Pseudo Vitamin D — Deficiency, Type I: A Quantitative X-Ray Microprobe Analysis of The Epiphyseal Growth Plate and Histochemistry of Various Intestinal Enzymes

1995 ◽  
pp. 533-534
Author(s):  
R. H. Barckhaus ◽  
F. Greinke ◽  
J. Harmeyer ◽  
R. Kaune ◽  
R. Gossrau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Growth Plate ◽  
Microprobe Analysis ◽  
Type I ◽  
Epiphyseal Growth Plate ◽  
Intestinal Enzymes ◽  
X Ray ◽  
Deficiency Type

scholarly journals Vitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab Adolescents

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1870 ◽  
Author(s):  
Mohammad Masoud ◽  
Majed Alokail ◽  
Sobhy Yakout ◽  
Malak Khattak ◽  
Marwan AlRehaili ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Iron ◽  
Iron Status ◽  
Group Analysis ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Post Intervention ◽  
King Saud University ◽  
Deficiency Type

Vitamin D deficiency has been shown to affect iron status via decreased calcitriol production, translating to decreased erythropoiesis. The present study aimed to determine for the first time whether vitamin D supplementation can affect iron levels among Arab adolescents. A total of 125 out of the initial 200 Saudi adolescents with vitamin D deficiency (serum 25(OH)D < 50 nmol/L) were selected from the Vitamin D-School Project of King Saud University in Riyadh, Saudi Arabia. Cluster randomization was done in schools, and students received either vitamin D tablets (1000 IU/day) (N = 53, mean age 14.1 ± 1.0 years) or vitamin D-fortified milk (40IU/200mL) (N = 72, mean age 14.8 ± 1.4 years). Both groups received nutritional counseling. Anthropometrics, glucose, lipids, iron indices, and 25(OH)D were measured at baseline and after six months. Within group analysis showed that post-intervention, serum 25(OH)D significantly increased by as much as 50%, and a parallel decrease of −42% (p-values <0.001 and 0.002, respectively) was observed in serum iron in the tablet group. These changes were not observed in the control group. Between-group analysis showed a clinically significant increase in serum 25(OH)D (p = 0.001) and decrease in iron (p < 0.001) in the tablet group. The present findings suggest a possible inhibitory role of vitamin D supplementation in the iron indices of healthy adolescents whose 25(OH)D levels are sub-optimal but not severely deficient, implying that the causal relationship between both micronutrients may be dependent on the severity of deficiency, type of iron disorder, and other vascular conditions that are known to affect hematologic indices. Well-designed, randomized trials are needed to confirm the present findings.

Studies of the Porcine Intestinal Calcitriol Receptor in Pseudo-Vitamin D Deficiency Rickets Type I

1990 ◽  
Vol 79 (4) ◽  
pp. 409-414 ◽  
Author(s):  
B. Schröder ◽  
R. Kaune ◽  
J. Harmeyer
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rate Constant ◽  
Clinical Symptoms ◽  
Binding Capacity ◽  
Relative Molecular Mass ◽  
Type I ◽  
Binding Properties ◽  
Deficiency Rickets ◽  
And Control

1. Calcitriol (1,25-dihydroxyvitamin D3) concentrations in plasma of humans and pigs with pseudo-vitamin D deficiency rickets type I (PVDRI) have been reported to be significantly lower than in normal subjects and animals. Sometimes, however, calcitriol concentrations are relatively high in these subjects and animals (50–80 pmol/l) and nevertheless clinical symptoms of rickets develop. We have studied whether or not the development of rachitic lesions in piglets with PVDRI is due to altered binding properties of the intestinal calcitriol receptor in addition to the defective renal production of calcitriol. PVDRI piglets with clinical and biochemical symptoms of rickets (hypocalcaemia, increased activity of alkaline phosphatase) and with calcitriol concentrations in plasma of 83.7 ± 4.2 pmol/l (n = 7) were used. They were compared with unaffected piglets with normal calcitriol concentrations (178.0 ± 17.7 pmol/l, n = 9). 2. The equilibrium dissociation constant (Kd) of the receptor in the PVDRI piglets (0.31 ± 0.05 nmol/l) and in control piglets (0.33 ± 0.05 nmol/l) and the maximum binding capacity (Bmax.) (674 ± 103 and 719 ± 122 fmol/mg of protein, respectively) were not different (n = 9). 3. The association rate constant (kass) at 4°C [0.15 × 107 and 0.24 × 107 (mol/l)−1 min−1] and the dissociation rate constant (kdiss) (0.40 × 10−3 and 0.48 × 10−3 min−1; half-life of dissociation = 24.1 and 28.9 h, respectively) were also not different between diseased and control piglets. 4. No differences between PVDRI and control piglets were also found for the relative molecular mass (47 500 and 47700, respectively) and the Stokes' radius (3.04 and 3.05 nm, respectively) of the calcitriol receptor. 5. It is concluded that the intestinal calcitriol receptor of this animal model functions normally and that changes in binding properties and concentration of the intestinal calcitriol receptor do not contribute to the development of rachitic lesions in PVDRI piglets.

Bone loss and vitamin D deficiency post gastrectomy for gastro-esophageal malignancy.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 165-165 ◽  
Author(s):  
Kiran Virik ◽  
Robert Wilson
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Disease ◽  
Bone Health ◽  
Nutritional Supplementation ◽  
Type I ◽  
Mineral Density ◽  
Post Surgery

165 Background: Metabolic bone disease is a known but incompletely understood consequence of gastrectomy. Post gastrectomy osteoporosis (OP) is multifactorial. Evidence suggests that patients who undergo this surgery require long term bone health assessment and nutritional support. Methods: 30 post gastrectomy patients (2000-2008) from a single centre in Australia were evaluated re bone health post surgery and post nutritional supplementation. Exploratory analysis included: age, gender, pathology, type of surgery, 25 OH-vitamin D, calcium, parathyroid hormone (PTH), bone mineral density (BMD), vertebral XRs, urinary calcium and N telopeptides of type I collagen. Other risk factors evaluated were: smoking, corticosteroid use, alcohol intake, hyperthyroidism, menopausal status, hyperparathyroidism (hPTH), pre-existing bone disease. Results: The median age of the cohort was 67.5 (range 53-83) of whom 22 (73%) were male. Histology showed 16 (53%) gastric adenocarcinoma, 6 (20%) esophageal adenocarcinoma, 2 (7%) GISTs, 5 (17%) gastric/duodenal lymphoma and 1 other category. Similar numbers of patients underwent total (12) and partial/distal gastrectomy (12), with 6 having a subtotal gastrectomy. 22 (73%) had a Roux-en-Y or BR II reconstruction and 8 had a BRI/other. Median time from surgery to first BMD was 54.5 months (range 12-360) with median correlative calcium level 2.24 (range 1.97-2.49), median vitamin D level 43 (range 11-82) and median PTH 6.4 (range 1.8-13.8). Osteoporosis was diagnosed in 14 (47%) of patients, osteopenia in 14 and 2 (7%) patients had a normal BMD. Low vitamin D was seen in 23 (77%) patients, low calcium levels in 5 (17%) and secondary hPTH in 12 (41%). Post nutritional supplementation preliminary results showed 2/23 (9%) had a low vitamin D level, 3/11 (27%) had secondary hPTH, 5/19 (26%) had osteoporosis, 12/19 (63%) had osteopenia and 2/19 had a normal BMD. Analysis of other risk factors is to follow. Conclusions: Poor bone health and vitamin D deficiency is a clinically significant problem post gastrectomy. Patients should undergo long term nutritional and bone health surveillance in addition to their oncological follow up post resection.

scholarly journals Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

2018 ◽  
Vol 7 (2) ◽  
pp. 55-60
Author(s):  
Nozar Dorestan ◽  
Sara Bahadoram ◽  
Mohammad Bahadoram ◽  
Mohammadreza Khosravi ◽  
Mohammad Davoodi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Heart Diseases ◽  
Daily Intake ◽  
Type I ◽  
Bowel Diseases ◽  
Progression Of Kidney Disease ◽  
Vitamin D Supplements ◽  
The Relationship

Vitamin D or cholecalciferol, as a steroidal hormone, regulates the calcium homeostasis, and bone formation with reabsorption through kidneys, parathyroid glands and bowel. There are at least 800 human genes connected with vitamin D. Previous research has confirmed the relationship between vitamin D and colorectal cancers, infections, heart diseases, multiple sclerosis (MS), bone disorders, inflammatory and autoimmune diseases, inflammatory bowel diseases, diabetes mellitus type-I and II and also progression of kidney disease. However, the relationship of vitamin D deficiency and developing of breast cancer, rheumatoid arthritis and osteoporosis is unknown. In fact, the effect of vitamin D deficiency on pathogenesis of different diseases is controversial. To cope with vitamin D deficiency, there are different recommendations such as daily intake of vitamin D supplements and more exposure to sunlight.

scholarly journals Laboratory Parameters of Bone Metabolism in Premature Infants and Children Born Using In Vitro Fertilization

2021 ◽  
Vol 20 (6) ◽  
pp. 103-110
Author(s):  
Natalya A. Natalya A. Druzhinina ◽  
Dinara R. Merzlyakova ◽  
Gulnaz A. Vakhitova ◽  
Zilia А. Shangareeva ◽  
Aliya R. Khabibullina ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Bone Metabolism ◽  
Vitamin D Deficiency ◽  
Premature Infants ◽  
Type I Collagen ◽  
Plasma Vitamin ◽  
Type I ◽  
Premature Babies ◽  
Low Weight

Aim. To study the indicators of bone metabolism in premature babies born naturally and children born with IVF. Material and methods. The premature babies’ study was conducted, they were divided into 4 groups: depending on the method of birth and weight: 1st-children born with IVF, with very low weight; the second group – similar to the first, but children with extremely low weight; the third – children with very low weight, born naturally, with ; the fourth – similar to the 3rd, but with extremely low weight. The level of calcium, parathyroid hormone, calcitonin and C-terminal telopeptides of type I collagen was determined. Results and discussion. Diagnosis of vitamin D deficiency is possible only by measuring certain biochemical parameters, primarily the levels of its metabolites in the blood. Clinical symptoms of vitamin D deficiency in the form of rickets, osteomalacia, osteoporosis and extra-skeletal manifestations as a result of this vitamin deficiency occur over a long period of time. The most informative indicator of the body’s vitamin D supply is the content of calcidiol [25 (OH)D] in both serum and blood plasma. Vitamin D deficiency was detected in more than half (67.7±4.8%) of premature newborns in the first year of life. It seemed that in premature babies born in different ways, vitamin D deficiency was noted in 8 %, insufficiency – in 67.7 %, and the normal content in 27.5 %. In children at an early age, there is a violation of bone metabolism (an increase in the level of calcium, parathyroid hormone, calcitonin, on the one hand, and a decrease in the C-terminal telopeptides of type I collagen, on the other). These changes were associated with the weight of children, while aggressive disorders were noted in children with extremely low weight. In premature infants (with a body weight of less than 1500 g), monitoring of the level of vitamin D in the blood and C-terminal telopeptides of type 1 collagen should be recommended. Conclusion. Bone modeling has a great advantage due to the analysis of the blood serum biomarkers levels in premature infants, it enables to establish the features of osteogenesis.

Microanalysis in mitochondrial granules of bone cells incident to experimental tooth movement

1978 ◽  
Vol 36 (2) ◽  
pp. 664-665
Author(s):  
A. Hirashita ◽  
Y. Nakamura ◽  
E. Okumura ◽  
Y. Kuwabara
Keyword(s):  
Growth Plate ◽  
Tooth Movement ◽  
Bone Cells ◽  
Epiphyseal Growth Plate ◽  
Control Groups ◽  
Adult Rats ◽  
X Ray ◽  
Bone Calcification ◽  
Experimental Tooth Movement

Biological functions of Ca in mitochondrial granules have been reported by a number of investigators. It is said that mitochondrial granules of chondrocytes, osteoblasts and osteocytes in rat epiphyseal growth plate with regard to bone calcification and these granules of osteoclasts at bone-resorbing site play an important role of Ca-transport. However, these results were reported about the first stage of calcification in rat epiphyseal growth plate, so that the changes of bone tissues in adult rats seem to be not always the same.The purpose of this work is, by electron probe X-ray microanalysis method, to do the elemental analysis in mitochondrial granules of osteoblasts, osteocytes and osteoclasts incident to experimental tooth movement in adult rats, and to compare them with these analysis in control groups.

Relationship between Body Mass Index - BMI and Vitamin D Concentrations in Women with Postmenopausal Osteoporosis

2021 ◽  
Vol 17 ◽  
Author(s):  
Joanna Głogowska-Szeląg ◽  
Aleksandra Bełz ◽  
Dariusz Kajdaniuk ◽  
Beata Kos–Kudła ◽  
Bogdan Marek ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Osteoporosis ◽  
Body Mass ◽  
Hypovitaminosis D ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
X Ray ◽  
Metabolic Bone

Introduction: Osteoporosis is the most common metabolic bone disease. Vitamin D deficiency, often associated with osteoporosis and other bone tissue disorders, is spread worldwide. Among other factors, obesity seems to be a major cause of the growing hypovitaminosis D. Aim: The aim of the study was to assess the correlation between body mass index (BMI) and vitamin D concentrations in postmenopausal women diagnosed with osteoporosis. Materials and methods: Sixty nine women with postmenopausal osteoporosis were included in study. Dual- energy X-ray absorptiometry and vitamin D measures were performed in all patients. Three groups, BMI- dependent, were distinguished: normal weight, overweight and obesity group. Results: The vitamin D deficiency was found in all women with postmenopausal osteoporosis. There was no correlation between BMI and vitamin D level. Conclusions: Vitamin D deficiency is frequent in population of patients diagnosed with postmenopausal osteoporosis, regardless of their BMI.

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