumcompared with the uninfected pregnant women. Most of the women had normal levels of homocysteine and low levels of folate, respectively. Therefore, the systematic diagnosis of malaria should be introduced to pregnant women as a part of the antenatal care.

scholarly journals Asexual and sexual stages of Plasmodium falciparum in Nigerian pregnant women attending antenatal booking clinic

2010 ◽  
Vol 3 (3) ◽  
pp. 106-109 ◽  
Author(s):  
S T Balogun ◽  
F A Fehintola ◽  
O A Adeyanju ◽  
A A Adedeji
Keyword(s):  
Plasmodium Falciparum ◽  
Preterm Birth ◽  
Infant Mortality ◽  
Pregnant Women ◽  
Blood Meal ◽  
Sub Saharan Africa ◽  
Female Mosquito ◽  
Susceptibility To Infection ◽  
Sexual Stages ◽  
Sub Saharan

Susceptibility to infection by Plasmodium falciparum is increased in pregnant women. In sub-Saharan Africa, the consequences of maternal malaria include preterm birth, fetal growth restriction and increased infant mortality. Malaria transmission requires the circulation of viable gametocytes that can be ingested by the female mosquito taking a blood meal. This study was conducted to evaluate the presence of asexual and sexual stages of P. falciparum in pregnant women attending antenatal booking clinics in south-western Nigeria, an area hyper-endemic for malaria. Gametocyte carriage was about 13%, similar to that documented for children symptomatic for malaria in our area of study.

scholarly journals Prevalence and factors associated with carriage of Pfmdr1 polymorphisms among pregnant women receiving intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and artemether-lumefantrine for malaria treatment in Burkina Faso

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Hamtandi Magloire Natama ◽  
Rouamba Toussaint ◽  
Djamina Line Cerine Bazié ◽  
Sékou Samadoulougou ◽  
Maminata Coulibaly-Traoré ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Burkina Faso ◽  
Pregnant Women ◽  
Mutant Allele ◽  
Intermittent Preventive Treatment ◽  
Preventive Treatment ◽  
Dried Blood Spots ◽  
Nucleotide Polymorphisms ◽  
High Coverage ◽  
Factors Associated

Abstract Background Single nucleotide polymorphisms occurring in the Plasmodium falciparum multidrug resistant gene 1 (pfmdr1) are known to be associated with aminoquinoline resistance and, therefore, represent key P. falciparum markers for monitoring resistance both in susceptible groups (children under 5 years old and pregnant women) and in the general population. This study aimed to determine prevalence and factors associated with the carriage of pfmdr1 N86Y, Y184F and D1246Y polymorphisms among pregnant women in a setting of high malaria transmission in Burkina Faso. Methods Plasmodium falciparum isolates were collected at the first antenatal care visit (ANC-1) as well as at delivery from pregnant women participating in the COSMIC trial (NTC01941264), which assessed malaria preventive interventions during pregnancy in the Nanoro Health District. Here, pregnant women received intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and malaria infections and/or diseases were treated using artemether-lumefantrine (AL) during the trial. Parasite DNA was extracted from dried blood spots and the presence of pfmdr1 mutations at positions 86, 184 and 1246 was determined using nested PCR, followed by restriction fragment length polymorphism (RFLP) analysis. Results A prevalence of 13.2% (20/151) and 12.1% (14/116) of the pfmdr1 86Y mutant allele was found at ANC-1 and at delivery, respectively, while no mutant allele was observed for Y184F and D1246Y codons at both ANC-1 and at delivery. There were no significant factors associated with pfmdr1 86Y mutant allele carriage at ANC-1. However, malaria infections at delivery with a parasite density above the median (2237.2 (IQR: 613.5–11,425.7) parasites/µl) was associated with an increase risk of pfmdr1 86Y mutant allele carriage (AOR = 5.5 (95% CI  1.07–28.0); P = 0.04). In contrast, both three or more IPTp-SP doses (AOR = 0.25 (95% CI 0.07–0.92); P = 0.04) and one or more AL treatment (AOR = 0.25 (95% CI 0.07–0.89); P = 0.03) during pregnancy were associated with a significant reduce risk of pfmdr1 86Y mutant allele carriage at delivery. Conclusion These findings suggest that both high coverage of IPTp-SP and the use of AL for the treatment of malaria infection/disease during pregnancy select for pfmdr1 N86 wild-type allele at delivery.

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