scholarly journals Patterns of Dysgraphia in Primary Progressive Aphasia Compared to Post-Stroke Aphasia

2013 ◽  
Vol 26 (1-2) ◽  
pp. 21-34 ◽  
Author(s):  
Andreia V. Faria ◽  
Jenny Crinion ◽  
Kyrana Tsapkini ◽  
Melissa Newhart ◽  
Cameron Davis ◽  
...  
Keyword(s):  
Cognitive Processes ◽  
Imaging Techniques ◽  
Primary Progressive Aphasia ◽  
Neural Substrates ◽  
Focal Lesions ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Complex Process ◽  
Inferior Longitudinal Fasciculus ◽  
Word Forms

We report patterns of dysgraphia in participants with primary progressive aphasia that can be explained by assuming disruption of one or more cognitive processes or representations in the complex process of spelling. These patterns are compared to those described in participants with focal lesions (stroke). Using structural imaging techniques, we found that damage to the left extrasylvian regions, including the uncinate, inferior fronto-occipital fasciculus, and sagittal stratum (including geniculostriate pathway and inferior longitudinal fasciculus), as well as other deep white and grey matter structures, was significantly associated with impairments in access to orthographic word forms and semantics (with reliance on phonology-to-orthography to produce a plausible spelling in the spelling to dictation task). These results contribute not only to our understanding of the patterns of dysgraphia following acquired brain damage but also the neural substrates underlying spelling.

scholarly journals White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia

2017 ◽  
Vol 7 (1) ◽  
pp. 52-73 ◽  
Author(s):  
Karine Marcotte ◽  
Naida L. Graham ◽  
Kathleen C. Fraser ◽  
Jed A. Meltzer ◽  
David F. Tang-Wai ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Primary Progressive Aphasia ◽  
Healthy Controls ◽  
Radial Diffusivity ◽  
Connected Speech ◽  
Single Measure ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Inferior Longitudinal Fasciculus

Differential patterns of white matter disruption have recently been reported in the non-fluent (nfvPPA) and semantic (svPPA) variants of primary progressive aphasia (PPA). No single measure is sufficient to distinguish between the PPA variants, but connected speech allows for the quantification of multiple measures. The aim of the present study was to further investigate the white matter correlates associated with connected speech features in PPA. We examined the relationship between white matter metrics and connected speech deficits using an automated analysis of transcriptions of connected speech and diffusion tensor imaging in language-related tracts. Syntactic, lexical, and semantic features were automatically extracted from transcriptions of topic-directed interviews conducted with groups of individuals with nfvPPA or svPPA as well as with a group of healthy controls. A principal component analysis was performed in order to reduce the number of language measures and yielded a five-factor solution. The results indicated that nfvPPA patients differed from healthy controls on a syntactic factor, and svPPA patients differed from controls on two semantic factors. However, the patient groups did not differ on any factor. Moreover, a correlational analysis revealed that the lexical richness factor was significantly correlated with radial diffusivity in the left inferior longitudinal fasciculus, which suggests that semantic deficits in connected speech reflect a disruption of this ventral pathway, and which is largely consistent with the results of previous studies. Using an automated approach for the analysis of connected speech combined with probabilistic tractography, the present findings demonstrate that nfvPPA patients are impaired relative to healthy controls on syntactic measures and have increased radial diffusivity in the left superior longitudinal fasciculus, whereas the svPPA group was impaired on lexico-semantic measures relative to controls and showed increased radial diffusivity in the uncinate and inferior longitudinal fasciculus bilaterally.

scholarly journals A MEG study of the neural substrates of semantic processing in semantic variant primary progressive aphasia

Neurocase ◽  
2019 ◽  
Vol 25 (3-4) ◽  
pp. 118-129
Author(s):  
Jessica Pineault ◽  
Pierre Jolicœur ◽  
Stephan Grimault ◽  
Jacinthe Lacombe ◽  
Simona Maria Brambati ◽  
...  
Keyword(s):  
Semantic Processing ◽  
Primary Progressive Aphasia ◽  
Neural Substrates ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Semantic Variant

scholarly journals An area essential for linking word meanings to word forms: Evidence from primary progressive aphasia

2013 ◽  
Vol 127 (2) ◽  
pp. 167-176 ◽  
Author(s):  
D.S. Race ◽  
K. Tsapkini ◽  
J. Crinion ◽  
M. Newhart ◽  
C. Davis ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Word Meanings ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Word Forms

scholarly journals Taxonomic Interference Associated with Phonemic Paraphasias in Agrammatic Primary Progressive Aphasia

2019 ◽  
Vol 30 (4) ◽  
pp. 2529-2541
Author(s):  
M J Nelson ◽  
S Moeller ◽  
A Basu ◽  
L Christopher ◽  
E J Rogalski ◽  
...  
Keyword(s):  
Language Production ◽  
Search Task ◽  
Primary Progressive Aphasia ◽  
Metabolic Imaging ◽  
Output Stage ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Word Forms ◽  
Phonological Retrieval ◽  
And Control

Abstract Phonemic paraphasias are thought to reflect phonological (post-semantic) deficits in language production. Here we present evidence that phonemic paraphasias in non-semantic primary progressive aphasia (PPA) may be associated with taxonomic interference. Agrammatic and logopenic PPA patients and control participants performed a word-to-picture visual search task where they matched a stimulus noun to 1 of 16 object pictures as their eye movements were recorded. Participants were subsequently asked to name the same items. We measured taxonomic interference (ratio of time spent viewing related vs. unrelated foils) during the search task for each item. Target items that elicited a phonemic paraphasia during object naming elicited increased taxonomic interference during the search task in agrammatic but not logopenic PPA patients. These results could reflect either very subtle sub-clinical semantic distortions of word representations or partial degradation of specific phonological word forms in agrammatic PPA during both word-to-picture matching (input stage) and picture naming (output stage). The mechanism for phonemic paraphasias in logopenic patients seems to be different and to be operative at the pre-articulatory stage of phonological retrieval. Glucose metabolic imaging suggests that degeneration in the left posterior frontal lobe and left temporo-parietal junction, respectively, might underlie these different patterns of phonemic paraphasia.

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