scholarly journals Reslip of a Previously Fixed Slipped Upper Femoral Epiphysis with an Associated Vitamin D Deficiency

2014 ◽  
Vol 2014 ◽  
pp. 1-2
Author(s):  
Aziz Ul Haque ◽  
Benjamin Bloch ◽  
Alwyn Abraham
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Growth Plate ◽  
Unique Case ◽  
Slipped Upper Femoral Epiphysis ◽  
Biomechanical Instability

Slipped upper femoral epiphysis (SUFE) is a relatively common adolescent hip disorder that represents a biomechanical instability of the proximal femoral growth plate. A link between vitamin D deficiency and SUFE has emerged in recent years; however, we present a unique case of a 10-year-old girl who presented with a reslip of a previously fixed SUFE with an associated vitamin D deficiency.

scholarly journals Vitamin D Deficiency in Slipped Upper Femoral Epiphysis

2016 ◽  
Vol 36 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Julia Judd ◽  
Rachel Welch ◽  
Anna Clarke ◽  
Isabel C. Reading ◽  
Nicholas M.P. Clarke
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Slipped Upper Femoral Epiphysis

scholarly journals Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

2008 ◽  
Vol 29 (6) ◽  
pp. 726-776 ◽  
Author(s):  
Roger Bouillon ◽  
Geert Carmeliet ◽  
Lieve Verlinden ◽  
Evelyne van Etten ◽  
Annemieke Verstuyf ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Growth Plate ◽  
Vitamin D Receptor ◽  
Endocrine System ◽  
Bone Homeostasis ◽  
High Calcium Intake ◽  
Full Spectrum ◽  
High Calcium ◽  
Deficient Mice

Abstract The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)2D], can now be better evaluated by critical analysis of mice with engineered deletion of the vitamin D receptor (VDR). Absence of a functional VDR or the key activating enzyme, 25-OHD-1α-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe vitamin D deficiency. The intestine is the key target for the VDR because high calcium intake, or selective VDR rescue in the intestine, restores a normal bone and growth plate phenotype. The VDR is nearly ubiquitously expressed, and almost all cells respond to 1,25-(OH)2D exposure; about 3% of the mouse or human genome is regulated, directly and/or indirectly, by the vitamin D endocrine system, suggesting a more widespread function. VDR-deficient mice, but not vitamin D- or 1α-hydroxylase-deficient mice, and man develop total alopecia, indicating that the function of the VDR and its ligand is not fully overlapping. The immune system of VDR- or vitamin D-deficient mice is grossly normal but shows increased sensitivity to autoimmune diseases such as inflammatory bowel disease or type 1 diabetes after exposure to predisposing factors. VDR-deficient mice do not have a spontaneous increase in cancer but are more prone to oncogene- or chemocarcinogen-induced tumors. They also develop high renin hypertension, cardiac hypertrophy, and increased thrombogenicity. Vitamin D deficiency in humans is associated with increased prevalence of diseases, as predicted by the VDR null phenotype. Prospective vitamin D supplementation studies with multiple noncalcemic endpoints are needed to define the benefits of an optimal vitamin D status.

scholarly journals Spatial periodicity in growth plate shear mechanical properties is disrupted by vitamin D deficiency

2013 ◽  
Vol 46 (10) ◽  
pp. 1597-1603 ◽  
Author(s):  
Derin Sevenler ◽  
Mark R. Buckley ◽  
Grace Kim ◽  
Marjolein C.H. van der Meulen ◽  
Itai Cohen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Growth Plate ◽  
Spatial Periodicity

scholarly journals Cardiac, bone and growth plate manifestations in hypocalcemic infants: revealing the hidden body of the vitamin D deficiency iceberg

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Suma Uday ◽  
Nadja Fratzl-Zelman ◽  
Paul Roschger ◽  
Klaus Klaushofer ◽  
Ashish Chikermane ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Growth Plate
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