scholarly journals Systemic Steroid Application Caused Sudden Death of a Patient with Sudden Deafness

2013 ◽  
Vol 2013 ◽  
pp. 1-2 ◽  
Author(s):  
Eriko Ogino-Nishimura ◽  
Takayuki Nakagawa ◽  
Ichiro Tateya ◽  
Harukazu Hiraumi ◽  
Juichi Ito
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Severe Hypertension ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Systemic Steroid ◽  
Systemic Corticosteroids ◽  
Threatening Condition ◽  
Life Threatening ◽  
The Right

A 63-year-old man, who was diagnosed with sudden sensorineural hearing loss (SSHL), showed severe hypertension 10 hours after prednisolone administration. Subsequently, the patient suddenly died due to pulmonary edema. The autopsy indicated a pheochromocytoma in the right adrenal gland, and the cause of death was determined to be a pheochromocytoma crisis induced by systemic administration of prednisolone. Pheochromocytoma crisis is a life-threatening condition and can result from the use of corticosteroids. Physicians should consider the risk of a pheochromocytoma crisis due to systemic corticosteroids in the treatment of patients with sudden sensorineural hearing loss.

Ethics of Placebo Control in Trials for Idiopathic Sudden Sensorineural Hearing Loss

2016 ◽  
Vol 155 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Miguel Maldonado Fernández ◽  
Susan Kornetsky ◽  
Laura Rubio Rodriguez
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Placebo Control ◽  
Cochrane Systematic Review ◽  
Sudden Loss ◽  
Randomized Controlled ◽  
Systemic Corticosteroids ◽  
Loss Of Hearing

Idiopathic sudden sensorineural hearing loss (ISSHL) involves sudden loss of hearing from cochlear or retrocochlear origin of unknown cause. Systemic corticosteroids may be considered in the management of ISSNHL. However, an updated Cochrane systematic review concludes that “the value of steroids in the treatment of idiopathic sudden sensorineural hearing loss remains unclear since the evidence obtained from randomized controlled trials is contradictory in outcome.” Therefore, a new clinical trial that addresses this question is mandatory. A first step in its design is to determine if placebo control would be ethically acceptable. We conclude that there is equipoise (uncertainty) about the use of corticosteroids for ISSHL. A new trial is justified—but with the inclusion of interim analyses to detect early imbalances on efficacy or safety and with the ability to stop the trial if needed.

Sudden sensorineural hearing loss: when is it idiopathic?

2010 ◽  
Vol 124 (6) ◽  
pp. 690-693 ◽  
Author(s):  
H Wilson ◽  
D J Alderson
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Preliminary Investigation ◽  
Liver Function Tests ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Relative Uncertainty ◽  
The Right

AbstractObjective: To highlight the importance of assessing the certainty of a diagnosis of idiopathic sudden sensorineural hearing loss, and of modifying patient management accordingly.Case report: A patient presented with sudden sensorineural hearing loss in the right ear. Following assessment and preliminary investigation, a diagnosis of idiopathic sudden sensorineural hearing loss was made. Steroid treatment was commenced. Two weeks later, the patient experienced sudden sensorineural hearing loss in the left ear, and scalp tenderness. Subsequent biopsy confirmed giant cell arteritis.Conclusions: Management of idiopathic sudden sensorineural hearing loss should be guided by the level of certainty of diagnosis. If there is relative uncertainty, risk factors for specific diagnoses should be sought, the patient should be followed more closely, and investigation should be tailored appropriately. Giant cell arteritis should be considered in patients older than 50 years, those exhibiting suggestive signs or symptoms, and those with elevated inflammatory markers or deranged liver function tests.

scholarly journals Combined Intratympanic and Systemic Steroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss

2021 ◽  
Vol 124 (1) ◽  
pp. 35-42
Author(s):  
Yoshihiko Hiraga ◽  
Koichiro Wasano ◽  
Taiji Kawasaki ◽  
Nobuyoshi Tsuzuki ◽  
Sosuke Sahara ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Systemic Steroid ◽  
Systemic Steroid Therapy

Atresia and Sudden Sensorineural Hearing Loss

2012 ◽  
Vol 23 (04) ◽  
pp. 241-248
Author(s):  
Steven P. Smith ◽  
Simon Milov ◽  
Joel A. Goebel
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Conductive Hearing Loss ◽  
Hearing Aid ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Bone Anchored Hearing Aid ◽  
The Right ◽  
Conductive Hearing

This case study summarizes findings in an adult male, aged 57, who presented to the Adult Audiology Clinic with aural atresia in the right ear resulting in a conductive hearing loss and a sudden sensorineural hearing loss in the left ear. Treatment options included reconstruction surgery in the right ear, bone anchored hearing aid in the right ear to overcome the conductive hearing loss, bone anchored hearing aid in the left ear for single sided deafness, and intratympanic steroid injections in the left ear to salvage hearing.This case study highlights that when a patient is educated on all available options the patient is then able to make a decision comfortable to him and to help improve his hearing.

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