scholarly journals Limbal Pseudoepitheliomatous Hyperplasia Mimicking Ocular Surface Squamous Neoplasia in Palpebral Vernal Keratoconjunctivitis

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Chintan Malhotra ◽  
Arun K. Jain ◽  
Bikram Thapa
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Malignant Transformation ◽  
Ocular Surface ◽  
Dense Plasma ◽  
Vernal Keratoconjunctivitis ◽  
Excision Biopsy ◽  
Ocular Surface Squamous Neoplasia ◽  
Pseudoepitheliomatous Hyperplasia ◽  
Uncommon Presentation

Purpose. Pseudoepitheliomatous hyperplasia at the limbus can mimic an ocular surface squamous neoplasia. It is an uncommon manifestation of vernal keratoconjunctivitis and has been reported previously in limbal VKC. It, however, has not been reported as a manifestation in the palpebral form of the disease and needs to be kept in the differential diagnosis of a limbal mass lesion in vernal keratoconjunctivitis.Case Report. We report the case of a 24 year old male patient having palpebral VKC and presenting with a papillomatous limbal mass with focal areas of keratinization mimicking an ocular surface squamous neoplasia. An excision biopsy was performed, and the specimen sent for histopathologywhich revealed features of pseudoepitheliomatous hyperplasia with no evidence of dysplasia or malignant transformation. The subepithelium revealed a dense plasma-rich inflammation.Discussion. We report this relatively uncommon presentation of limbal pseudoepitheliomatous hyperplasia mimicking an ocular surface squamous neoplasia in palpebral vernal keratoconjunctivitis. Wide excision as is required for an ocular surface neoplasia may thus be avoided if this entity is recognized in vernal keratoconjunctivitis.

scholarly journals Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Noriyuki Watanabe ◽  
Eiichi Ishikawa ◽  
Hidehiro Kohzuki ◽  
Noriaki Sakamoto ◽  
Alexander Zaboronok ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Malignant Transformation ◽  
Pleomorphic Xanthoastrocytoma

Combined treatment modality for invasive ocular surface squamous neoplasia in an HIV positive patient: a case report

2012 ◽  
Vol 2 (1) ◽  
pp. 25 ◽  
Author(s):  
Shubhangi Nigwekar ◽  
Tanvi Haldipurkar ◽  
Somen Misra ◽  
Bharati Baviskar ◽  
Megha Bhosale ◽  
...  
Keyword(s):  
Case Report ◽  
Ocular Surface ◽  
Treatment Modality ◽  
Combined Treatment ◽  
Positive Patient ◽  
Hiv Positive ◽  
Ocular Surface Squamous Neoplasia

scholarly journals Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
A. D’Introno ◽  
A. Perrone ◽  
A. Schilardi ◽  
A. Gentile ◽  
C. Sabbà ◽  
...  
Keyword(s):  
Weight Loss ◽  
Differential Diagnosis ◽  
Case Report ◽  
Excision Biopsy ◽  
Review Of The Literature ◽  
Old Patients ◽  
Italian Woman ◽  
Night Sweats ◽  
Young Subjects ◽  
Asian People

Kikuchi–Fujimoto disease (KFD) is a rare, benign, generally self-limiting disease that has higher prevalence in Asian people with a few cases reported in European countries. It generally affects young subjects under 40 years of age and is characterized by regional lymphadenopathy. Here, we present a case of a 66-year-old Italian woman who was extensively examined for right unilateral laterocervical lymph nodes associated with fever, night sweats, fatigue, and weight loss. She was diagnosed as having the KFD only after an excision biopsy of the largest laterocervical lymph node and was then managed symptomatically with NSAIDs. We also made a review of the literature for better awareness of the disease among physicians especially in those countries, like Italy, where the disease is not prevalent and may be frequently misdiagnosed. In fact, to our best knowledge, only seven Italian cases of KFD have been published in the last 15 years with patients being younger than 40 years. We finally highlight that it is noteworthy to consider KFD as differential diagnosis of lymphadenopathy even in old patients, and, since a misdiagnosis of lymphoma is actually feasible, an early biopsy has to be taken into account for confirming diagnosis and helping in the timely and appropriate management.

Histopathology-guided management of ocular surface squamous neoplasia with corneal stromal or scleral invasion using ruthenium-106 plaque brachytherapy

2021 ◽  
pp. bjophthalmol-2021-319201
Author(s):  
Raksha Rao ◽  
Santosh G Honavar ◽  
Sumeet Lahane ◽  
Kaustubh Mulay ◽  
Vijayanand Palkonda Reddy
Keyword(s):  
Visual Acuity ◽  
Ocular Surface ◽  
Case Series ◽  
Prior Treatment ◽  
Tumour Regression ◽  
Excision Biopsy ◽  
Invasive Squamous Cell Carcinoma ◽  
Ocular Surface Squamous Neoplasia ◽  
Basal Diameter ◽  
Plaque Brachytherapy

Background/aimTo evaluate the safety and efficacy of ruthenium-106 (Ru-106) plaque brachytherapy in managing invasive ocular surface squamous neoplasia (OSSN).MethodsThis is a retrospective, non-comparative, interventional case series of 42 eyes with OSSN with histopathologically-proven corneal stromal and/or scleral invasion that underwent Ru-106 plaque brachytherapy. Main outcome measures were tumour regression, eye salvage, final visual acuity, treatment complications and metastasis.ResultsAt presentation, the mean tumour basal diameter was 9.3 mm (range 5–26 mm) and thickness 3.1 mm (range 1.5–11 mm). Prior treatment included excision biopsy in two patients (5%), incision biopsy and topical interferon in one each (2%). Following excision with 4 mm clinically clear margins, corneal stromal and/or scleral invasion of OSSN was confirmed in all 42 cases, with the excised base showing invasive squamous cell carcinoma. A total dose of 5000 cGy over a mean duration of 19.7 hours (range 7–41 hours) was provided to an axial depth of 2 mm using Ru-106 surface plaque. Over a mean follow-up of 36.9 months (range 22.3–72 months), complete tumour regression was achieved in all eyes (100%). Two eyes (5%) showed conjunctival tumour growth remote from the site of prior treatment. Visual acuity was maintained at ≥20/200 in 35 eyes (83%), with a loss of >2 Snellen lines in 1 eye (2%). There was no evidence of regional lymph node or systemic metastasis.ConclusionHistopathology-guided use of Ru-106 surface plaque brachytherapy is a safe and an effective adjuvant therapy in the management of corneal stromal and/or scleral invasion of OSSN.

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