scholarly journals A Case of the Large Cell Neuroendocrine Carcinoma of the Urinary Bladder

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Shinro Hata ◽  
Yoshihisa Tasaki
Keyword(s):  
Urinary Bladder ◽  
Tumor Cells ◽  
Neuroendocrine Carcinoma ◽  
Chromogranin A ◽  
Bladder Tumor ◽  
Immunohistochemical Study ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Review Of The Literature ◽  
Definite Treatment

Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Definite treatment strategy has not been established and prognosis of the disease is not clear yet. We report a case of primary LCNEC of the urinary bladder here with some review of the literature. The patient was a 84-year-old man. He underwent transurethral resection of bladder tumor (TURBT). Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive CD 56, synaptophysin, and chromogranin A (LCNEC). After TURBT, he has no sign of recurrence for 8 months. We have to strictly observe the progress because LCNEC is very aggressive.

scholarly journals Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature

2017 ◽  
Vol 6 (6) ◽  
pp. 881-885 ◽  
Author(s):  
Aya Kobayashi ◽  
Tamaki Yahata ◽  
Sakiko Nanjo ◽  
Mika Mizoguchi ◽  
Madoka Yamamoto ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Review Of The Literature ◽  
Uterine Corpus

Primary large cell neuroendocrine carcinoma of the urinary bladder

2006 ◽  
Vol 56 (11) ◽  
pp. 688-693 ◽  
Author(s):  
Kyung Hwa Lee ◽  
Soo Bang Ryu ◽  
Min Cheol Lee ◽  
Chang Soo Park ◽  
Sang Woo Juhng ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma

A Primary Large Cell Neuroendocrine Carcinoma of the Urinary Bladder in a 19-year-old Man

2008 ◽  
Vol 49 (7) ◽  
pp. 647
Author(s):  
Whi-An Kwon ◽  
Yun-Sok Ha ◽  
Ok-Jun Lee ◽  
Yong-June Kim ◽  
Seok-Joong Yun ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma

PS02.193: A CASE OF LARGE CELL NEUROENDOCRINE CARCINOMA OF THE ESOPHAGOGASTRIC JUNCTION

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 176-177
Author(s):  
Takuo Takehana ◽  
Kazuhiro Yamamoto ◽  
Shunsuke Kawai
Keyword(s):  
Gastrointestinal Tract ◽  
Tumor Cells ◽  
Neuroendocrine Carcinoma ◽  
Esophagogastric Junction ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Nuclear Bodies ◽  
Upper Gastrointestinal Tract ◽  
Positive Staining ◽  
Upper Gastrointestinal

Abstract Background The frequency of occurrence of neuroendocrine carcinoma (NEC) in the upper gastrointestinal tract is low, and especially large cell neuroendocrine carcinoma (LCNEC) is extremely rare disease. We report a case of LCNEC of the esophagogastric junction with relapse-free survival in 1 year and 3 months after surgical treatment. Methods An 81 - year—old Japanese man was referred to our hospital because of a semicircular ulcerative lesion in the esophagogastric junction (EGJ) by esophagogastroduodenoscopy of routine medical checkup. Biopsy from the lesion showed proliferation of tumor cells with clear nuclear bodies and irregular nuclei. Immunohistochemistry (IHC) demonstrated weakly positive staining of AE1/AE3, and CD3, CD20, S-100 and HMB 45 were negative. Computed tomography (CT) revealed a thickened wall of the EGJ and a lymphadenopathy of the cardiac node without any metastases to other organs. The patient was diagnosed with carcinoma in EJG, Stage III T3N1M0. We performed thoracoscopic esophagectomy with two-filed lymphadenectomy. Results Macroscopically, the ulcerative tumor measured 55 × 50mm invaded to the adventitia and was approximately centered in the EGJ. Histologically, the tumor cells showed large nuclei with highly frequent mitoses. IHC revealed that tumor was LCNEC positive for synaptophysin. One lymph node metastasis was found among 39 dissected lymph nodes. Finally, the pathological stage was T3N1M0, IIIA. On postoperative day 7, we performed the drainage for intra-abdominal abscess. He was discharged on postoperative day 44. Adjuvant chemotherapy was not performed, because the patient refused it. He was well and had no evidence of recurrence 15 months after surgery. Conclusion LCNECs of the esophagus or stomach are very rare but highly malignant tumors. It is expected that the number of reports of LCNEC in the upper gastrointestinal tract will increase. It is necessary to collect information on more cases to improve prognosis and to establish appropriate treatment guidelines. Disclosure All authors have declared no conflicts of interest.

scholarly journals Advanced Composite of Large Cell Neuroendocrine Carcinoma and Squamous Cell Carcinoma: A Case Report of Uterine Cervical Cancer in a Virgin Woman

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ryusuke Murakami ◽  
Iemasa Kou ◽  
Kenjiro Date ◽  
Hirofumi Nakayama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Neuron Specific Enolase ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Hpv Test

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is very rare and aggressive. The prognosis is very poor despite multimodal treatment. We report a virgin woman with FIGO stage 4b LCNEC of uterine cervix coexisting with squamous cell carcinoma. An early thirties virgin woman presented with 2-month history of abdominal pain. A chest X-ray showed multiple lung metastatic tumors. A vaginal smear showed malignant cells, and a biopsy specimen had features of LCNEC. The tumor showed trabecular patterns. Tumor cells possessed a moderate amount of cytoplasm, prominent nucleoli, and large nuclei. The tumor cells are stained positive for synaptophysin, chromogranin A, and neuron specific enolase (NSE). The invasive tumor cells in connection with cervical squamous epithelium were focally positive for 34bE12. We made a diagnosis of composite LCNEC and nonkeratinizing squamous cell carcinoma. High-risk HPV test was negative with hybridized captured method 2.

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