Protective Effect of Repeatedly Preadministered Brazilian Propolis Ethanol Extract against Stress-Induced Gastric Mucosal Lesions in Rats

The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single preadministration (50 mg/kg). The repeated BPEE preadministration attenuated WIRS-induced gastric mucosal lesions and gastric mucosal oxidative stress more largely than the single BPEE preadministration. In addition, the repeated BPEE preadministration attenuated neutrophil infiltration in the gastric mucosa of rats exposed to WIRS. The protective effect of the repeated preadministration of BPEE against WIRS-induced gastric mucosal lesions was similar to that of a single preadministration of vitamin E (250 mg/kg) in terms of the extent and manner of protection. From these findings, it is concluded that BPEE preadministered in a repeated manner protects against gastric mucosal lesions in rats exposed to WIRS more effectively than BPEE preadministered in a single manner possibly through its antioxidant and anti-inflammatory actions.

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Contribution of NO synthases to neutrophil infiltration in the gastric mucosal lesions in rats with water immersion restraint stress

FEBS Letters ◽

10.1016/s0014-5793(98)00237-3 ◽

1998 ◽

Vol 425 (2) ◽

pp. 243-248 ◽

Cited By ~ 46

Author(s):

Keiji Nishida ◽

Yoshiji Ohta ◽

Isao Ishiguro

Keyword(s):

Restraint Stress ◽

Water Immersion ◽

Neutrophil Infiltration ◽

Gastric Mucosal Lesions ◽

Water Immersion Restraint Stress ◽

Mucosal Lesions

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SPLENIC PROTECTIVE EFFECT OF WHITE TURMERIC EXTRACT AGAINST COPPER TOXICITY IN MALE WISTAR RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i5.40789 ◽

2021 ◽

pp. 66-69

Author(s):

LINDA CHIUMAN

Keyword(s):

Protective Effect ◽

Wistar Rats ◽

Copper Toxicity ◽

Ethanol Extract ◽

Neutrophil Infiltration ◽

Turmeric Extract ◽

Male Wistar Rats ◽

The Impact ◽

Positive Groups ◽

Preparation And Evaluation

Objective: This study was aimed to investigate the protective effect of white turmeric against copper splenic toxicity in male Wistar rats. Methods: This study used 30 rats divided into six groups: Negative groups, positive groups, Ethanol Extract of White Turmeric I-III. After 14 days, all rats were sacrificed by chloroform inhalation, and the spleen was excised and process to histopathology preparation and evaluation. Results: The result of this study showed that white turmeric acutely protected spleen from the impact of copper by reducing congestion/vasodilatation of the blood vessel (p=0.002), neutrophil infiltration (p<0.05), and lymphoid necrosis (p<0.05). Nevertheless, white turmeric extract may induce chronic inflammation by increasing the number of macrophage cells (p=0.003). Conclusion: Overall, it can be concluded that the white turmeric extracts acutely protect spleen from the impact of copper.

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