scholarly journals Necrotizing Soft Tissue Infection Occurring after Exposure toMycobacterium marinum

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Shivani S. Patel ◽  
M. Lance Tavana ◽  
M. Sean Boger ◽  
Soe Soe Win ◽  
Bassam H. Rimawi
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Skin Barrier ◽  
Tissue Infection ◽  
Soft Tissue Infections ◽  
Upper Limbs ◽  
Necrotizing Soft Tissue Infection ◽  
Cutaneous Infections ◽  
Fish Exposure ◽  
Necrotizing Soft Tissue Infections

Cutaneous infections caused byMycobacterium marinumhave been attributed to aquarium or fish exposure after a break in the skin barrier. In most instances, the upper limbs and fingers account for a majority of the infection sites. While previous cases of necrotizing soft tissue infections related toM. marinumhave been documented, the importance of our presenting case is to illustrate the aggressive nature ofM. marinumresulting in a persistent necrotizing soft tissue infection of a finger that required multiple aggressive wound debridements, followed by an amputation of the affected extremity, in order to hasten recovery.

scholarly journals Necrotizing Soft-Tissue Infections: Current Concepts and Challenges

2016 ◽  
Vol 6 (1) ◽  
pp. 1-2
Author(s):  
Avgoustou C ◽  
Avgoustou Ch
Keyword(s):  
Soft Tissue ◽  
Infectious Diseases ◽  
Necrotizing Fasciitis ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infection ◽  
Yearly Incidence ◽  
Necrotizing Soft Tissue Infections

Necrotizing Soft-Tissue Infection (NSTI) and the most fulminant form of it, Necrotizing Fasciitis (NF), are rather uncommon but severe and destructive infectious diseases with high rates of mortality. Yearly incidence is reported to be 0.4 cases per 100,000 habitats, while reported mortality ranges from 21% to 43% [1].

Soft Tissue Infection

2019 ◽  
Author(s):  
Mark A. Malangoni ◽  
Christopher R McHenry
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Toxic Shock Syndrome ◽  
Bacterial Infections ◽  
Subcutaneous Tissue ◽  
Tissue Infection ◽  
Soft Tissue Infections ◽  
Toxic Shock ◽  
Necrotizing Soft Tissue Infection ◽  
Human Bites

Soft tissue infections are a diverse group of diseases that involve the skin and underlying subcutaneous tissue, fascia, or muscle. The authors review the diagnosis and management of the main soft tissue infections seen by surgeons, including both superficial infections and necrotizing infections. When the characteristic clinical features of necrotizing soft tissue infection are absent, diagnosis may be difficult. In this setting, laboratory and imaging studies become important. Studies emphasizes that computed tomography should continue to be used judiciously as an adjunct to clinical judgment. The delay between hospital admission and initial débridement is the most critical factor influencing morbidity and mortality. Once the diagnosis of necrotizing soft tissue infection is established, patient survival and soft tissue preservation are best achieved by means of prompt operation. Bacterial infections of the dermis and epidermis are covered in depth, along with animal and human bites. Methicillin-resistant Staphylococcus aureus (MRSA) accounts for up to 70% of all S. aureus infections acquired in the community and is the most common organism identified in patients presenting to the emergency department with a skin or soft tissue infection. The more classic findings associated with deep necrotizing infections—skin discoloration, the formation of bullae, and intense erythema—occur much later in the process. It is important to understand this point so that an early diagnosis can be made and appropriate treatment promptly instituted. The review’s discussion covers in depth the etiology and classification of soft tissue infection, pathogenesis of soft tissue infections, toxic shock syndrome, and reports on mortality from necrotizing soft tissue infection. This review 8 figures, 22 tables, and 58 references. Keywords: Erysipelas, cellulitis, soft tissue infection, necrotizing fasciitis, myonecrosis, toxic shock syndrome

667 Necrotizing Soft Tissue Infection Within 48 Hours Post-Scald Burn: A Rare Presentation

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S190-S190
Author(s):  
Luis E Meza ◽  
Sarah Rehou ◽  
Courtney H Grotski ◽  
Shahriar Shahrohki
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Burn Injury ◽  
Clinical Signs ◽  
Tissue Infection ◽  
Burn Patients ◽  
Soft Tissue Infections ◽  
Rare Presentation ◽  
Comfort Care ◽  
Necrotizing Soft Tissue Infection

Abstract Introduction We report a case of a patient with a burn injury who developed a devastating necrotizing soft tissue infection (NSTI) early in the post-burn period. Methods An elderly male was admitted to an ABA verified burn centre after sustaining a 20% scald burn to his back and right upper extremity. He was found in the bathtub; a fall was suspected based on his history of Parkinson’s disease and a finding of bruising to his bilateral knees. Initially, his hospital course was uneventful apart from an elevated creatine kinase, which decreased with adequate resuscitation without signs or symptoms of compartment syndrome. Thirty-six hours following his admission, he developed rapid onset of progressively worsening renal function, respiratory requiring intubation, mechanical ventilation, and circulatory failure requiring vasopressor support. After ruling out other causes of shock and upon re-examination of his burns there were clinical signs of a rapidly advancing necrotizing soft tissue infection. He was taken urgently to the operating room for aggressive debridement of nonviable tissue. He underwent a right shoulder disarticulation and extensive debridement of the right chest, abdomen, and back. Intra-operative tissue samples and preoperative blood cultures were positive for Group A Streptococcus. The patient was predicted to require multiple operations and a prolonged hospital stay. Despite these interventions, his prognosis was poor. The family and the treatment team, in the context of the patient’s previous independent functioning, revised his goals of care on his first post-operative day. Life-sustaining treatment was withdrawn, and comfort care measures were implemented. The patient passed away two days later. Results We report a case of a patient with a burn injury who developed a devastating NSTI early in the post-burn period within 36–48 hours of presentation to a burn center. Soft-tissue infections in the immediate post-burn period are rare unless there is subsequent contamination. Burned tissue contains a large amount of necrotic tissue and protein-rich wound exudate, which provides a rich growth medium for bacteria. This, in addition to the immunosuppression secondary to the burn insult, favors the development of infection. NSTI in the context of thermal injury is a rare phenomenon and in the few reported cases in burn patients, necrotizing infections occurred closer to two weeks following the initial injury. Conclusions Necrotizing soft tissue infections are entities with a rapid and devastating course. The diagnosis is challenging, and occlusive dressings may contribute to a delay in diagnosis in burns. Acute hemodynamic compromise without any obvious cause should raise the suspicion for a necrotizing soft tissue infection and lead to early exposure of wounds in burn patients.

scholarly journals Study of the effectiveness of laboratory risk indicator for necrotizing fasciitis scoring system in the diagnosis of necrotizing fasciitis among patients presenting with soft tissue infections

2021 ◽  
Vol 8 (7) ◽  
pp. 2041
Author(s):  
Shreeniketan Nayak ◽  
Prakash S. Kattimani
Keyword(s):  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Soft Tissue Infection ◽  
Scoring System ◽  
Tissue Infection ◽  
Risk Indicator ◽  
Soft Tissue Infections ◽  
Predictive Values ◽  
Necrotizing Soft Tissue Infection ◽  
Lrinec Score

Background: Necrotizing soft tissue infection (NSTI) is an uncommon but life threatening disease with a high mortality rate. Delay in diagnoses and in surgery for debridement is associated with increased mortality rates. Hence here we would like to use this scoring system - laboratory risk indicator for necrotizing fasciitis (LRINEC) in patients presenting to our hospital with necrotizing soft tissue infection and if found to have good predictive values, it would be a boon to developing countries like India where the mortality of the disease is high (7% to 76%).Methods: Patients presenting with symptoms suggestive of soft tissue infection underwent clinical examination and basic laboratory investigations. Following which, information collected using semi structured proforma cum observational checklist. LRINEC scoring system applied to each of the study subjects at admission. The confirmatory diagnosis of necrotizing fasciitis done on patients who undergo surgery vide histopathology, irrespective of the result of the LRINEC scoring system. Tissue cultures and sensitivity patterns analyzed.Results: A total of 100 patients were enrolled. LRINEC score has an ability to diagnose necrotizing fasciitis from other soft tissue infections. High LRINEC score had more incidences of features of sepsis. Presence of the co morbidities tended to increase the LRINEC score. And defines patients with a high LRINEC score of >8 had higher mortality rate.Conclusions: LRINEC score is a simple clinical tool for the diagnosis of necrotizing fasciitis from other soft tissue infections. LRINEC scoring system and clinical assessment should be used concurrently for diagnosing necrotizing fasciitis from other soft tissue infections.

Group G Streptococcal Necrotizing Soft Tissue Infection

2016 ◽  
Vol 78 (6) ◽  
pp. 644-649
Author(s):  
Eriko MAEHARA ◽  
Gaku TSUJI ◽  
Yukihiro MIZOTE ◽  
Naohide TAKEUCHI ◽  
Masutaka FURUE
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

Can Paronychia Cause a Remote Necrotizing Soft Tissue Infection?

2011 ◽  
Vol 40 (1) ◽  
pp. e11-e13 ◽  
Author(s):  
Julian E. Losanoff ◽  
Anne E. Missavage ◽  
Paul Linneman ◽  
Boyd E. Terry
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

scholarly journals Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

2021 ◽  
pp. jim-2021-001837
Author(s):  
Morten Hedetoft ◽  
Peter Østrup Jensen ◽  
Claus Moser ◽  
Julie Vinkel ◽  
Ole Hyldegaard
Keyword(s):  
Oxidative Stress ◽  
Septic Shock ◽  
Soft Tissue ◽  
Hyperbaric Oxygen ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Heme Oxygenase 1 ◽  
Necrotizing Soft Tissue Infection ◽  
Before And After ◽  
Nitrite Nitrate

Necrotizing soft-tissue infection (NSTI) is a rare, severe, and fast-progressing bacterial infection associated with a high risk of developing sepsis or septic shock. Increasing evidence indicates that oxidative stress is crucial in the development and progression of sepsis, but its role in NSTI specifically has not been investigated. Some patients with NSTI receive hyperbaric oxygen (HBO2) treatment as the restoration of oxidative stress balance is considered an important mechanism of action, which HBO2 facilitates. However, a gap in knowledge exists regarding the effect of HBO2 treatment on oxidative stress in patients with NSTI. In the present observational study, we aimed to investigate HBO2 treatment effects on known markers of oxidative stress in patients with NSTI. We measured plasma myeloperoxidase (MPO), superoxide dismutase (SOD), heme oxygenase-1 (HO-1) and nitrite+nitrate in 80 patients with NSTI immediately before and after their first HBO2 treatment, and on the following day. We found that HBO2 treatment was associated with a significant increase in MPO and SOD by a median of 3.4 and 8.8 ng/mL, respectively. Moreover, we observed an HBO2 treatment-associated increase in HO-1 in patients presenting with septic shock (n=39) by a median of 301.3 pg/mL. All markers were significantly higher in patients presenting with septic shock compared to patients without shock, and all markers correlated with disease severity. High baseline SOD was associated with 90-day mortality. In conclusion, HBO2 treatment was associated with an increase in MPO and SOD in patients with NSTI, and oxidative stress was more pronounced in patients with septic shock.

scholarly journals A case of Apophysomyces trapeziformis necrotizing soft tissue infection

2013 ◽  
Vol 17 (12) ◽  
pp. e1240-e1242 ◽  
Author(s):  
Jose F. Echaiz ◽  
Carey-Ann D. Burnham ◽  
Thomas C. Bailey
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection
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