scholarly journals Lack of Association betweenCLEC5AGene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ya-Ling Yang ◽  
Wei-Pin Chang ◽  
Yu-Wen Hsu ◽  
Wei-Chiao Chen ◽  
Hong-Ren Yu ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Single Nucleotide Polymorphisms ◽  
Treatment Response ◽  
Intravenous Immunoglobulin ◽  
Coronary Artery Lesion ◽  
Nucleotide Polymorphisms ◽  
Lesion Formation ◽  
Single Nucleotide ◽  
Immunoglobulin Treatment

Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD.Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) ofCLEC5A(rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test.Results. No significant associations were noted between the genotypes and allele frequency of the 4CLEC5AtSNPs between controls and patients. In the patients, polymorphisms ofCLEC5Ashowed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response.Conclusions. This study showed for the first time that polymorphisms ofCLEC5Aare not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.

scholarly journals HMGB1 gene polymorphism is associated with coronary artery lesions and intravenous immunoglobulin resistance in Kawasaki disease

Rheumatology ◽  
2018 ◽  
Vol 58 (5) ◽  
pp. 770-775 ◽  
Author(s):  
Jong Gyun Ahn ◽  
Yoonsun Bae ◽  
Dongjik Shin ◽  
Jiho Nam ◽  
Kyu Yeun Kim ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Single Nucleotide Polymorphisms ◽  
Odds Ratio ◽  
Ivig Treatment ◽  
Nucleotide Polymorphisms ◽  
Coronary Artery Lesions ◽  
Hmgb1 Level ◽  
Single Nucleotide ◽  
Ivig Resistance

Abstract Objectives Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports of elevated serum high mobility group box 1 (HMGB1) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD. We investigated the association between the polymorphisms of the HMGB1 gene, KD susceptibility, coronary artery lesions, and KD response to IVIG treatment. Methods Whole genome sequencing of the HMGB1 gene was performed to identify causative variants. Two tagging single nucleotide polymorphisms of the HMGB1 gene were selected using linkage disequilibrium analysis. The tagging single nucleotide polymorphisms were genotyped using the TaqMan Allelic Discrimination assay in a total of 468 subjects (265 KD patients and 203 controls). Results The HMGB1 single nucleotide polymorphisms were not associated with KD susceptibility. However, in KD patients, there was a significant association of rs1412125 with coronary artery lesions formation in the recessive model (GG vs AA + GA: odds ratio = 4.98, 95% CI = 1.69–14.66, P = 0.005). In addition, rs1412125 was associated with IVIG resistance in the recessive (GG vs AA + GA: odds ratio = 4.11, 95% CI = 1.38–12.23, P = 0.017) and allelic models (G vs A: odds ratio = 1.80, 95% CI = 1.06–3.06, P = 0.027). Conclusion The rs1412125 in HMGB1 might be a risk factor for the development of coronary artery lesions and IVIG resistance in KD patients.

Association of MnSOD gene polymorphism with susceptibility to Kawasaki disease in Chinese children

2020 ◽  
pp. 1-7
Author(s):  
Jiping Wu ◽  
Meng Yu ◽  
Lihua Huang ◽  
Yujie Qian ◽  
Min Kong ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Human Body ◽  
Gene Polymorphisms ◽  
Coronary Artery Lesion ◽  
Nucleotide Polymorphisms ◽  
Coronary Artery Lesions ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Mnsod Gene

Abstract Background: Kawasaki disease is a type of acute febrile rash disease that is common in children and is characterised by primary lesions of systemic middle and small vasculitis, which can lead to coronary artery lesions. Manganese superoxide dismutase (MnSOD), one of the most important antioxidases in the human body, plays a key role in maintaining the balance of free radicals in the human body. Two single-nucleotide polymorphisms (SNPS) (rs4880 and rs5746136) in the MnSOD gene were related to oxidative stress disease. The purpose of this study is to explore the possible relationship between MnSOD gene polymorphisms and Kawasaki disease susceptibility. Methods: This study included 100 Kawasaki disease children and 102 healthy children. Two single-nucleotide polymorphisms (rs4880 and rs5746136) were detected by polymerase chain reaction sequence-based typing. Results: There was a significant difference in both the genotype frequency (χ2 = 10.805, p = 0.005) and the allele frequency (χ2 = 7.948, p = 0.005) of rs5746136 between the Kawasaki disease group and the control group. Children with the A allele had a 0.558 times lower risk of Kawasaki disease than those without the A allele (χ2 = 7.948, p = 0.005, odds ratio = 0.558, 95% confidence interval = 0.371–0.838). There was no significant difference in the genotype and gene frequencies of rs5746136 between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesion groups (p > 0.05), and there was no significant difference in the rs4880 genotype and allele frequencies between the Kawasaki disease and healthy control groups or between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesions groups (p > 0.05). Conclusion: This study provides evidence supporting an association between MnSOD gene polymorphisms and susceptibility to Kawasaki disease. The genotype AA and the allele A of the MnSOD gene locus rs5746136 were risk factors for Kawasaki disease.

scholarly journals FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response

2013 ◽  
Vol 23 (9) ◽  
pp. 455-462 ◽  
Author(s):  
Robert Makowsky ◽  
Howard W. Wiener ◽  
Travis S. Ptacek ◽  
Miriam Silva ◽  
Aditi Shendre ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Treatment Response ◽  
Intravenous Immunoglobulin ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Immunoglobulin Treatment

The relationship betweenInterleukin-27gene polymorphisms and Kawasaki disease in a population of Chinese children

2018 ◽  
Vol 28 (9) ◽  
pp. 1123-1128 ◽  
Author(s):  
Feifei Si ◽  
Yao Wu ◽  
Xianmin Wang ◽  
Fang Gao ◽  
Dan Yang ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Single Nucleotide Polymorphisms ◽  
Developed Countries ◽  
Chinese Children ◽  
Interleukin 12 ◽  
Healthy Children ◽  
Arterial Aneurysm ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Interleukin 27

AbstractBackgroundKawasaki disease is the leading cause of acquired heart disease in children from developed countries. The Interleukin-6/ Interleukin-12 cytokine family has many members, including the paradoxical anti- and pro-inflammatory Interleukin-27. Recent studies have demonstrated that Interleukin-27 plays a role in immune diseases. Given this, we sought to evaluate the association betweenInterleukin-27genetic polymorphisms and Kawasaki disease in Chinese children.Methods and resultsInterleukin-27 was genotyped in 100 Kawasaki disease children and 98 healthy children (controls), resulting in the direct sequencing of eight Single-nucleotide Polymorphisms: rs17855750, rs40837, rs26528, rs428253, rs4740, rs4905, rs153109, and rs181206). There were no significant differences in Interleukin-27 genotypes between Kawasaki disease and control groups. Of the eight Single-nucleotide Polymorphisms, there was a significant increase in the risk of Kawasaki disease with coronary arterial lesions in children with the rs17855750 (T>G), rs40837 (A>G), rs4740 (G>A), rs4905 (A>G), rs153109 (T>C), and rs26528 (A>G) Single-nucleotide Polymorphisms. This was particularly true for rs17855750 (T>G), which had a greater frequency in Kawasaki disease children with coronary arterial aneurysm.ConclusionThese findings may be used as risk factors when assessing a child’s likelihood of developing Kawasaki disease, as well as for the development of future therapeutic treatments for Kawasaki disease.

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