scholarly journals Nonislet Cell Tumor Hypoglycemia

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Johnson Thomas ◽  
Salini C. Kumar
Keyword(s):  
Glucose Utilization ◽  
Cell Tumor ◽  
Gi Tract ◽  
Normal Range ◽  
Mesenchymal Tumors ◽  
Hypoglycemia Unawareness ◽  
Factor Ii ◽  
Carcinoma Of Esophagus ◽  
Poorly Differentiated ◽  
Tumor Hypoglycemia

Nonislet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia. It is characterized by increased glucose utilization by tissues mediated by a tumor resulting in hypoglycemia. NICTH is usually seen in large mesenchymal tumors including tumors involving the GI tract. Here we will discuss a case, its pathophysiology, and recent advances in the management of NICTH. Our patient was diagnosed with poorly differentiated squamous cell carcinoma of esophagus. He continued to be hypoglycemic even after starting continuous tube feeds and D5W. General workup for hypoglycemia was negative and insulin-like growth factor II (IGF II) was in the normal range. Hypoglycemia secondary to “big” IGF II was considered, and patient was started on steroids. His hypoglycemia resolved within a day of treatment with steroids. Initially patient had hypoglycemia unawareness, which he regained after maintaining euglycemia for 48 hours.

scholarly journals A Rapid Method for Analyzing Serum Pro-Insulin-Like Growth Factor-II in Patients with Non-Islet Cell Tumor Hypoglycemia

2005 ◽  
Vol 90 (7) ◽  
pp. 3819-3823 ◽  
Author(s):  
Farideh Miraki-Moud ◽  
Ashley B. Grossman ◽  
Michael Besser ◽  
John P. Monson ◽  
Cecilia Camacho-Hübner
Keyword(s):  
Growth Factor ◽  
Rapid Method ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

scholarly journals Characterization of Insulin-Like Growth Factor II(IGF-II) and IGF Binding Proteins in Patients with Non-Islet-Cell Tumor Hypoglycemia.

1993 ◽  
Vol 40 (1) ◽  
pp. 111-119 ◽  
Author(s):  
IZUMI FUKUDA ◽  
NAOMI HIZUKA ◽  
KAZUE TAKANO ◽  
KUMIKO ASAKAWA-YASUMOTO ◽  
KAZUO SHIZUME ◽  
...  
Keyword(s):  
Growth Factor ◽  
Islet Cell ◽  
Binding Proteins ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Igf Binding Proteins ◽  
Factor Ii ◽  
Igf Binding ◽  
Tumor Hypoglycemia

scholarly journals Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Se Won Kim ◽  
Seung-Eun Lee ◽  
Young Lyun Oh ◽  
Seokhwi Kim ◽  
Sun Hee Park ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Level ◽  
Paraneoplastic Syndrome ◽  
Adrenocortical Carcinoma ◽  
Exceptional Case ◽  
Cell Tumor ◽  
Factor Ii ◽  
Igf I ◽  
Tumor Hypoglycemia ◽  
Recurrent Hypoglycemia

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient’s serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

scholarly journals Splenic cord capillary hemangioma with non-islet cell tumor hypoglycemia: a case report

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Tatsuaki Daimon ◽  
Takeo Kosaka ◽  
Minoru Horinaga ◽  
Junichi Saito ◽  
Yoshito Ueyama ◽  
...  
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumor ◽  
Vascular Lesion ◽  
Capillary Hemangioma ◽  
Cell Tumor ◽  
Splenic Parenchyma ◽  
Factor Ii ◽  
Total Splenectomy ◽  
Tumor Hypoglycemia ◽  
Enhanced Computed Tomography

Abstract Background Splenic cord capillary hemangioma is a rare benign vascular lesion classified as a splenic hamartoma. On the other hand, non-islet cell tumor hypoglycemia (NICTH) is one of the rare causes of spontaneous hypoglycemia and is considered to be one of the paraneoplastic syndromes. To the best of our knowledge, this is the first reported case of a splenic cord capillary hemangioma with NICTH. Case presentation A 25-year-old male was referred to our hospital with hypoglycemia. Except for his low blood sugar, there were no abnormal findings from laboratory tests, which included an endocrinological examination. Enhanced computed tomography confirmed the presence of a solid mass measuring about 6 cm in the retroperitoneum, and a tumorectomy was performed. During this operation, it became clear that the tumor turned out to be a splenic parenchyma, and as a result, a total splenectomy was performed. Microscopically, we diagnosed this as a cord capillary hemangioma, and through immunohistochemistry, we found that some tumor cells were positive for insulin-like growth factor -II. Fortunately, the hypoglycemia-related symptoms disappeared after surgical resection was performed. The patient is still alive and well without evidence of local tumor recurrence 15 years after the operation. Conclusions Splenic cord capillary hemangioma, one of the types of splenic hamartomas, is a very rare benign vascular lesion and might be associated with hypoglycemia thought to be NICTH.

A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II

2010 ◽  
Vol 60 (8) ◽  
pp. 595-597 ◽  
Author(s):  
Hiroshi Maruyama ◽  
Mitsutoshi Tatsumi ◽  
Hitoshi Kitayama ◽  
Yasunori Enomoto ◽  
Hiroki Kuniyasu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

scholarly journals Serum Insulin-Like Growth Factor II in 44 Patients with Non-Islet Cell Tumor Hypoglycemia

1998 ◽  
Vol 45 (Suppl) ◽  
pp. S61-S65 ◽  
Author(s):  
NAOMI HIZUKA ◽  
IZUMI FUKUDA ◽  
KAZUE TAKANO ◽  
YUMIKO OKUBO ◽  
KUMIKO ASAKAWA-YASUMOTO ◽  
...  
Keyword(s):  
Growth Factor ◽  
Islet Cell ◽  
Serum Insulin ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

scholarly journals Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor

2020 ◽  
Author(s):  
Maurizio Alletto ◽  
Antonio Burgio ◽  
Giovanni Fulco ◽  
Giulio Geraci ◽  
Concetta Groppuso ◽  
...  
Keyword(s):  
Growth Factor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Growth Factor Receptor ◽  
Cell Tumor ◽  
Tyrosine Kinase Receptors ◽  
Β Cells ◽  
Mesenchymal Tumors ◽  
Metastatic Gist ◽  
Tumor Hypoglycemia

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GIST derive from mutations in tyrosine kinase receptors (KIT) or platelet-derived growth factor receptor-α (PDGFRA). GISTs are rarely associated with paraneoplastic hypoglycemia caused by non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST.

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