scholarly journals Botulinum Toxin Injections for Simple Partial Motor Seizures Associated with Pain

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Edward C. Mader ◽  
Bruce J. Fisch ◽  
Nicole R. Villemarette-Pittman ◽  
Piotr W. Olejniczak ◽  
Michael E. Carey
Keyword(s):  
Botulinum Toxin ◽  
Pain Relief ◽  
Muscle Contraction ◽  
Seizure Frequency ◽  
Adjunctive Therapy ◽  
Seizure Control ◽  
Intractable Epilepsy ◽  
Seizure Severity ◽  
The Right ◽  
Botulinum Toxin Injections

Intractable epilepsy with painful partial motor seizures is a relatively rare and difficult disorder to treat. We evaluated the usefulness of botulinum toxin to reduce ictal pain. Two patients received two or four botulinum toxin (BTX) injections at one-to-two-month intervals. Patient 1 had painful seizures of the right arm and hand. Patient 2 had painful seizures involving the left foot and leg. Injections were discontinued after improved seizure control following resective surgery. Both patients received significant pain relief from the injections with analgesia lasting at least two months. Seizure severity was reduced, but seizure frequency and duration were unaffected. For these patients, BTX was effective in temporarily relieving pain associated with muscle contraction in simple partial motor seizures. Our findings do not support the hypothesis that modulation of motor end-organ feedback affects focal seizure generation. BTX is a safe and reversible treatment that should be considered as part of adjunctive therapy after failure to achieve control of painful partial motor seizures.

scholarly journals Occipital Neuralgia after Hair Transplantation and Its Treatment

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Jason Siefferman ◽  
Yury Khelemsky
Keyword(s):  
Physical Activity ◽  
Botulinum Toxin ◽  
Severe Pain ◽  
Complete Relief ◽  
Occipital Neuralgia ◽  
Pulsed Radiofrequency ◽  
Full Thickness ◽  
Hair Transplantation ◽  
The Right ◽  
Botulinum Toxin Injections

While undergoing full thickness tissue harvest from the posterior scalp, a 72-year-old man experienced immediate severe pain in the right occiput and was unable to complete the procedure. The pain was constant “sharp” and “shocking” with numbness in the distribution of the lesser occipital nerve, exacerbated by physical activity, and local anesthetic blocks provided temporary complete relief. After numerous treatments over several years, including oral analgesics, botulinum toxin injections, and acupuncture, proved ineffective, pulsed radiofrequency neuromodulation provided greater than 80% relief for 5 months.

Epileptic Adolescents and Ramadan Fasting: A Prospective Cohort Study

2020 ◽  
Author(s):  
Amira Hamed Darwish
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Seizure Frequency ◽  
Prospective Cohort ◽  
Seizure Control ◽  
Ramadan Fasting ◽  
Seizure Severity ◽  
Significant Difference ◽  
Epileptic Patients ◽  
Neurology Clinic

AbstractThe study aimed to evaluate the effect of Ramadan fasting on seizure control in epileptic adolescents. A prospective cohort study that included 56 epileptic patients aged 11 to 18 years. Patients were followed-up in the pediatric neurology clinic at Tanta University Children's Hospital during Ramadan 2019. Seizures frequency and severity, measured by Chalfont seizure severity scale, during Ramadan fasting were compared with those in the month before Ramadan. Before Ramadan, 43/56 patients were controlled and seizure free. Meanwhile, 13/56 patients were uncontrolled and had seizure frequency of one to six seizures in the month before Ramadan. There was no significant difference in seizure frequency during Ramadan compared with before Ramadan (p = 0.132), whereas seizure severity was significantly reduced during Ramadan (p = 0.028). Both seizure frequency and severity were significantly lower during Ramadan in uncontrolled epileptic patients compared with before Ramadan (p = 0.02 and 0.005). Ramadan fasting is safe in adolescents with epilepsy. Fasting is not a precipitating factor for seizures in epileptic adolescents, provided compliance to antiepileptic drugs, and could be beneficial for seizure control in uncontrolled epilepsy.

scholarly journals Dysembryoplastic Neuroepithelial Tumor: A Rare Brain Tumor with Excellent Seizure Control after Surgical Resection

2020 ◽  
Author(s):  
Rajnish Kumar Arora ◽  
Pranshu Bhargava ◽  
Poonam Arora ◽  
Prashant Joshi ◽  
Garga Basu ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Medial Temporal Lobe ◽  
Seizure Control ◽  
Intractable Epilepsy ◽  
Mass Effect ◽  
Sudden Onset ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Focal Neurological Deficit ◽  
Fluid Attenuated Inversion Recovery ◽  
The Right

Abstract Introduction Dysembryoplastic neuroepithelial tumor (DNET) is a rare cause of intractable epilepsy, which has excellent results in terms of seizure control after surgical resection. We present one such case, because of its rarity, to highlight the effect of tumor removal on seizure control, particularly DNET. Materials and Methods/Case Summary A 9-year-old male patient presented with sudden onset of partial seizures for the past 6 months. There were five episodes. In each episode, the patient engaged in irrelevant talk, followed by deviation of mouth to left and twitching movements. The episode lasted 5 minutes and there was no loss of consciousness. There was no aura or tongue bite, and in one of the episodes, the patient lost consciousness. There was no other significant positive history. On examination, the child was consciously alert, without focal neurological deficit or features of meningitis. There was no papilledema. The patient was on phenytoin sodium, phenobarbitone and clobazam. Magnetic resonance imaging (MRI) of brain was done with and without contrast. MRI revealed a lesion approximately 4.1 × 3.6 × 3.2 cm in the right medial temporal lobe. It was hypointense to brain on T1 and fluid-attenuated inversion recovery (FLAIR), and hyperintense on T2-weighted images. Diffusion restriction was present and there was minimal contrast uptake. There was no evidence of mass effect or midline shift After discussing the risks and benefits with parents, the patient underwent preanesthetic checkup, and was taken up for craniotomy and excision of tumor. Gross total excision was done. The child was started orally on day 1 postoperatively and ambulated. There were no further seizure episodes. The patient was continued on phenytoin and clobazam, and phenobarbitone was tapered gradually. At 6 months, the child was seizure-free. Conclusions DNET are rare tumors occurring early in life and presenting with intractable seizures. Surgical resection offers a good and safe chance for long-term seizure control.

Seizure frequency, patient-perceived seizure severity and the psychosocial consequences of intractable epilepsy

1991 ◽  
Vol 9 (3) ◽  
pp. 231-241 ◽  
Author(s):  
David F. Smith ◽  
Gus A. Baker ◽  
Michael Dewey ◽  
Ann Jacoby ◽  
David W. Chadwick
Keyword(s):  
Seizure Frequency ◽  
Intractable Epilepsy ◽  
Seizure Severity ◽  
Psychosocial Consequences

1710: Intra-Detrusor Botulinum Toxin Injections for Human Bladder Overactivity Decrease P2X3 but not PGP9.5 or Ache Expressing Suburothelial Innervation

2004 ◽  
Vol 171 (4S) ◽  
pp. 452-452 ◽  
Author(s):  
Apostolos Apostolidis ◽  
Roshni Popat ◽  
Yiangos Yiangou ◽  
Preston A. Baecker ◽  
Anthony Ford ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Human Bladder ◽  
Botulinum Toxin Injections

Dry Needling Can Be An Alternative Treatment for Hemifacial Spasm

2020 ◽  
Vol 6 (2) ◽  
pp. 20-28
Author(s):  
Selly Marisdina ◽  
Henry Sugiharto ◽  
A Pradian
Keyword(s):  
Botulinum Toxin ◽  
Hemifacial Spasm ◽  
Alternative Treatment ◽  
Epidemiological Data ◽  
Clinical Severity ◽  
Decompression Surgery ◽  
Dry Needling ◽  
Significant Difference ◽  
Microvascular Decompression Surgery ◽  
Botulinum Toxin Injections

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.

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