scholarly journals A Case Report of Spindle Cell (Sarcomatoid) Carcinoma of the Larynx

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Harry Boamah ◽  
Billy Ballard
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Early Stage ◽  
Sarcomatoid Carcinoma ◽  
Good Control ◽  
Spindle Cell Carcinoma ◽  
Good Prognosis

Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. His symptoms gradually improved, and he regained good control of his voice.

scholarly journals Sarcomatoid carcinoma a rare variant of squamous cell carcinoma of larynx: a case report

2017 ◽  
Vol 3 (3) ◽  
pp. 768
Author(s):  
Trilok C. Guleria ◽  
Shobha Mohindroo ◽  
Narender K. Mohindroo ◽  
Ramesh K. Azad
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Rare Variant ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Early Stage ◽  
Sarcomatoid Carcinoma ◽  
Spindle Cell Carcinoma ◽  
Good Prognosis

<p>Sarcomatoid (spindle cell) carcinoma is a rare variant of squamous cell carcinoma (SCC). It compromises of 2–3% of laryngeal cancers. Tumor arises from the oral cavity, tonsil, larynx and pharynx. Majority of these tumors are polypoid or pedunculated and tend to cause obstructive symptoms. These tumors are often detected at an early stage, removed by polypectomy during diagnosis and tend to have a very good prognosis. In this case report, 76 years male who presented with progressive hoarseness of his voice and pain in throat. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiotherapy. </p>

Simultaneous tumours of the larynx with the same histology: a case report and review of the literature

2005 ◽  
Vol 119 (3) ◽  
pp. 230-232
Author(s):  
Giancarlo Ottaviano ◽  
Gino Marioni ◽  
Rosario Marchese-Ragona ◽  
Filippo Marino ◽  
Alberto Staffieri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Rare Occurrence ◽  
Review Of The Literature

Synchronous laryngeal malignancies are extremely uncommon. To the best of our knowledge, only four cases of primary synchronous squamous cell carcinoma (SCC) of the larynx are available in the literature. We report the case of a 52-year-old patient with simultaneous spindle-cell carcinoma and SCC in situ of the larynx. The pathogenesis, treatment and prognosis of this rare occurrence have been discussed.

scholarly journals Spindle Cell Carcinomas of the Upper Aerodigestive Tract

2012 ◽  
Vol 27 (2) ◽  
pp. 37-38
Author(s):  
Jose M. Carnate
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
World Health ◽  
Invasive Squamous Cell Carcinoma ◽  
Cell Component ◽  
Spindle Cell Component

A 65-year-old male with a two-month history of cough and hoarseness underwent direct laryngoscopy which showed a 1.5 cm diameter polypoid glottic mass. A polypectomy was performed revealing spindle cell carcinoma.   The World Health Organization (2005) defines a spindle cell carcinoma as “a biphasic tumor composed of a squamous cell carcinoma, either in-situ and/or invasive, and a malignant spindle cell component with a mesenchymal appearance, but of epithelial origin.”1 Spindle cell carcinomas go by a variety of synonyms such as sarcomatoid carcinoma, spindle cell squamous carcinoma and carcinosarcoma.   The larynx is a preferred site of involvement where they often present as polypoid masses.1,3 Microscopic examination often shows predominance of the sarcomatoid, spindle-cell component, which can range from fairly bland, reactive-looking fibroblastic-proliferation-like processes, to cytologically malignant and mitotically active proliferations that mimic other spindle-cell sarcomas such as leiomyosarcoma, fibrosarcoma or malignant fibrous histiocytoma.1,2,3 (Figure 1, double arrows)  The squamous cell carcinoma component may be in the form of an overlying carcinoma-in-situ, or of a focal keratinizing invasive squamous cell carcinoma that requires multiple sections to disclose.1,2  (Figure 1, single arrow) Cytokeratin-reactivity in the spindle cells, which may be quite focal as in this case, points to their epithelial derivation.1,2,4 (Figure 2) Favorable prognostic findings include polypoid morphology and, like conventional laryngeal squamous cell carcinomas, a low-stage and a glottic site of origin. Reported 5-year survival rates range from 65 – 95%.1  

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

Early-Stage Supraglottic “In Situ” Squamous Cell Carcinoma of the Larynx Incidentally Detected by 18F-Fluorocholine PET/CT

2019 ◽  
Vol 44 (7) ◽  
pp. e435-e438
Author(s):  
Stefano Attilio Mangili ◽  
Nicola Rizzardi ◽  
Sonia Illuminati ◽  
Claudio Bnà ◽  
Giordano Savelli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Pet Ct ◽  
Carcinoma Of The Larynx

Clinical Analysis of Laryngeal Spindle Cell Carcinoma

ORL ◽  
2020 ◽  
Vol 82 (6) ◽  
pp. 310-317
Author(s):  
Le Chen ◽  
Qi Chen ◽  
Cai Li ◽  
Liang Zhou ◽  
Shuyi Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Propensity Score ◽  
Cell Carcinoma ◽  
Clinical Features ◽  
Squamous Cell ◽  
Treatment Strategy ◽  
Spindle Cell ◽  
Clinical Analysis ◽  
Spindle Cell Carcinoma ◽  
Seer Database

<b><i>Aims:</i></b> To investigate the clinical features, treatment, and outcomes of laryngeal spindle cell carcinoma (SpCC). <b><i>Methods:</i></b> Between 2005 and 2014, patients from our hospital with SpCC of the larynx were retrospectively analyzed alongside patient data from the SEER database of America. <b><i>Results:</i></b> A total of 11 patients with SpCC of the larynx were diagnosed and underwent surgery in our hospital. All patients were male and all tumors were located in the glottis. The 3- and 5-year OS rates were both 54.5%. In the SEER database, 148 patients were diagnosed with SpCC of the larynx. The 3- and 5-year OS rates were 72.8 and 63.2%, respectively. According to the comparison of propensity score-matched analysis, the OS was longer in squamous cell carcinoma (SCC) of the larynx (<i>p</i> &#x3c; 0.0001). <b><i>Conclusion:</i></b> SpCC of the larynx is rare and typically originates in the glottis. Its prognosis is worse than that of laryngeal SCC, and surgery is a reasonable treatment strategy.

Sign in / Sign up

Export Citation Format

Share Document