Esophageal Capsule Endoscopy for Screening Esophageal Varices among Japanese Patients with Liver Cirrhosis

Purpose. Although esophageal capsule endoscopy (ECE) is reportedly useful in the diagnosis of esophageal varices (EV), few reports have described the benefits of this technique in Asian countries. The present paper evaluates the usefulness of ECE for diagnosing EV in Japanese patients with cirrhosis.Methods. We examined 29 patients with cirrhosis (20 males and 9 females; mean age 60 years; Child-Pugh classification A/B/C; 14/14/1) using ECE followed by esophagogastroduodenoscopy (EGD). High-risk EV were defined as F2 and/or RC2 and above.Results. The sensitivity and specificity of ECE for the diagnosis of high-risk EV were 92% and 80%, respectively.Conclusions. The findings showed that ECE is a highly sensitive method of diagnosing high-risk EV that requires endoscopic or pharmacological therapy. Thus, ECE might be a useful method for the screening and followup of EV in patients with cirrhosis.

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M1123 The Accuracy and Safety of Esophageal Capsule Endoscopy for the Detection of Esophageal Varices: A Meta-Analysis

Gastroenterology ◽

10.1016/s0016-5085(08)61599-1 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-343

Author(s):

Dimple Raina ◽

Thad Wilkins ◽

Sherman Chamberlain ◽

Mark Ebell

Keyword(s):

Capsule Endoscopy ◽

Esophageal Varices ◽

Meta Analysis ◽

Esophageal Capsule

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Esophageal Capsule Endoscopy (PillCam ESO) Is Comparable to Traditional Endoscopy for Detection of Esophageal Varices-An International Multi-Center Trial

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2007.03.017 ◽

2007 ◽

Vol 65 (5) ◽

pp. AB107 ◽

Cited By ~ 3

Author(s):

Roberto De Franchis ◽

Glenn M. Eisen ◽

Abraham R. Eliakim ◽

Amandeep Sahota ◽

Ignacio Fernandez-Urien ◽

...

Keyword(s):

Capsule Endoscopy ◽

Esophageal Varices ◽

Esophageal Capsule

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Diagnostic Accuracy of Non-invasive Laboratory-Based Fibrosis Scores in Predicting the Presence of Esophageal Varices in Liver Cirrhosis

Journal of Advances in Internal Medicine ◽

10.3126/jaim.v9i2.32814 ◽

2020 ◽

Vol 9 (2) ◽

pp. 54-59

Author(s):

Rajesh Pandey ◽

Rahul Pathak ◽

Arun Gnawali ◽

Prem Krishna Khadga ◽

Sashi Sharma ◽

...

Keyword(s):

Liver Cirrhosis ◽

High Risk ◽

Diagnostic Accuracy ◽

Receiver Operating Characteristic ◽

Esophageal Varices ◽

Operating Characteristic ◽

Cutoff Value ◽

Non Invasive ◽

Apri Score ◽

Receiver Operating

Introduction: Non-invasive assessment of esophageal varices (EVs) may reduce endoscopic burden and cost. This study aimed to evaluate the diagnostic accuracy of non-invasive fibrosis scores (AAR, APRI, FIB-4, King and Lok scores) for the prediction of varices in liver cirrhosis. Methods: This prospective study included 100 liver cirrhosis patients who underwent screening endoscopy for EVs. AAR, APRI, FIB-4, King and Lok scores were assessed. The receiver operating characteristic curves (ROC) were plotted to measure and compare the performance of each score for predicting EVs and to obtain the corresponding optimal prediction value. Results: Of the 100 patients, 70 were males and 30 were females with a mean age of 54.05±11.58 years. Esophageal varices were found in 77 patients out of which 58.44% were high-risk varices. Platelet count and non-invasive fibrosis scores APRI, FIB-4, Lok and King were able to discriminate patients with and without varices. Using area under receiver operating characteristic curve (AUROC), these scores were found to have low to moderate diagnostic accuracy for the presence of EVs and high-risk EVs, where the APRI score had the highest AUROC (0.77 and 0.70) respectively. At a cutoff value > 1.4, APRI score had 90.9% sensitivity, 60.9% specificity and 84 % diagnostic accuracy in predicting the presence of varices, while it had 84.4% sensitivity, 45.5% specificity and 63% diagnostic accuracy in predicting the presence of highrisk varices, at a cutoff value > 2.02. Conclusion: APRI, AAR, FIB-4, King, and Lok scores had low to moderate diagnostic accuracy in predicting the presence of varices in liver cirrhosis. The APRI score can help select a patient for the endoscopy but cannot replace endoscopy for esophageal varices screening.

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Detachable string magnetically controlled capsule endoscopy for complete viewing of the esophagus and stomach

Endoscopy ◽

10.1055/a-0856-6845 ◽

2019 ◽

Vol 51 (04) ◽

pp. 360-364 ◽

Cited By ~ 6

Author(s):

Yi-Zhi Chen ◽

Jun Pan ◽

Yuan-Yuan Luo ◽

Xi Jiang ◽

Wen-Bin Zou ◽

...

Keyword(s):

Pilot Study ◽

Adverse Events ◽

Diagnostic Accuracy ◽

Reflux Esophagitis ◽

Capsule Endoscopy ◽

Esophageal Varices ◽

Esophageal Disease ◽

Technical Success ◽

Novel Technique ◽

Esophageal Capsule

Abstract Background Esophageal capsule endoscopy is reported to be insufficiently accurate to replace esophagogastroduodenoscopy (EGD) because the passage of the capsule through the esophagus is passive and precludes a thorough investigation. We developed a modified capsule endoscopy technique, called detachable string magnetically controlled capsule endoscopy (DS-MCE), and performed a pilot study to assess the feasibility and safety of this novel technique. Methods 4 healthy volunteers and 21 patients with suspected esophageal disease first underwent DS-MCE followed by EGD within 1 week. Outcomes included technical success of DS-MCE, adverse events, discomfort, and diagnostic accuracy. Results DS-MCE was successfully carried out in all 25 participants. No adverse events were observed. Mean overall discomfort score during DS-MCE was 0.96 (range 0 – 3). DS-MCE diagnoses were in accordance with EGD in all 25 participants. The per-patient sensitivity of DS-MCE for esophageal disease detection was 100 %. The accuracy of DS-MCE for grading esophageal varices and reflux esophagitis were 66.7 % and 100 %, respectively. Conclusions DS-MCE was a feasible, safe, and well-tolerated method for viewing the esophagus and proceeding with gastric examination after string detachment.

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